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1.发明申请公开(公告)号：US20070259961A9
公开(公告)日：2007-11-08
申请号：US10430677
申请日：2003-05-07
申请人： Partha Neogi , Debedranath Dey , Joseph Fuller , Liang Chen , Ta-Kai Li
发明人： Partha Neogi , Debedranath Dey , Joseph Fuller , Liang Chen , Ta-Kai Li
IPC分类号： A61K31/17 , C07C335/24 , C07C335/16 , C07C275/46
CPC分类号： C07C233/25 , C07C235/34 , C07C235/56 , C07C237/22 , C07C271/16 , C07C271/64 , C07C275/50 , C07C281/06 , C07C317/22 , C07C2601/14 , C07D213/56 , C07D213/643 , C07D213/75 , C07D295/185 , C07D317/60
摘要： Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.
摘要翻译： 提供新型酰基脲，硫脲，氨基甲酸酯，硫代氨基甲酸酯和相关化合物，其有效抑制培养细胞中的细胞因子介导的炎症反应，改善关节炎动物模型中的骨破坏和降低类型动物模型中的血糖水平 II型糖尿病 该化合物被公开用于各种治疗，包括治疗糖尿病，胰岛素抵抗，炎症，炎性疾病，免疫疾病和癌症。
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2.发明授权公开(公告)号：US07323496B2
公开(公告)日：2008-01-29
申请号：US10430677
申请日：2003-05-07
申请人： Partha Neogi , Debedranath Dey , Joseph Fuller , Liang Chen , Ta-Kai Li
发明人： Partha Neogi , Debedranath Dey , Joseph Fuller , Liang Chen , Ta-Kai Li
IPC分类号： A61K31/17 , C07C335/24 , C07C335/16 , C07C275/46
CPC分类号： C07C233/25 , C07C235/34 , C07C235/56 , C07C237/22 , C07C271/16 , C07C271/64 , C07C275/50 , C07C281/06 , C07C317/22 , C07C2601/14 , C07D213/56 , C07D213/643 , C07D213/75 , C07D295/185 , C07D317/60
摘要： Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.
摘要翻译： 提供新型酰基脲，硫脲，氨基甲酸酯，硫代氨基甲酸酯和相关化合物，其有效抑制培养细胞中的细胞因子介导的炎症反应，改善关节炎动物模型中的骨破坏和降低类型动物模型中的血糖水平 II型糖尿病 该化合物被公开用于各种治疗，包括治疗糖尿病，胰岛素抵抗，炎症，炎性疾病，免疫疾病和癌症。
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公开(公告)号：US20080108825A1
公开(公告)日：2008-05-08
申请号：US12004039
申请日：2007-12-20
申请人： Partha Neogi , Debedranath Dey , Joseph Fuller , Liang Chen , Ta-Kai Li
发明人： Partha Neogi , Debedranath Dey , Joseph Fuller , Liang Chen , Ta-Kai Li
IPC分类号： C07D211/00 , C07C269/00 , C07C63/00
CPC分类号： C07D295/192 , A61B5/412 , A61B5/415 , A61B5/418 , C07C233/91 , C07C235/34 , C07C235/56 , C07C275/12 , C07C275/24 , C07C275/26 , C07C281/06 , C07C335/38 , C07D213/55 , C07D213/643 , C07D213/75
摘要： Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory, diseases, immunological diseases and cancer.
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公开(公告)号：US20080103302A1
公开(公告)日：2008-05-01
申请号：US12004064
申请日：2007-12-20
申请人： Partha Neogi , Debedranath Dey , Joseph Fuller , Liang Chen , Ta-Kai Li
发明人： Partha Neogi , Debedranath Dey , Joseph Fuller , Liang Chen , Ta-Kai Li
IPC分类号： C07D265/30 , C07C59/147 , C07D241/04 , C07D211/86
CPC分类号： C07C275/50 , C07C235/34 , C07C271/16 , C07C271/64 , C07C281/06 , C07C317/22 , C07C2601/14 , C07D213/55 , C07D213/56 , C07D295/192 , C07D317/60
摘要： Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory, diseases, immunological diseases and cancer.
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5.发明申请公开(公告)号：US20080188654A1
公开(公告)日：2008-08-07
申请号：US12004075
申请日：2007-12-20
申请人： Partha Neogi , Debedranath Dey , Joseph C. Fuller , Liang Chen , Ta-Kai Li
发明人： Partha Neogi , Debedranath Dey , Joseph C. Fuller , Liang Chen , Ta-Kai Li
IPC分类号： C07D265/30 , C07C275/50 , C07D211/98 , C07D241/04 , C07C233/90
CPC分类号： C07C233/25 , C07C235/34 , C07C235/56 , C07C237/22 , C07C271/16 , C07C271/64 , C07C275/50 , C07C281/06 , C07C317/22 , C07C2601/14 , C07D213/56 , C07D213/643 , C07D213/75 , C07D295/185 , C07D317/60
摘要： Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory, diseases, immunological diseases and cancer.
摘要翻译： 提供新型酰基脲，硫脲，氨基甲酸酯，硫代氨基甲酸酯和相关化合物，其有效抑制培养细胞中的细胞因子介导的炎症反应，改善关节炎动物模型中的骨破坏和降低类型动物模型中的血糖水平 II型糖尿病 该化合物被公开用于各种治疗，包括治疗糖尿病，胰岛素抵抗，炎症，炎症，疾病，免疫疾病和癌症。
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