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1.发明申请公开(公告)号：US20210252125A1
公开(公告)日：2021-08-19
申请号：US17049245
申请日：2019-04-25
申请人： Patrick Leonard AHL , Akhilesh BHAMBHANI , Christopher Jon FARRELL , Patrick MCHUGH , Morrisa C. JONES , Daniel D. ROTH , Jessica R. SINACOLA , Justin STANBRO , Matthew P. WATSON , Emily WEN , Michael A. WINTERS , Merck Sharp & Dohme Corp.
发明人： Patrick Leonard Ahl , Akhilesh Bhambhani , Christopher Jon Farrell , Patrick McHugh , Morrisa C. Jones , Daniel D. Roth , Jessica R. Sinacola , Justin Stanbro , Matthew P. Watson , Emily Wen , Michael A. Winters
摘要： A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.
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公开(公告)号：US20210252126A1
公开(公告)日：2021-08-19
申请号：US17049266
申请日：2019-04-25
发明人： Patrick Leonard Ahl , Akhilesh Bhambhani , Christopher Jon Farrell , Patrick McHugh , Morrisa C. Jones , Daniel D. Roth , Jessica R. Sinacola , Justin Stanbro , Matthew P. Watson , Emily Wen , Michael A. Winters
摘要： A method is described for reconstituting lyophilized mutant diphtheria toxin in dimethyl sulfoxide for use in producing pneumococcal capsular polysaccharide mutant diphtheria toxin conjugates.
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