公开(公告)号：US4541488A

公开(公告)日：1985-09-17

申请号：US552135

申请日：1983-10-14

申请人： Pal Gomory ,  Janos Hegedus ,  Ferenc Kiss ,  Attila Simon

发明人： Pal Gomory ,  Janos Hegedus ,  Ferenc Kiss ,  Attila Simon

IPC分类号： E03B3/15 ,  B01D29/62 ,  C09K8/528 ,  E03B3/32 ,  E21B21/00 ,  E21B43/27

CPC分类号： B01D29/62 ,  C09K8/528

摘要： Process for increasing the water discharge of water delivering drilled wells, which can be characterized in that into the filter section of the well weak acids with a dissociation constant being less than K.sub.d =10.sup.-3 are introduced. After a dwelling period of longer duration, expediently 10 to 48 hours, as well as compressing, flushing is performed by means of a scavenging pump. Thereafter the solution of sodium bicarbonate and/or sodium hypochlorite is introduced into the filter section. After a longer dwelling period, expediently one to thirty-six hours, flushing is performed by means of the scavenging pump. As weak acids with a dissociation constant being less than K.sub.d =10.sup.-3 acetic acid, tartaric acid, citric acid, metaboric and/or tetraboric acid is used.

摘要翻译： PCT No.PCT / HU81 / 00049 Sec。 371日期：1983年10月14日 102（e）日期1983年10月14日PCT提交1981年12月26日PCT公布。 公开号WO83 / 02296 日期：1983年7月7日。增加输水钻井的排水量的过程，其特征在于引入解离常数小于Kd = 10-3的弱酸的过滤段。 在长时间的住宅期间，方便地10至48小时，以及压缩，通过清扫泵进行冲洗。 此后，将碳酸氢钠和/或次氯酸钠溶液引入过滤器部分。 经过较长的停留时间后，方便地一到三十六小时，通过扫气泵进行冲洗。 由于解离常数小于Kd = 10-3乙酸的弱酸，使用酒石酸，柠檬酸，偏硼酸和/或四硼酸。

公开(公告)号：US06884895B2

公开(公告)日：2005-04-26

申请号：US10409488

申请日：2003-04-08

申请人： Csaba Gönczi ,  Éva Csikós ,  István Hermecz ,  Gergely Héja ,  Árpád Illár ,  Lajos Nagy ,  Andrea Sántáné Csutor ,  Attila Simon ,  Kálmán Simon ,  Ágota Smelkóné Esek ,  Tiborné Szomor ,  Györgyné Szvoboda

发明人： Csaba Gönczi ,  Éva Csikós ,  István Hermecz ,  Gergely Héja ,  Árpád Illár ,  Lajos Nagy ,  Andrea Sántáné Csutor ,  Attila Simon ,  Kálmán Simon ,  Ágota Smelkóné Esek ,  Tiborné Szomor ,  Györgyné Szvoboda

IPC分类号： C07B61/00 ,  C07D209/34 ,  C07D209/96 ,  C07D405/04 ,  C07D209/54

CPC分类号： C07D405/04 ,  C07D209/34 ,  C07D209/96 ,  Y02P20/55

摘要： The invention relates to a process for the preparation of spiro[(4-cyclohexanone)-[3H]indol]-2′[1′H]-one derivatives of the general formula I wherein R1 and R2 independently stand for hydrogen, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4polyfluoroalkyl, C1-4polyfluoroalkoxy, C3-7cycloalkyloxy, C3-7cycloalkylthio, phenoxy, benzyloxy or nitro group—, characterized by reacting an indolin-2-one derivative of the general formula II wherein R1 and R2 are as defined above—with a compound capable for introducing a protective group, selected from 2-tetrahydropyranyl, 1-diethoxy-methylene or C1-4alkoxycarbonylethyl group, coupling the compound of general formula III, thus obtained—wherein R1 and R2 are as defined above and A stands for a protective group, selected from 2-tetrahydropyranyl, 1-diethoxy-methylene or C1-4alkoxycarbonylethyl group—with an acrylic acid C1-4ester, cyclizing the resulting compound of the general formula IV wherein R1, R2 and A are as defined above, R3 stands for C1-4 alkyl group—, eliminating the —COOR3 group and the A protective group of the keto-ester of general formula V wherein R1, R2, R3 and A are as defined above, optionally without isolation of the compounds of the general formulae IV

