公开(公告)号：US07718682B2

公开(公告)日：2010-05-18

申请号：US12078662

申请日：2008-04-02

申请人： Partha Neogi ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Bishwagit Nag ,  Arthur Lee

发明人： Partha Neogi ,  Debendranath Dey ,  Satyanarayana Medicherla ,  Bishwagit Nag ,  Arthur Lee

IPC分类号： A61K31/426

CPC分类号： C07D277/20 ,  C07D277/24 ,  C07D277/34

摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.

摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。