利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

17 条记录 (耗时 0.024 秒)

    Method for producing a pricking element
    1.
    发明授权
    Method for producing a pricking element 有权
    穿刺元件的制造方法

    公开(公告)号：US08087141B2

    公开(公告)日：2012-01-03

    申请号：US11763266

    申请日：2007-06-14

    申请人： Patrick Griss ,  Marzellinus Zipfel ,  Angel Lopez

    发明人： Patrick Griss ,  Marzellinus Zipfel ,  Angel Lopez

    IPC分类号： B21D53/00

    CPC分类号： A61M37/00 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150419 ,  A61B5/15105 ,  A61B5/15142 ,  Y10T29/302 ,  Y10T29/304 ,  Y10T29/49812 ,  Y10T29/49995 ,  Y10T29/53339 ,  Y10T428/12188

    摘要： The sheet metal or substrate material 22 is constructed by a photo-chemical machining or milling method. In this exemplary process, an etching mask 24 is applied to both sides of the substrate 22 and covers the structure of the flat-shaped member 12, which is to be uncovered in a subsequent etching step. The mask 24 is formed by coating the substrate 22 with a photoresist and is exposed through a photomask having the desired pattern that is arranged in front of the mask, whereby the photoresist is polymerized or hardened in the covered areas while the other areas are rinsed away after development.

    摘要翻译： 金属板或基板材料22通过光化学加工或研磨方法构成。 在该示例性工艺中，将蚀刻掩模24施加到基板22的两侧，并且覆盖在随后的蚀刻步骤中未被覆盖的平坦形构件12的结构。 掩模24通过用光致抗蚀剂涂覆基板22而形成，并且通过布置在掩模前面的具有所需图案的光掩模曝光，由此光致抗蚀剂在覆盖区域聚合或硬化，而其它区域被冲洗掉 后发展。

    METHOD FOR PRODUCING A PRICKING ELEMENT
    2.
    发明申请
    METHOD FOR PRODUCING A PRICKING ELEMENT 有权
    生产元素的方法

    公开(公告)号：US20080040919A1

    公开(公告)日：2008-02-21

    申请号：US11763266

    申请日：2007-06-14

    申请人： Patrick Griss ,  Marzellinus Zipfel ,  Angel Lopez

    发明人： Patrick Griss ,  Marzellinus Zipfel ,  Angel Lopez

    IPC分类号： A61B17/34

    CPC分类号： A61M37/00 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150419 ,  A61B5/15105 ,  A61B5/15142 ,  Y10T29/302 ,  Y10T29/304 ,  Y10T29/49812 ,  Y10T29/49995 ,  Y10T29/53339 ,  Y10T428/12188

    摘要： The present invention provides a process for producing a lancing element in which a flat-shaped member is formed from a flat material by applying a mask and allowing an etching agent to act upon it, wherein at least a part of the flat-shaped member is shaped as a tip. The mask is provided with a shaping area for the tip to be formed and with a screening area which extends distally beyond this shaping area to prevent the tip from being etched off at the front. A sharp tip is exposed by laterally undercutting the side flanks of the shaping area and screening area.

    摘要翻译： 本发明提供一种用于制造穿刺元件的方法，其中通过施加掩模并使蚀刻剂作用于平坦材料而形成平坦部件，其中，平坦部件的至少一部分为 形状为尖端。 掩模设置有用于要形成的尖端的成形区域和具有远离该成形区域延伸的遮蔽区域，以防止尖端在前部被蚀刻掉。 尖锐的尖端通过横向底切成形区域的侧面和筛选区域而暴露。

    Modular machine tool for series machining of parts in a bar
    4.
    发明授权
    Modular machine tool for series machining of parts in a bar 失效
    模块化机床，用于在棒中进行零件加工

    公开(公告)号：US4679295A

    公开(公告)日：1987-07-14

    申请号：US879102

    申请日：1986-05-30

    申请人： Angel Lopez

    发明人： Angel Lopez

    IPC分类号： B23Q1/00 ,  B23Q1/01 ,  B23Q1/48 ,  B23Q1/70 ,  B23Q37/00 ,  B23Q41/04 ,  B23P23/00 ,  B23Q7/04

    CPC分类号： B23Q41/04 ,  B23Q37/00 ,  Y10T29/5142 ,  Y10T29/5145 ,  Y10T408/54 ,  Y10T409/304088 ,  Y10T409/30532 ,  Y10T409/306048

