公开(公告)号：US20080015448A1

公开(公告)日：2008-01-17

申请号：US11766321

申请日：2007-06-21

申请人： Patricia Keely ,  Paolo Provenzano ,  John White ,  Kevin Eliceiri

发明人： Patricia Keely ,  Paolo Provenzano ,  John White ,  Kevin Eliceiri

IPC分类号： A61B6/00

CPC分类号： A61B5/4312 ,  A61B5/0068 ,  A61B5/0091 ,  A61B5/726 ,  A61B6/502 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/30068 ,  G06T2207/30096 ,  G06T2207/30101

摘要： The present invention provides methods and systems for evaluating biological materials for the diagnosis of disease, such as gland abnormalities, and the cancerous and precancerous conditions. Nonlinear optical microscopy techniques, such as MP microscopy and harmonic generation microscopy, are used to generate high resolution, three dimensional images of a test tissue, such as a biopsy tissue sample and tissue in whole organisms, that are analyzed, optionally in combination, to detect, identify and characterize tumor-associated collagen signatures. The presence, abundance and extent of histological features and structural motifs comprising tumor-associated collagen signatures may be directly and accurately correlated with the onset and progression of cancer, such as breast cancer. The present methods are capable of providing an accurate and selective diagnosis of cancer, and provide diagnostic information complementary to conventional diagnostic methods.

摘要翻译： 本发明提供了用于评估生物材料用于诊断疾病如胃体异常以及癌和癌前病症的方法和系统。 使用非线性光学显微术技术，例如MP显微镜和谐波生成显微镜，以产生测试组织的高分辨率三维图像，例如活检组织样本和整个生物体中的组织，其可选地组合分析至 检测，识别和表征肿瘤相关胶原蛋白的特征。 包括肿瘤相关胶原特征的组织学特征和结构基序的存在，丰度和程度可以直接和准确地与癌症如乳腺癌的发病和进展相关。 本发明的方法能够提供对癌症的准确和选择性诊断，并提供与常规诊断方法互补的诊断信息。

公开(公告)号：US20050074800A1

公开(公告)日：2005-04-07

申请号：US10929919

申请日：2004-08-30

申请人： Peter Muir ,  Ray Vanderby ,  Paolo Provenzano

发明人： Peter Muir ,  Ray Vanderby ,  Paolo Provenzano

IPC分类号： C12Q1/68 ,  G01N33/573 ,  G01N33/68 ,  C12Q1/37

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G01N33/573 ,  G01N33/6887 ,  G01N2333/916 ,  G01N2333/96466 ,  G01N2800/102

摘要： Disclosed are methods for detecting and treating joint disease. The methods of diagnosis include determining increased expression of enzymes that are upregulated during the progress of joint and ligament inflammation and degeneration. In addition, disclosed are methods of treating the disease including inhibiting the activity of responsible proteases.

摘要翻译： 公开了检测和治疗关节疾病的方法。 诊断方法包括确定在关节和韧带炎症和退行进展期间上调的酶的增加的表达。 此外，公开了治疗疾病的方法，包括抑制负责任的蛋白酶的活性。