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1.发明申请SUSTAINED RELEASE INTRAOCULAR IMPLANTS CONTAINING TYROSINE KINASE INHIBITORS AND RELATED METHODS 有权含有酪氨酸激酶抑制剂的持续释放内皮植入物及相关方法公开(公告)号：US20080254096A1
公开(公告)日：2008-10-16
申请号：US12029425
申请日：2008-02-11
申请人： Patrick M. HUGHES , Thomas C. MALONE , Gerald W. DE VRIES , Jeffery L. EDELMAN , Joan-En CHANG-LIN , Jane Guo SHIAH , Thierry NIVAGGIOLI
发明人： Patrick M. HUGHES , Thomas C. MALONE , Gerald W. DE VRIES , Jeffery L. EDELMAN , Joan-En CHANG-LIN , Jane Guo SHIAH , Thierry NIVAGGIOLI
CPC分类号： A61K9/0051 , A61K9/1647 , Y10T428/2985
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.
摘要翻译： 生物相容性眼内植入物包括酪氨酸激酶抑制剂和生物可降解聚合物，其有效促进酪氨酸激酶抑制剂长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生。
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2.发明申请SUSTAINED RELEASE INTRAOCULAR INPLANTS CONTAINING TYROSINE KINASE INHIBITORS AND RELATED METHODS 有权含有酪氨酸激酶抑制剂的持续释放内分泌物及相关方法公开(公告)号：US20080260803A1
公开(公告)日：2008-10-23
申请号：US12029424
申请日：2008-02-11
申请人： Patrick M. HUGHES , Thomas C. MALONE , Gerald W. DE VRIES , Jeffery L. EDELMAN , Joan-En CHANG-LIN , Jane-Guo SHIAH , Thierry NIVAGGIOLI
发明人： Patrick M. HUGHES , Thomas C. MALONE , Gerald W. DE VRIES , Jeffery L. EDELMAN , Joan-En CHANG-LIN , Jane-Guo SHIAH , Thierry NIVAGGIOLI
IPC分类号： A61F2/00
CPC分类号： A61K9/0051 , A61K9/1647 , Y10T428/2985
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.
摘要翻译： 生物相容性眼内植入物包括酪氨酸激酶抑制剂和生物可降解聚合物，其有效促进酪氨酸激酶抑制剂长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生。
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公开(公告)号：US20080241223A1
公开(公告)日：2008-10-02
申请号：US12113434
申请日：2008-05-01
申请人： Thierry NIVAGGIOLI , Jane Guo Shiah , Qing Lin
发明人： Thierry NIVAGGIOLI , Jane Guo Shiah , Qing Lin
CPC分类号： A61K9/0051 , A61K9/204 , A61K31/57 , A61K31/573 , A61K47/34
摘要： Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.
摘要翻译： 尺寸适于植入眼部或部位的可生物降解植入物以及用于治疗眼部病症的方法。 植入物以治疗有效量提供活性剂的延长释放一段时间在50天至1年或更长时间之间。
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公开(公告)号：US20110305743A1
公开(公告)日：2011-12-15
申请号：US13213473
申请日：2011-08-19
申请人： Jane-Guo SHIAH , Rahul BHAGAT , Wendy M. BLANDA , Thierry NIVAGGIOLI , Lin PENG , David CHOU , David A. WEBER
发明人： Jane-Guo SHIAH , Rahul BHAGAT , Wendy M. BLANDA , Thierry NIVAGGIOLI , Lin PENG , David CHOU , David A. WEBER
IPC分类号： A61F2/00 , A61P27/02 , A61P31/04 , A61P29/00 , A61P31/12 , A61P31/10 , A61P3/10 , A61K31/56 , A61P35/00
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
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5.发明申请FORMULATIONS AND METHODS FOR VASCULAR PERMEABILITY-RELATED DISEASES OR CONDITIONS 有权用于血管渗透性相关疾病或病症的制剂和方法公开(公告)号：US20120329759A1
公开(公告)日：2012-12-27
申请号：US13530025
申请日：2012-06-21
IPC分类号： A61K31/436 , A61P29/00 , A61P27/02 , A61P9/00 , A61K31/675
CPC分类号： A61K31/436 , A61K47/10
摘要： Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.
摘要翻译： 本文描述了用于治疗，抑制，预防，延缓发作或导致与血管通透性有关的疾病或病症消退的制剂和方法。
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