公开(公告)号：US06762029B2

公开(公告)日：2004-07-13

申请号：US09745842

申请日：2000-12-26

申请人： Pamela B. Conley ,  Hans-Michael Jantzen ,  Vanitha Ramakrishnan-DuBridge ,  David Jay Julius ,  Gunther Hollopeter

发明人： Pamela B. Conley ,  Hans-Michael Jantzen ,  Vanitha Ramakrishnan-DuBridge ,  David Jay Julius ,  Gunther Hollopeter

IPC分类号： G01N3353

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/28 ,  G01N33/502 ,  G01N33/5091 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/02

摘要： The present invention includes a novel subtype of the P2-purinergic receptor, referred to as the P2Y12 receptor. This receptor is expressed selectively in the platelets and brain, and couples to a pertussis toxin-sensitive G protein (Gi). Nucleic acids encoding the receptor and associated screening and therapeutic methods are also disclosed.

摘要翻译： 本发明包括称为P2Y12受体的P2-嘌呤能受体的新亚型。 该受体在血小板和脑中有选择性表达，并且与百日咳毒素敏感的G蛋白（Gi）偶联。 还公开了编码受体的核酸和相关筛选和治疗方法。