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公开(公告)号：US08623831B2
公开(公告)日：2014-01-07
申请号：US13157798
申请日：2011-06-10
申请人： Patrice Denefle , Thomas F. Haws , June M. Kaplow , Marie Rosier
发明人： Patrice Denefle , Thomas F. Haws , June M. Kaplow , Marie Rosier
CPC分类号： C07K14/4705 , A61K38/00 , A61K48/00
摘要： The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.
摘要翻译： 本发明涉及能诱导NFκB的核因子κB（NFκB）诱导因子多肽（NF-κB）诱导因子多肽（NFIF多肽）。 本发明在其范围内包括NFIF多肽，包括NFIF-14b和NFIF-7a，包括编码这些多肽的cDNA，以及能够表达NFIF多肽的表达载体。 还包括用于增加患者中NFkappaB诱导的方法和组合物，用于降低患者中NFkappaB诱导的方法和组合物，用于抑制炎症的方法和用于制备用于治疗和/或预防NFκB调节的药物的方法 炎症反应。 此外，提供了用于确定测试化合物是否抑制或增强NFIF多肽的活性的方法。
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公开(公告)号：US08642739B2
公开(公告)日：2014-02-04
申请号：US13157815
申请日：2011-06-10
申请人： Patrice Denefle , Thomas F. Haws , June M. Kaplow , Marie Rosier
发明人： Patrice Denefle , Thomas F. Haws , June M. Kaplow , Marie Rosier
IPC分类号： C07K14/00
CPC分类号： C07K14/4705 , A61K38/00 , A61K48/00
摘要： The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.
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