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公开(公告)号：US06224908B1
公开(公告)日：2001-05-01
申请号：US09577041
申请日：2000-05-24
申请人： Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
发明人： Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
IPC分类号： A61K924
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： Oral active agent delivery system having improved flow controllers. A hollow tubular member containing the active agent formulation and having a fluid passing controller is placed at one end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.
摘要翻译： 具有改进的流量控制器的口服活性剂递送系统。 含有活性剂制剂并具有流体通过控制器的空心管状构件一端放置在流体中，并在第二端放入患者口中。 当患者唾液在腔室的末端时，递送活性剂。 改进的控制器防止活性剂制剂的泄漏。
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公开(公告)号：US6103265A
公开(公告)日：2000-08-15
申请号：US401610
申请日：1999-09-22
申请人： Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
发明人： Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.
摘要翻译： 本发明涉及包含改进的流量控制器的口服活性剂递送系统。 含有活性剂制剂并具有流体通过控制器（14）的中空管状构件（10）在一端（16）处放置成流体，并在第二端（18）放置到患者口中。 当患者唾液在腔室的末端时，递送活性剂。 改进的控制器防止活性剂制剂的泄漏。
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公开(公告)号：US5985324A
公开(公告)日：1999-11-16
申请号：US73982
申请日：1998-05-07
申请人： Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
发明人： Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.
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公开(公告)号：US6096003A
公开(公告)日：2000-08-01
申请号：US950016
申请日：1997-10-14
申请人： Patrick S.-L. Wong , James Horvath , Radomir N. M. Vukadin , Joyce C. Anthony , Vincent J. Ferrari , Jeffrey W. Etter , Christopher M. G. Ohms
发明人： Patrick S.-L. Wong , James Horvath , Radomir N. M. Vukadin , Joyce C. Anthony , Vincent J. Ferrari , Jeffrey W. Etter , Christopher M. G. Ohms
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： The present invention is directed to a closure system for an oral active agent delivery device. The device comprises an elongate tubular member having first and second ends. The closure system includes a deformable closure means adapted to allow delivery of the active agent upon deformation. The closure system prevents spillage and maintains the integrity of the dose within the device. In use, the closure system is deformed and separated from the second end of the tubular member, liquid is drawn up into the first end of the member, and the liquid and active agent are drawn out of the second end of the member and into the patient's mouth.
摘要翻译： 本发明涉及用于口服活性剂递送装置的封闭系统。 该装置包括具有第一端和第二端的细长管状构件。 闭合系统包括适于允许活化剂在变形时输送的可变形闭合装置。 闭合系统防止溢出并维持装置内剂量的完整性。 在使用中，封闭系统变形并与管状构件的第二端分离，液体被拉入构件的第一端，并且液体和活性剂从构件的第二端被拉出并进入 病人的嘴。
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公开(公告)号：US5910321A
公开(公告)日：1999-06-08
申请号：US949753
申请日：1997-10-14
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0004
摘要： The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member having first and second ends comprises first and second flow paths. Either or both of said flow paths contains an active agent. Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.
摘要翻译： 本发明涉及一种口服活性剂递送系统和用于将活性剂的离散单元递送给患者的方法。 具有第一和第二端的细长管状构件包括第一和第二流动路径。 所述流路中的任一个或两者包含活性剂。 液体被吸入构件的第一端，液体和活性剂被从构件的第二端引出并进入患者的口中。
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6.发明授权Active agent dosage form comprising a matrix and at least two insoluble bands 失效包含基质和至少两个不溶性条带的活性剂剂型
公开(公告)号：US5534263A
公开(公告)日：1996-07-09
申请号：US394074
申请日：1995-02-24
CPC分类号： A61K9/2072
摘要： The present invention is directed to an active agent dosage form which is useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a matrix that has on its surface two or more insoluble bands. The invention is also directed to the method for making the active agent dosage form.
摘要翻译： 本发明涉及一种活性剂剂型，其可用于将活性剂制剂延长递送至使用的流体环境。 活性剂剂型是其表面上具有两个或多个不溶性带的基质。 本发明还涉及制备活性剂剂型的方法。
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公开(公告)号：US6153678A
公开(公告)日：2000-11-28
申请号：US167372
申请日：1998-10-06
申请人： Liang-Chang Dong , Crystal Pollock , Patrick S.-L. Wong , Keru O. Shafi , Vincent J. Ferrari , Ted Smith
发明人： Liang-Chang Dong , Crystal Pollock , Patrick S.-L. Wong , Keru O. Shafi , Vincent J. Ferrari , Ted Smith
CPC分类号： C08L71/02 , A61K9/0004 , C08L67/04
摘要： Polymeric compositions are disclosed comprising a poly(caprolactone), a poly(alkylene oxide), a poly(oxyethylenated fatty acid ester), or a poly(oxyethylenated fatty acid), or a poly(oxyethylene-co-oxypropylene).
摘要翻译： 公开了包含聚（己内酯），聚（环氧烷），聚（氧乙烯化脂肪酸酯）或聚（氧乙烯化脂肪酸）或聚（氧乙烯 - 共 - 氧丙烯）的聚合物组合物。
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公开(公告)号：US6024721A
公开(公告)日：2000-02-15
申请号：US950424
申请日：1997-10-15
CPC分类号： A61J1/2093 , A61J7/0038
摘要： The present invention is directed to a mixing system for an active agent delivery device. The device comprises an elongate tubular member having first and second ends and a mixing system. The mixing system enables the entire dose of active agent to be entrained in a liquid. In use, liquid is drawn into the first end of the device, the mixing system mixes the liquid and active agent within the device and the active agent entrained in the liquid is drawn out of the second end of the member and into the patient's mouth.
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9.发明授权Osmotic device with high drug loading and delayed activation of drug delivery 失效渗透装置具有高药物负荷和药物递送延迟激活
公开(公告)号：US5817335A
公开(公告)日：1998-10-06
申请号：US451647
申请日：1995-05-26
CPC分类号： A61K9/0004 , Y10S514/962
摘要： The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation being of a predetermined length of time. The dispensing device is formed of a first and second housing that are in reversibly sliding telescoping arrangement with each other. The first housing contains the active agent formulation and has an aspect ratio less than 1. The housings are preferably. ovoloid in shape.
摘要翻译： 本发明涉及一种流体吸收药物递送装置，其用于将活性剂制剂初始延迟递送至使用的流体环境，起始或启动的初始延迟时间为预定时间长度。 分配装置由彼此可逆地滑动伸缩布置的第一和第二壳体形成。 第一壳体包含活性剂制剂并且具有小于1的纵横比。该外壳是优选的。 ovoloid形状。
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公开(公告)号：US06210713B1
公开(公告)日：2001-04-03
申请号：US09513074
申请日：2000-02-25
IPC分类号： A61K914
CPC分类号： A61K9/0092 , A47G21/183 , A61J7/0038
摘要： The present invention is an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.
摘要翻译： 本发明是一种口服活性剂递送系统和用于将活性剂制剂的离散单元递送给患者的方法。 含有活性剂制剂并具有流体通过的活性剂制剂保持剂的活性剂制剂室在第一端置于流体中，并在第二端置于患者口中。 当患者在房间的第二端上浸泡时，递送活性剂。
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