    摘要： The machine tool comprises one or several modules comprising a rigid chassis formed of a lower tubular frame (11) and an upper tubular frame (12). The lower frame forms a case containing a lubricating unit and an apparatus for the removal of chips (17). The upper frame (12) has the form of a prism of which two sides (18 and 19) in the form of isoceles triangles are connected by a connecting beam (20) of square section whose faces are inclined at 45.degree. with respect to the vertical. A mobile swivel support (23) is disposed astride the connecting beam (20). This swivel support carries two machining units (24 and 25) mounted symmetrically with respect to the axis (27) of a bar of raw material. Each machining unit comprises a spindle (28) actuated by a motor (29) and a device for displacing the spindle along three axes. The swivel support (23) may be turned around on the beam (20). It may also be prepared beforehand and programmed on a module outside the machine.

    摘要翻译： PCT No.PCT / CH85 / 00153 Sec。 371日期：1986年5月30日 102（e）日期1986年5月30日PCT提交1985年10月11日PCT公布。 出版物WO86 / 02305 日期：1986年04月24日。机床包括一个或多个模块，其包括由下管状框架（11）和上管状框架（12）形成的刚性底盘。 下框架形成容纳润滑单元的壳体和用于去除切屑的装置（17）。 上框架（12）具有棱柱的形式，其中以等角三角形形式的两侧（18和19）通过方形截面的连接梁（20）连接，其面相对于 垂直。 移动式旋转支架（23）跨越连接梁（20）设置。 该旋转支撑件承载相对于原料棒的轴线（27）对称安装的两个加工单元（24和25）。 每个加工单元包括由马达（29）致动的主轴（28）和用于沿着三个轴移动主轴的装置。 旋转支撑件（23）可以在梁（20）上转动。 也可以事先准备并在机器外的模块上进行编程。

    Method of modulating leukemic cell and eosinphil activity with monoclonal antibodies
    5.
    发明授权
    Method of modulating leukemic cell and eosinphil activity with monoclonal antibodies 有权
    用单克隆抗体调节白血病细胞和嗜酸性粒细胞活性的方法

    公开(公告)号：US07427401B2

    公开(公告)日：2008-09-23

    申请号：US10774887

    申请日：2004-02-09

    申请人： Angel Lopez ,  Richard D'Andrea

    发明人： Angel Lopez ,  Richard D'Andrea

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/73

    摘要： A method of isolating a monoclonal antibody capable of inhibiting any one of IL-3, GM-CSF and IL-5 binding to the common receptor βc, or a monoclonal antibody capable of inhibiting the cytokines binding to a receptor analogous to βc. The method includes the steps of immunizing an animal with a cytokine receptor or portion of a cytokine containing the critical binding site which portion includes the extracellular domain 4 or analogous domain in the analogous common receptor or part thereof. Antibodies producing cells from the animal are then isolated and fused with a myeloma cell line and then screened for a cell line that produces an antibody of the desired type. A monoclonal antibody, or fragments thereof capable of inhibiting the binding of the cytokines IL-3, GM-CSF and IL-5 to the βc receptor, and a hybridoma cell line producing the antibody are also claimed.

    摘要翻译： 分离能够抑制与常见受体β1结合的IL-3，GM-CSF和IL-5中的任一种的单克隆抗体的方法，或能够抑制细胞因子结合的单克隆抗体 类似于β的受体。 该方法包括以下步骤：用细胞因子受体或包含关键结合位点的细胞因子部分免疫动物，该部分包括类似的共同受体或其部分的细胞外结构域4或类似结构域。 然后分离从动物产生细胞的抗体并与骨髓瘤细胞系融合，然后筛选产生所需类型的抗体的细胞系。 还要求能够抑制细胞因子IL-3，GM-CSF和IL-5与β受体的结合的单克隆抗体或其片段，以及产生抗体的杂交瘤细胞系 。

    Binding motif and methods of regulating cell function
    6.
    发明申请
    Binding motif and methods of regulating cell function 审中-公开
    结合基序和调节细胞功能的方法

    公开(公告)号：US20070059796A1

    公开(公告)日：2007-03-15

    申请号：US10595559

    申请日：2004-10-27

    申请人： Mark Guthridge ,  Hayley Ramshaw ,  Frank Stomski ,  Angel Lopez

    发明人： Mark Guthridge ,  Hayley Ramshaw ,  Frank Stomski ,  Angel Lopez

    IPC分类号： A61K38/17 ,  C07K14/715 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K5/1021 ,  A61K38/00 ,  C07K14/435 ,  C07K14/715 ,  C07K14/7153

    摘要： The present invention relates to a binding motif and methods of regulating cell function which methods target a single amino acid residue preferably a Tyr in a binding motif equivalent to a motif of the common beta chain (βc) of the GM-CSF/IL-3/IL-5 receptor. Preferably, the cell functions affect cell survival and proliferation in cells. The methods can be used for treatments of conditions relating to cell survival and proliferation and can be used to expand progenitor cells, for instance, for transplantation purposes.

