公开(公告)号：US09638687B2

公开(公告)日：2017-05-02

申请号：US14012885

申请日：2013-08-28

Applicant: Puget Sound Blood Center

Inventor： James Charles Zimring

IPC: G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/80

CPC classification number: G01N33/80 ,  G01N33/5005 ,  G01N33/53 ,  G01N2800/7066

Abstract: Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided.

公开(公告)号：US20160169866A1

公开(公告)日：2016-06-16

申请号：US14906242

申请日：2014-07-21

Applicant: PUGET SOUND BLOOD CENTER

Inventor： James Charles Zimring ,  Sherrill J. Slichter

IPC: G01N33/49 ,  G01N33/53 ,  G01N33/80 ,  C40B30/02

CPC classification number: G01N33/492 ,  G01N33/5308 ,  G01N33/80 ,  G01N2800/7066 ,  G16B35/00 ,  G16C20/60

Abstract: Compositions and methods determines post-transfusion survival of platelets and the suitability of platelet units for transfusion by measuring the levels of one or more markers in a platelet sample. A method determines post-transfusion survival of platelets (PL T) prior to transfusion, the method comprising the steps of: a) measuring the levels of one or more markers in a PL T sample selected from the group consisting of adenine, 13-HODE/9-HODE, Caprylate, Laurate, C-glycosyltryptophan, andro steroid monsulfate 2, and Unelucidated Compounds (UC) 1-4; b) comparing the level of the one or more markers in the PLT sample with the level of the one or more markers present in a control sample, wherein a higher or lower level of the one or more markers in the PL T sample is indicative of post-transfusion survival of platelets.

Abstract translation: 组合物和方法通过测量血小板样品中一种或多种标记物的水平来确定血小板的输血后存活和血小板单位适用于输血。 一种方法确定在输血前血小板（PL T）的输血后存活，所述方法包括以下步骤：a）测量PLT样品中一种或多种标记物的水平，所述PLT样品选自腺嘌呤，13-HODE / 9-HODE，辛酸盐，月桂酸盐，C-糖基色氨酸，类固醇甾类单硫酸盐2和未化合化合物（UC）1-4; b）将PLT样品中的一种或多种标记物的水平与对照样品中存在的一种或多种标志物的水平进行比较，其中PL T样品中的一种或多种标记物的较高或较低水平表示 输血后血小板存活。

公开(公告)号：US20140178904A1

公开(公告)日：2014-06-26

申请号：US14012885

申请日：2013-08-28

Applicant: Puget Sound Blood Center

Inventor： James Charles Zimring

IPC: G01N33/50

CPC classification number: G01N33/80 ,  G01N33/5005 ,  G01N33/53 ,  G01N2800/7066

Abstract: Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided.

Abstract translation: 提供了通过测量红细胞样品中一种或多种标记物的水平来确定红血球的输血后存活或毒性的红血球单元用于输血的组合物和方法。