公开(公告)号：US20230172915A1

公开(公告)日：2023-06-08

申请号：US17923825

申请日：2021-05-07

申请人： PTC THERAPEUTICS, INC.

发明人： Nikolai A. NARYSHKIN ,  Jason GRACI ,  John BAIRD ,  Joseph COLACINO ,  Marla L. WEETALL ,  Liangxian CAO

IPC分类号： A61K31/437 ,  A61K31/675 ,  A61P31/14

CPC分类号： A61K31/437 ,  A61K31/675 ,  A61P31/14

摘要： One aspect described herein includes a method for treating coronavirus 2019 disease (COVID-19) caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) by administering an effective amount of a DHODH inhibitor. Another aspect described herein includes a method of treating COVD-19 by administering 4-chlorophenyl (S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate (PTC299), or a pharmaceutically acceptable salt thereof.