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公开(公告)号：US20130273543A1
公开(公告)日：2013-10-17
申请号：US13997037
申请日：2011-12-20
申请人： Julius Gudmundsson , Patrick Sulem
发明人： Julius Gudmundsson , Patrick Sulem
CPC分类号： G16B30/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： The invention discloses genetic variants that have been determined to be susceptibility variants of thyroid cancer. Methods of disease management, including methods of determining susceptibility to thyroid cancer, methods of predicting response to therapy and methods of predicting prognosis of thyroid cancer using such variants are described. The invention further relates to kits useful in the methods of the invention.
摘要翻译： 本发明公开了已被确定为甲状腺癌易感性变异体的遗传变异体。 描述了疾病管理方法，包括确定甲状腺癌易感性的方法，预测治疗反应的方法和使用这些变体预测甲状腺癌预后的方法。 本发明还涉及可用于本发明方法的试剂盒。
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公开(公告)号：US20090317799A1
公开(公告)日：2009-12-24
申请号：US11920590
申请日：2006-05-18
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： A locus on chromosome 8q24.21 has been demonstrated to play a major role in particular forms of cancer. It has been discovered that certain markers and haplotypes are indicative of a susceptibility to particular cancers. Diagnostic applications for identifying susceptibilty to cancer are described.
摘要翻译： 已经证明染色体8q24.21上的位点在特定形式的癌症中起主要作用。 已经发现某些标记和单体型表示对特定癌症的易感性。 描述了鉴定癌症易感性的诊断应用。
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公开(公告)号：US20170191134A1
公开(公告)日：2017-07-06
申请号：US15231157
申请日：2016-08-08
IPC分类号： C12Q1/68 , A61N5/10 , G01N33/574
CPC分类号： C12Q1/6886 , A61N5/10 , A61N2005/1087 , C12Q2600/156 , G01N33/57434 , G01N2800/50
摘要： Certain sequence variants have been found to be useful for correcting Prostate Specific Antigen levels in humans. The invention provides diagnostic applications based on such correction, including methods of diagnosis of prostate cancer.
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公开(公告)号：US20140087961A1
公开(公告)日：2014-03-27
申请号：US14004359
申请日：2012-03-16
申请人： Patrick Sulem , Julius Gudmundsson
发明人： Patrick Sulem , Julius Gudmundsson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： The invention discloses genetic variants that have been determined to be susceptibility variants of thyroid cancer. Methods of disease management, including methods of determining susceptibility to thyroid cancer, methods of predicting response to therapy and methods of predicting prognosis of thyroid cancer using such variants are described. The invention further relates to kits useful in the methods of the invention.
摘要翻译： 本发明公开了已被确定为甲状腺癌易感性变异体的遗传变异体。 描述了疾病管理方法，包括确定甲状腺癌易感性的方法，预测治疗反应的方法和使用这些变体预测甲状腺癌预后的方法。 本发明还涉及可用于本发明方法的试剂盒。
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5.发明申请Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition 失效CHR 11Q和6Q的遗传变异作为前列腺和结肠直肠癌易感性的标志物公开(公告)号：US20110053281A1
公开(公告)日：2011-03-03
申请号：US12315114
申请日：2008-11-26
IPC分类号： G01N33/50
CPC分类号： C12Q1/68 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G06F19/18 , G06F19/34 , G16H50/70 , Y02A90/26 , Y10T436/143333
摘要： It has been discovered that certain polymorphic markers on chromosome 6 and chromosome 11 are indicative of a susceptibility to prostate cancer and colon cancer. The invention describes diagnostic applications for determining a susceptibility to cancer using such markers, as well as kits for use in such applications.