摘要翻译： 本发明涉及制备通式I的螺[（4-环己酮） - [3 H]吲哚] -2'[1'H] - 酮衍生物的方法，其中R 1和 R 2独立地代表氢，C 1-4烷基，C 1-4 - 烷氧基，C 1-4 - 烷基 >烷硫基，C 1-4 - 多氟烷基，C 1-4 - 多氟烷氧基，C 3-7环烷氧基，C 3-7 - 其中R 1和R 2各自独立地表示：其中R 1，R 2和R 2各自为 与可以引入选自2-四氢吡喃基，1-二乙氧基 - 亚甲基或C 1-4烷氧基羰基乙基的保护基的化合物，将由此得到的通式III的化合物 - 其中R 1和R 2如上定义，A代表保护基团，其选自2-四氢吡喃基，1-二乙氧基 - 亚甲基或C 1〜 4烷氧基羰基 与丙烯酸C 1-4 - 酯反应，将得到的通式Ⅳ化合物环化，其中R 1，R 2和R 2， A如上所定义，R 3代表C 1-4烷基，除去-COOR 3 O 3基团和A保护基团 的通式V的酮酯，其中R 1，R 2，R 3和A如上所定义，任选地不分离 通式IV的化合物

公开(公告)号：US06573386B1

公开(公告)日：2003-06-03

申请号：US10030648

申请日：2002-04-17

申请人： Csaba Gönczi ,  Éva Csikós ,  István Hermecz ,  Gergely Héja ,  Árpád Illár ,  Lajos Nagy ,  Andrea Sántáné Csutor ,  Attila Simon ,  Kálmán Simon ,  Ágota Smelkóné Esek ,  Tiborné Szomor ,  Györgyné Szvoboda

发明人： Csaba Gönczi ,  Éva Csikós ,  István Hermecz ,  Gergely Héja ,  Árpád Illár ,  Lajos Nagy ,  Andrea Sántáné Csutor ,  Attila Simon ,  Kálmán Simon ,  Ágota Smelkóné Esek ,  Tiborné Szomor ,  Györgyné Szvoboda

IPC分类号： C07D20954

CPC分类号： C07D405/04 ,  C07D209/34 ,  C07D209/96 ,  Y02P20/55

摘要： The invention relates to a process for the preparation of spiro [(4-cyclohexanone)-[3H]indol]-2′[1′H]-one derivatives of general formula I—wherein R1 and R2 independently stand for hydrogen, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4polyfluoroalkyl, C1-4polyfluoroalkoxy, C3-7cycloalkyloxy, C3-7cycloalkylthio, phenoxy, benzyloxy or nitro group—, characterized by reacting an indolin-2-one derivative of general formula II—wherein R1 and R2 are as defined above—with a compound capable for introducing a protective group, coupling the compound of general formula III, thus obtained—wherein R1 and R2 are as defined above and A stands for a protective group—with acrylic acid C1-4ester; cyclizing the resulting compound of general formula IV—wherein R1 and R2 are as defined above—with a compound capable for introducing a protective group, coupling the compound of formula III thus obtained,—wherein R1 and R2 are as defined above and A stands for a protective group—with an acrylic acid C1-4ester, cyclizing the resulting compound of formula IV—wherein R1 and R2 are as defined above R3 stands for C1-4alkyl and A stands for a protective group—, eliminating the—COOR3 group and the A protective group of the keto-ester of general formula V—wherein R1 and R2 are as defined above, R3 stands for C1-4alkyl and A stands for a protective group—, optionally without isolation of the compounds of general formulae IV and/or V and/or VI.

摘要翻译： 本发明涉及制备通式I的螺[（4-环己酮） - [3 H]吲哚] -2'[1'H] - 酮衍生物的方法，其中R 1和R 2独立代表氢，C1- 4-烷基，C 1-4烷氧基，C 1-4烷硫基，C 1-4多氟烷基，C 1-4多氟烷氧基，C 3-7环烷氧基，C 3-7环烷硫基，苯氧基，苄氧基或硝基，其特征在于使通式II的二氢吲哚-2-酮衍生物 - R1和R2如上定义 - 与能够引入保护基团的化合物偶合，由此得到的通式III化合物 - 其中R 1和R 2如上所定义，A代表保护基 - 与丙烯酸C1- 4ester; 使所得到的通式IV化合物（其中R 1和R 2如上定义）与可引入保护基的化合物环化，将所得式III化合物偶联，其中R 1和R 2如上所定义，A代表 保护基 - 与丙烯酸C1-4酯，使所得到的式IV化合物环化，其中R 1和R 2如上所定义。R3代表C 1-4烷基，A代表保护基，除去-COOR 3基团和 通式V的酮酯的保护基 - 其中R 1和R 2如上所定义，R 3表示C 1-4烷基，A代表保护基 - 任选地不分离通式IV和/或 V和/或VI。