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    Nuclear factor κB inducing factor
    1.
    发明授权
    Nuclear factor κB inducing factor 有权
    核因子κB诱导因子

    公开(公告)号：US08623831B2

    公开(公告)日：2014-01-07

    申请号：US13157798

    申请日：2011-06-10

    申请人： Patrice Denefle ,  Thomas F. Haws ,  June M. Kaplow ,  Marie Rosier

    发明人： Patrice Denefle ,  Thomas F. Haws ,  June M. Kaplow ,  Marie Rosier

    IPC分类号： A61K38/17 ,  C07K14/47

    CPC分类号： C07K14/4705 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.

    摘要翻译： 本发明涉及能诱导NFκB的核因子κB（NFκB）诱导因子多肽（NF-κB）诱导因子多肽（NFIF多肽）。 本发明在其范围内包括NFIF多肽，包括NFIF-14b和NFIF-7a，包括编码这些多肽的cDNA，以及能够表达NFIF多肽的表达载体。 还包括用于增加患者中NFkappaB诱导的方法和组合物，用于降低患者中NFkappaB诱导的方法和组合物，用于抑制炎症的方法和用于制备用于治疗和/或预防NFκB调节的药物的方法 炎症反应。 此外，提供了用于确定测试化合物是否抑制或增强NFIF多肽的活性的方法。

    Nuclear factor κB inducing factor
    2.
    发明授权
    Nuclear factor κB inducing factor 有权

    公开(公告)号：US08642739B2

    公开(公告)日：2014-02-04

    申请号：US13157815

    申请日：2011-06-10

    申请人： Patrice Denefle ,  Thomas F. Haws ,  June M. Kaplow ,  Marie Rosier

    发明人： Patrice Denefle ,  Thomas F. Haws ,  June M. Kaplow ,  Marie Rosier

    IPC分类号： C07K14/00

    CPC分类号： C07K14/4705 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.

    Nuclear factor κB inducing factor
    4.
    发明授权
    Nuclear factor κB inducing factor 有权
    核因子和kgr B诱导因子

    公开(公告)号：US07972844B2

    公开(公告)日：2011-07-05

    申请号：US11354560

    申请日：2006-02-15

    申请人： June Kaplow ,  Thomas Haws ,  Marie Rosier ,  Patrice Denefle

    发明人： June Kaplow ,  Thomas Haws ,  Marie Rosier ,  Patrice Denefle

    IPC分类号： C12N5/00 ,  C12N15/00 ,  C07H21/02 ,  C12P21/06

    CPC分类号： C07K14/4705 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.

    摘要翻译： 本发明涉及能够诱导NF＆B的诱导因子多肽（NFIF）的核因子B（NF＆kgr; B）诱导因子多肽（NFIF）。 本发明在其范围内包括NFIF多肽，包括NFIF-14b和NFIF-7a，包括编码这些多肽的cDNA，以及能够表达NFIF多肽的表达载体。 还包括用于增加患者中NF和κB诱导的方法和组合物，用于降低患者中NF＆kgr B诱导的方法和组合物，用于抑制炎症的方法和用于制备用于治疗和/或预防 NF和kgr B调节的炎症反应。 此外，提供了用于确定测试化合物是否抑制或增强NFIF多肽的活性的方法。

    Nuclear factor kappaB inducing factor
    5.
    发明申请
    Nuclear factor kappaB inducing factor 有权

    公开(公告)号：US20060223771A1

    公开(公告)日：2006-10-05

    申请号：US11354560

    申请日：2006-02-15

    申请人： June Kaplow ,  Thomas Haws ,  Marie Rosier ,  Patrice Denefle

    发明人： June Kaplow ,  Thomas Haws ,  Marie Rosier ,  Patrice Denefle

    IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/53 ,  C07H21/02 ,  C07K14/475 ,  A61K38/18

    CPC分类号： C07K14/4705 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacutre of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.

    Nuclear factor κB inducing factor
    6.
    发明授权
    Nuclear factor κB inducing factor 有权
    核因子κB诱导因子

    公开(公告)号：US07041497B2

    公开(公告)日：2006-05-09

    申请号：US09823119

    申请日：2001-03-30

    申请人： June Kaplow ,  Thomas Haws ,  Marie Rosier ,  Patrice Denefle

    发明人： June Kaplow ,  Thomas Haws ,  Marie Rosier ,  Patrice Denefle

    IPC分类号： C12N5/00 ,  C07H21/00 ,  C12P21/06

    CPC分类号： C07K14/4705 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.

    摘要翻译： 本发明涉及能诱导NFκB的核因子κB（NFκB）诱导因子多肽（NF-κB）诱导因子多肽（NFIF多肽）。 本发明在其范围内包括NFIF多肽，包括NFIF-14b和NFIF-7a，包括编码这些多肽的cDNA，以及能够表达NFIF多肽的表达载体。 还包括用于增加患者中NFkappaB诱导的方法和组合物，用于降低患者中NFkappaB诱导的方法和组合物，用于抑制炎症的方法和用于制备用于治疗和/或预防NFκB调节的药物的方法 炎症反应。 此外，提供了用于确定测试化合物是否抑制或增强NFIF多肽的活性的方法。