公开(公告)号：US5101017A

公开(公告)日：1992-03-31

申请号：US34869

申请日：1987-04-06

申请人： Pablo Rubinstein ,  Margaret Nichols

发明人： Pablo Rubinstein ,  Margaret Nichols

IPC分类号： C07K16/34 ,  C07K16/42

CPC分类号： C07K16/425 ,  C07K16/34 ,  Y10S530/808 ,  Y10S530/809

摘要： A monoclonal antibody which identifies the human blood group Duffy (ab) is provided. Such monoclonal antibody blocks the penetration of P. vivax malaria parasite into human red blood cells by virtue of effective blocking of the target molecule of the P. vivax malaria parasite. Such monoclonal antibody has a combining site having the same stereochemistry as the ligand site on P. vivax, and elicits anti-idiotypic antibodies that react with the parasite.

摘要翻译： 提供了鉴定人血型Duffy（ab）的单克隆抗体。 这种单克隆抗体通过有效阻断间日疟原虫疟疾寄生虫的靶分子，阻断间日疟原虫寄生虫渗入人红细胞。 这样的单克隆抗体具有与间日疟原虫配体位点相同的立体化学结合位点，引发与寄生虫反应的抗独特型抗体。