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公开(公告)号：US07718682B2
公开(公告)日：2010-05-18
申请号：US12078662
申请日：2008-04-02
IPC分类号： A61K31/426
CPC分类号： C07D277/20 , C07D277/24 , C07D277/34
摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.
摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。
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公开(公告)号：US20080293949A1
公开(公告)日：2008-11-27
申请号：US12078662
申请日：2008-04-02
IPC分类号： C07D277/14
CPC分类号： C07D277/20 , C07D277/24 , C07D277/34
摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.
摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。
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公开(公告)号：US07202366B2
公开(公告)日：2007-04-10
申请号：US10808519
申请日：2004-03-25
IPC分类号： A61K31/41 , C07D277/60
CPC分类号： C07D277/20 , C07D277/24 , C07D277/34
摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidinedione compounds, known to lower leptin levels, the present compounds increase leptin levels and have no known liver toxicity. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.
摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 与之前报道的已知降低瘦蛋白水平的噻唑烷二酮化合物相比，本发明化合物增加瘦素水平并且没有已知的肝脏毒性。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。
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公开(公告)号：US07105552B2
公开(公告)日：2006-09-12
申请号：US09843167
申请日：2001-04-27
IPC分类号： A61K31/41
CPC分类号： C07D277/20 , C07D277/24 , C07D277/34
摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidinedione compounds, known to lower leptin levels, the present compounds increase leptin levels and have no known liver toxicity. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.
摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 与之前报道的已知降低瘦蛋白水平的噻唑烷二酮化合物相比，本发明化合物增加瘦素水平并且没有已知的肝脏毒性。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。
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公开(公告)号：US06525093B1
公开(公告)日：2003-02-25
申请号：US09436047
申请日：1999-11-08
申请人： Partha Neogi , Bishwajit Nag , Frederick J. Lakner , Debendranath Dey , Satyanarayana Medicherla
发明人： Partha Neogi , Bishwajit Nag , Frederick J. Lakner , Debendranath Dey , Satyanarayana Medicherla
IPC分类号： A01N3710
CPC分类号： C07C69/736
摘要： Compounds are provided that lower blood glucose concentrations, lower serum triglyceride concentrations, lower systolic blood pressure, and increase glucose uptake by adipose tissue, but do not affect the expression of PPAR-&ggr; by adipose tissue.
摘要翻译： 提供化合物，其降低血糖浓度，降低血清甘油三酯浓度，降低收缩压，并增加脂肪组织的葡萄糖摄取，但不影响脂肪组织中PPAR-γ的表达。
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公开(公告)号：US06331633B1
公开(公告)日：2001-12-18
申请号：US09287237
申请日：1999-04-06
IPC分类号： H61K31425
CPC分类号： C07D277/34
摘要： Novel diphenylethylene compounds containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidine compounds, known to lower leptin levels, the present compound increase leptin levels and have no known liver toxicity.
摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 与以前报道的已知降低瘦蛋白水平的噻唑烷化合物相比，本发明化合物增加瘦素水平并且没有已知的肝毒性。
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公开(公告)号：US20060235062A1
公开(公告)日：2006-10-19
申请号：US10530757
申请日：2003-10-08
IPC分类号： A61K31/426 , A61K31/421 , A61K31/4166
CPC分类号： C07D277/20 , C07D277/24 , C07D277/34
摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.
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公开(公告)号：US07407978B2
公开(公告)日：2008-08-05
申请号：US10265902
申请日：2002-10-08
IPC分类号： A61K31/425
CPC分类号： C07D277/20 , C07D277/24 , C07D277/34
摘要： Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.
摘要翻译： 提供了含有噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物，其有效降低II型糖尿病动物模型中的血糖水平，血清胰岛素，甘油三酯和游离脂肪酸水平。 所述化合物被公开用于各种治疗，包括治疗炎症，炎症和免疫疾病，胰岛素抵抗，高脂血症，冠状动脉疾病，癌症和多发性硬化。
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公开(公告)号：US20090069313A1
公开(公告)日：2009-03-12
申请号：US11896902
申请日：2007-09-06
IPC分类号： A61K31/5377 , C07D277/16 , A61K31/426 , C07D209/34 , A61P25/24 , A61P25/32 , A61P25/08 , A61P25/00 , A61P25/34 , A61P25/28 , A61K31/404 , C07D413/12 , A61K31/422
CPC分类号： C07D277/36 , C07D209/34 , C07D277/34 , C07D413/12 , C07D417/12
摘要： The present invention provides a new medical use for the compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, as MAO-A inhibitors. Also included is a method for prophylaxis and treatment of mental disorders such as depression, in a mammal, comprising administering an effective amount of a compound of formula (I). These compounds are also effective in treating a disease, condition or disorder such as weight loss, obesity, bulimia, depression, bipolar disorders, psychoses, schizophrenia, behaviors, alcoholism, tobacco abuse, memory loss, Alzheimer's disease, dementia of aging, seizure disorders, epilepsy, attention deficit disorder, and Parkinson's disease, which is modulated by a cannabinoid receptor antagonist.
摘要翻译： 本发明提供了作为MAO-A抑制剂的式（I）化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物，其代谢物和前药的新医学用途 。 还包括在哺乳动物中预防和治疗精神障碍如抑郁症的方法，包括施用有效量的式（I）化合物。 这些化合物在治疗疾病，病症或病症如体重减轻，肥胖，贪食症，抑郁症，双相性精神障碍，精神病，精神分裂症，行为，酒精中毒，吸烟，记忆丧失，阿尔茨海默病，老年痴呆，癫痫发作障碍 ，癫痫，注意力缺陷障碍和由大麻素受体拮抗剂调节的帕金森病。
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公开(公告)号：US20080319031A1
公开(公告)日：2008-12-25
申请号：US11886460
申请日：2006-03-10
申请人： Surendrakumar Satyanarayan Pandey , Shiv Kumar Agarwal , Gajendra Singh , Santhanagopalan Chithra , Sangmesh Badiger , Bishwajit Nag , Debendranath Dey , Abhijeet Nag , Partha Neogi
发明人： Surendrakumar Satyanarayan Pandey , Shiv Kumar Agarwal , Gajendra Singh , Santhanagopalan Chithra , Sangmesh Badiger , Bishwajit Nag , Debendranath Dey , Abhijeet Nag , Partha Neogi
IPC分类号： A61K31/428 , A61P3/00 , A61P29/00 , A61P37/00 , A61P35/00 , A61P3/04 , C07D209/32 , C07D277/68 , A61K31/404
CPC分类号： C07D209/34 , C07D277/68
摘要： The present invention relates to novel tyrosine derivatives of formula (I), their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel tyrosine derivatives of the general formula (I).
摘要翻译： 本发明涉及式（I）的新型酪氨酸衍生物，其药学上可接受的盐和含有它们的药学上可接受的组合物。 本发明更具体地提供了通式（I）的新型酪氨酸衍生物。
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