    摘要翻译： 本发明涉及结合基序和调节细胞功能的方法，该方法靶向单个氨基酸残基，优选与等价于GM-CSF / IL-3的常见β链（betac）基序的结合基序中的Tyr / IL-5受体。 优选地，细胞功能影响细胞中的细胞存活和增殖。 该方法可用于治疗与细胞存活和增殖有关的病症，并且可用于扩增祖细胞，例如用于移植目的。

    BIDENTATE MOTIF AND METHODS OF USE
    8.
    发明申请
    BIDENTATE MOTIF AND METHODS OF USE 审中-公开

    公开(公告)号：US20070219117A1

    公开(公告)日：2007-09-20

    申请号：US10595562

    申请日：2004-10-27

    申请人： Mark Guthridge ,  Hayley Ramshaw ,  Frank Stomski ,  Fernando Felquer ,  Angel Lopez

    发明人： Mark Guthridge ,  Hayley Ramshaw ,  Frank Stomski ,  Fernando Felquer ,  Angel Lopez

    IPC分类号： C07K2/00

    CPC分类号： C07K14/435 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7153

    摘要： The present invention relates to a novel bidentate motif that is composed of two adjacent residues of tyrosine and serine which have been found to be involved in the binding of crucial cytoplasmic proteins which are involved in cell signalling pathways. In some cases, the cytoplasmic proteins are ubiquitous proteins involved in cell signalling pathways that may include mitogenesis, transformation and survival. The bidentate motif may have a sequence alignment (SEQ ID NO: 71) N-X-X-Y- (X) 1-13-[R/K/H/Q]-[X/Ψ] 2-3-S/T-X-P; (SEQ ID NO: 72) Y- (X) 1-16-[R/K/H/Q]-[X/Ψ] 2-3-S/T-X-P; or (SEQ ID NO: 73) N-X-X-Y-[X]1-30-[R/K/Q/H]-[X]1-4-[S/T]-X-p wherein X is any residue, Y is tyrosine, S/T is serine or threonine and Ψ is a hydrophobic residue or an equivalent thereof. Preferably the residues are Tyr577 and Ser585 of the common βc of the GM-CSF/IL-5/IL-3 receptor.

    Therapeutic agents as cytokine antagonists and agonists
    9.
    再颁专利
    Therapeutic agents as cytokine antagonists and agonists 失效
    作为细胞因子拮抗剂和激动剂的治疗剂

    公开(公告)号：USRE39433E1

    公开(公告)日：2006-12-19

    申请号：US10386813

    申请日：1997-01-29

    申请人： Angel Lopez ,  Christopher Bagley ,  Joanna Woodcock

    发明人： Angel Lopez ,  Christopher Bagley ,  Joanna Woodcock

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C07K16/28

    CPC分类号： C07K16/2866 ,  A61K38/00 ,  C07K14/70503 ,  C07K14/715 ,  C07K14/7153 ,  C07K14/7155

    摘要： A therapeutic agent capable of of binding to the F′-G′ loop of domain 4 of the common c Chain of the receptor for GM-CSF, IL-3, and IL-5. The amino acid Tyr421 which is located in the F′-G′ loop is critical in the high affinity binding and stimulation of function of GM-CSF, IL-3 and IL-5 to the common c chain of the receptors. Other receptors for cytokines also show hydrophobic amino acids in analogous positions and it is probable that they too play a pivotal role in binding of respective cytokines to them and in modulating function. Agents capable of binding to the F′-G′ loops are suggested and should be of therapeutic value.

    摘要翻译： 能够结合GM-CSF，IL-3和IL-5受体的共同链的结构域4的F'-G'环的治疗剂。 位于F'-G'环中的氨基酸Tyr 421在高亲和力结合和刺激GM-CSF，IL-3和IL-5的功能至关重要， 受体的链。 细胞因子的其他受体也显示类似位置的疏水性氨基酸，并且它们在结合相应的细胞因子和调节功能中也可能起关键作用。 提出能够结合F'-G'环的试剂，应具有治疗价值。