公开(公告)号：US20060104997A1

公开(公告)日：2006-05-18

申请号：US10498566

申请日：2002-12-11

申请人： Panayiotis Constantinides ,  Reena Patil ,  Elijah Bolotin ,  Likan Liang

发明人： Panayiotis Constantinides ,  Reena Patil ,  Elijah Bolotin ,  Likan Liang

IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K31/337 ,  A61K31/11 ,  A61K31/045

CPC分类号： A61K9/4858 ,  A61K9/1075 ,  A61K31/045 ,  A61K31/11 ,  A61K31/337 ,  A61K47/10 ,  A61K47/22

摘要： The present invention relates to pharmaceutical compositions and methods for the mucosal and oral administration of monoterpenes and derivatives thereof. The compositions of this invention further comprise one or more surfactants and cosolvents and are in the form of self-emulsifying compositions. The compositions of the invention may further comprise water-insoluble therapeutic agents, vaccines and diagnostics. Such agents include but are not limited to taxanes, steroids, topoisomerase inhibitors such as etoposide and other water-insoluble or lipophilic drugs.

摘要翻译： 本发明涉及用于粘膜和口服单萜及其衍生物的药物组合物和方法。 本发明的组合物还包含一种或多种表面活性剂和助溶剂，并且是自乳化组合物的形式。 本发明的组合物还可包含水不溶性治疗剂，疫苗和诊断。 这些试剂包括但不限于紫杉烷类，类固醇类，拓扑异构酶抑制剂如依托泊苷和其他水不溶性或亲脂性药物。

公开(公告)号：US20060078618A1

公开(公告)日：2006-04-13

申请号：US10498572

申请日：2002-12-11

申请人： Panayiotis Constantinides ,  Reena Patil ,  Likan Liang

发明人： Panayiotis Constantinides ,  Reena Patil ,  Likan Liang

IPC分类号： A61K9/14

CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K9/127

摘要： The present invention relates to formulations and methods for the mucosal and parenteral administration of lipid particles an suspensions. The formulations of this invention are stable lipid particles useful for oral delivery of water-insoluble therapeutic agents, vaccines and diagnostics. The compositions of this invention promote the mucosal absorption of biologically active molecules across mucosal epithelial barriers. Stabilization of lipid particles is achieved by coating the hydrophobic central core with a polymer shell. The polymer shell can include bioadhesive agents, ligands, and absorption promoting agents. This invention relates to oral drug delivery systems for hydrophobic drugs, and in particular is concerned with improving the bioavailability of hydrophobic drugs from such systems. Using this system, anticancer drugs such as taxanes are orally effective.

摘要翻译： 本发明涉及用于粘膜和肠胃外给予脂质颗粒悬浮液的制剂和方法。 本发明的制剂是用于口服递送水不溶性治疗剂，疫苗和诊断的稳定的脂质颗粒。 本发明的组合物促进生物活性分子穿过粘膜上皮屏障的粘膜吸收。 脂质颗粒的稳定通过用聚合物壳涂覆疏水性中心核来实现。 聚合物壳可以包括生物粘附剂，配体和吸收促进剂。 本发明涉及用于疏水药物的口服药物递送系统，并且特别涉及提高来自这种系统的疏水性药物的生物利用度。 使用该系统，抗癌药如紫杉烷是口服有效的。