公开(公告)号：US5552416A

公开(公告)日：1996-09-03

申请号：US422388

申请日：1995-04-14

申请人： Patrick Keohane

发明人： Patrick Keohane

IPC分类号： C07D333/56 ,  A61K31/38 ,  A61K31/40 ,  A61K31/445 ,  A61P13/02 ,  A61P15/00

CPC分类号： A61K31/445 ,  A61K31/40

摘要： A method of inhibiting dysfunctional uterine bleeding comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidine, hexamethylenemino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

公开(公告)号：US5446053A

公开(公告)日：1995-08-29

申请号：US171391

申请日：1993-12-21

申请人： Patrick Keohane

发明人： Patrick Keohane

IPC分类号： C07D333/56 ,  A61K31/38 ,  A61K31/40 ,  A61K31/445 ,  A61P13/02 ,  A61P15/00

CPC分类号： A61K31/445 ,  A61K31/40

摘要： A method of inhibiting dysfunctional uterine bleeding comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidine, hexamethylenemino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

摘要翻译： 抑制功能障碍性子宫出血的方法包括向有需要的人施用有效量的具有式（I）的化合物，其中R 1和R 3独立地为氢，其中Ar为任选取代的苯基; R2选自吡咯烷，六亚甲基二胺和哌啶子基; 或其药学上可接受的盐的溶剂合物。