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    MAGNETIC PARTICLE IMAGING DEVICES AND METHODS
    1.
    发明申请
    MAGNETIC PARTICLE IMAGING DEVICES AND METHODS 有权
    磁颗粒成像装置及方法

    公开(公告)号：US20110221438A1

    公开(公告)日：2011-09-15

    申请号：US13050779

    申请日：2011-03-17

    Applicant: Patrick W. Goodwill ,  Steven M. Conolly

    Inventor： Patrick W. Goodwill ,  Steven M. Conolly

    IPC: G01R33/00

    CPC classification number: A61B5/0515 ,  A61B5/7239 ,  A61B2576/00 ,  G01N27/72 ,  G01R33/10 ,  G01R33/1276

    Abstract: A magnetic particle imaging device is provided. The device includes a magnetic field source configured to produce a magnetic field having a non-saturating magnetic field region, an excitation signal source configured to produce an excitation signal in the non-saturating magnetic field region that produces a detectable signal from magnetic particles in the non-saturating magnetic field region, and a signal processor configured to convert a detected signal into an image of the magnetic particles. Aspects of the present disclosure also include methods of imaging magnetic particles in a sample, and methods of producing an image of magnetic particles in a subject. The subject devices and methods find use in a variety of applications, such as medical imaging applications.

    Abstract translation: 提供了一种磁粉成像装置。 该器件包括被配置为产生具有非饱和磁场区域的磁场的磁场源，激励信号源被配置为在非饱和磁场区域中产生激励信号，其产生来自磁饱和磁场区域中的磁性粒子的可检测信号 非饱和磁场区域和被配置为将检测到的信号转换成磁性颗粒的图像的信号处理器。 本公开的方面还包括在样品中成像磁性颗粒的方法以及在受试者中产生磁性颗粒的图像的方法。 主题装置和方法可用于各种应用，例如医学成像应用。

    Techniques for magnetic particle imaging
    2.
    发明授权
    Techniques for magnetic particle imaging 有权
    磁粉成像技术

    公开(公告)号：US08847592B2

    公开(公告)日：2014-09-30

    申请号：US12737214

    申请日：2009-06-23

    Applicant: Patrick W. Goodwill ,  Steven M. Conolly

    Inventor： Patrick W. Goodwill ,  Steven M. Conolly

    IPC: G01V3/00 ,  G01R33/02 ,  G01R33/12 ,  A61B5/05 ,  G01R33/10 ,  A61B5/00

    CPC classification number: G01N27/72 ,  A61B5/05 ,  A61B5/0515 ,  A61B5/7257 ,  G01R33/00 ,  G01R33/0213 ,  G01R33/10 ,  G01R33/1269 ,  G01R33/1276

    Abstract: A magnetic particle imaging apparatus includes magnets [106,107] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [102,114] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [112] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scanned to optimize scan time, scanning power, amplifier heating, SAR, dB/dt, and/or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.

    Abstract translation: 磁性粒子成像装置包括产生具有无场区域（FFR）的梯度磁场的磁体[106,107]，在无场区域内产生射频磁场的激励场电磁体[102,114]，高Q接收线圈[112 ]，其检测在无场区域中的磁性颗粒对激发场的响应。 场平移电磁铁产生均匀的磁场，使无场区域通过视场（FOV）移动，允许扫描成像区域以优化扫描时间，扫描功率，放大器加热，SAR，dB / dt和/或转换 率。 还提供了高效的多分辨率扫描技术。 处理互调低频和射频激励信号以产生成像区域内磁性纳米颗粒分布的图像。 使用不同谐波处的多个信号的去卷积来计算单个合成图像。

    IMPROVED TECHNIQUES FOR MAGNETIC PARTICLE IMAGING
    3.
    发明申请
    IMPROVED TECHNIQUES FOR MAGNETIC PARTICLE IMAGING 有权
    用于磁颗粒成像的改进技术

