公开(公告)号：US20080286754A1

公开(公告)日：2008-11-20

申请号：US11933747

申请日：2007-11-01

申请人： Pascale Alfons Rosa DEHERTOGH ,  Kurt Hertogs ,  Brendan Larder ,  Dechao Wang

发明人： Pascale Alfons Rosa DEHERTOGH ,  Kurt Hertogs ,  Brendan Larder ,  Dechao Wang

IPC分类号： C12Q1/70

CPC分类号： G06F19/18 ,  G06F19/28

摘要： The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target population of HIV and the subsequent correlation of this information to phenotypic interpretation in order to correlate virus mutational profiles with drug resistance. The invention also relates to methods of utilizing the mutational profiles of the invention in databases, drug development, i.e., drug design, and drug modification, therapy and treatment design, clinical management and diagnostic analysis.

摘要翻译： 本发明提供与HIV药物的表型抗性相关的HIV-1逆转录酶和/或蛋白酶基因的新突变，突变组合或突变分布。 更具体地，本发明涉及HIV的目标群体的基因型表征的使用以及该信息随后与表型解释的相关性，以将病毒突变特征与耐药性相关联。 本发明还涉及在数据库，药物开发，即药物设计，药物修饰，治疗和治疗设计，临床管理和诊断分析中利用本发明的突变特征的方法。