摘要翻译： 已经发现，6号染色体和11号染色体上的某些多态性标记表示对前列腺癌和结肠癌的易感性。 本发明描述了使用这种标记物确定癌症易感性的诊断应用，以及用于此类应用的试剂盒。
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公开(公告)号：US20120150032A1
公开(公告)日：2012-06-14
申请号：US12966505
申请日：2010-12-13
IPC分类号： A61B8/00 , G06F19/00 , G01N33/573 , C12Q1/68 , C40B30/00
CPC分类号： C12Q1/6886 , A61N5/10 , A61N2005/1087 , C12Q2600/156 , G01N33/57434 , G01N2800/50
摘要： Certain sequence variants have been found to be useful for correcting Prostate Specific Antigen levels in humans. The invention provides diagnostic applications based on such correction, including methods of diagnosis of prostate cancer.
摘要翻译： 已经发现某些序列变体可用于校正人类中前列腺特异性抗原水平。 本发明提供了基于这种矫正的诊断应用，包括诊断前列腺癌的方法。
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公开(公告)号：US08865400B2
公开(公告)日：2014-10-21
申请号：US12442171
申请日：2008-02-07
申请人： Julius Gudmundsson , Patrick Sulem
发明人： Julius Gudmundsson , Patrick Sulem
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： The present invention is characterized by certain genetic variants being susceptibility variants for prostate cancer. The invention relates to methods of determining increased susceptibility to prostate cancer, as well as methods of determining decreased susceptibility to prostate cancer, using such variants. The invention further relates to kits for determining a susceptibility to prostate cancer.
摘要翻译： 本发明的特征在于某些遗传变体是前列腺癌的易感性变体。 本发明涉及确定对前列腺癌的易感性增加的方法，以及使用这些变体确定对前列腺癌易感性降低的方法。 本发明还涉及用于确定对前列腺癌易感性的试剂盒。
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公开(公告)号：US20110287946A1
公开(公告)日：2011-11-24
申请号：US13131597
申请日：2009-11-26
IPC分类号： C40B20/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/172
摘要： The invention discloses genetic variants that have been determined to be susceptibility variants of thyroid cancer. Methods of disease management, including methods of determining susceptibility to thyroid cancer, methods of predicting response to therapy and methods of predicting prognosis of thyroid cancer using such variants are described. The invention further relates to kits useful in the methods of the invention.
摘要翻译： 本发明公开了已被确定为甲状腺癌易感性变异体的遗传变异体。 描述了疾病管理方法，包括确定甲状腺癌易感性的方法，预测治疗反应的方法和使用这些变体预测甲状腺癌预后的方法。 本发明还涉及可用于本发明方法的试剂盒。
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公开(公告)号：US20110020320A1
公开(公告)日：2011-01-27
申请号：US12777113
申请日：2010-05-10
申请人： Julius Gudmundsson , Patrick Sulem
发明人： Julius Gudmundsson , Patrick Sulem
IPC分类号： A61K39/395 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G16B20/00
摘要： It has been discovered that certain genetic markers are associated with risk of prostate cancer. The invention describes diagnostic applications for determining a susceptibilty to prostate cancer using such markers, including methods, uses, kits, and computer applications.
摘要翻译： 已经发现某些遗传标记与前列腺癌的风险相关。 本发明描述了使用这种标记物确定前列腺癌易感性的诊断应用，包括方法，用途，试剂盒和计算机应用。
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10.发明授权Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition 失效CHR 11Q和6Q的遗传变异作为前列腺和结肠直肠癌易感性的标志物公开(公告)号：US08697360B2
公开(公告)日：2014-04-15
申请号：US12315114
申请日：2008-11-26
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G06F19/18 , G06F19/34 , G16H50/70 , Y02A90/26 , Y10T436/143333
摘要： It has been discovered that certain polymorphic markers on chromosome 6 and chromosome 11 are indicative of a susceptibility to prostate cancer and colon cancer. The invention describes diagnostic applications for determining a susceptibility to cancer using such markers, as well as kits for use in such applications.
摘要翻译： 已经发现，6号染色体和11号染色体上的某些多态性标记表示对前列腺癌和结肠癌的易感性。 本发明描述了使用这种标记物确定癌症易感性的诊断应用，以及用于此类应用的试剂盒。
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