    公开(公告)号：US20110089942A1

    公开(公告)日：2011-04-21

    申请号：US12737214

    申请日：2009-06-23

    Applicant: Patrick W. Goodwill ,  Steven M. Conolly

    Inventor： Patrick W. Goodwill ,  Steven M. Conolly

    IPC: G01R33/12

    CPC classification number: G01N27/72 ,  A61B5/05 ,  A61B5/0515 ,  A61B5/7257 ,  G01R33/00 ,  G01R33/0213 ,  G01R33/10 ,  G01R33/1269 ,  G01R33/1276

    Abstract: A magnetic particle imaging apparatus includes magnets [106,107] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [102,114] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [112] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scanned to optimize scan time, scanning power, amplifier heating, SAR, dB/dt, and/or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.

    Abstract translation: 磁性粒子成像装置包括产生具有无场区域（FFR）的梯度磁场的磁体[106,107]，在无场区域内产生射频磁场的激励场电磁体[102,114]，高Q接收线圈[112 ]，其检测在无场区域中的磁性颗粒对激发场的响应。 场平移电磁铁产生均匀的磁场，使无场区域通过视场（FOV）移动，允许扫描成像区域以优化扫描时间，扫描功率，放大器加热，SAR，dB / dt和/或转换 率。 还提供了高效的多分辨率扫描技术。 处理互调低频和射频激励信号以产生成像区域内磁性纳米颗粒分布的图像。 使用不同谐波处的多个信号的去卷积来计算单个合成图像。

    Magnetic particle imaging devices and methods
    4.
    发明授权
    Magnetic particle imaging devices and methods 有权
    磁粉成像装置及方法

    公开(公告)号：US08884617B2

    公开(公告)日：2014-11-11

    申请号：US13050779

    申请日：2011-03-17

    Applicant: Patrick W. Goodwill ,  Steven M. Conolly

    Inventor： Patrick W. Goodwill ,  Steven M. Conolly

    IPC: G01V3/00

    CPC classification number: A61B5/0515 ,  A61B5/7239 ,  A61B2576/00 ,  G01N27/72 ,  G01R33/10 ,  G01R33/1276

    Abstract: A magnetic particle imaging device is provided. The device includes a magnetic field source configured to produce a magnetic field having a non-saturating magnetic field region, an excitation signal source configured to produce an excitation signal in the non-saturating magnetic field region that produces a detectable signal from magnetic particles in the non-saturating magnetic field region, and a signal processor configured to convert a detected signal into an image of the magnetic particles. Aspects of the present disclosure also include methods of imaging magnetic particles in a sample, and methods of producing an image of magnetic particles in a subject. The subject devices and methods find use in a variety of applications, such as medical imaging applications.

    Abstract translation: 提供了一种磁粉成像装置。 该器件包括被配置为产生具有非饱和磁场区域的磁场的磁场源，激励信号源被配置为在非饱和磁场区域中产生激励信号，其产生来自磁饱和磁场区域中的磁性粒子的可检测信号 非饱和磁场区域和被配置为将检测到的信号转换成磁性颗粒的图像的信号处理器。 本公开的方面还包括在样品中成像磁性颗粒的方法以及在受试者中产生磁性颗粒的图像的方法。 主题装置和方法可用于各种应用，例如医学成像应用。

    MAGNETIC PARTICLE IMAGING
    6.
    发明申请
    MAGNETIC PARTICLE IMAGING 审中-公开

    公开(公告)号：US20180017639A1

    公开(公告)日：2018-01-18

    申请号：US15648401

    申请日：2017-07-12

    Applicant: Patrick W. Goodwill

    Inventor： Patrick W. Goodwill

    IPC: G01R33/12 ,  A61B5/05

    CPC classification number: G01R33/1276 ,  A61B5/0515 ,  G01N27/72 ,  G01R33/0213 ,  G01R33/10

    Abstract: A Magnetic Particle Imaging (MPI) system with a magnet configured to generate a magnetic field with a field free line, the magnet integrated with a flux return designed so that a flux path at approximately the center of the field-free line has a first reluctance and a second flux path distal from the center of the field-free line has a second reluctance, and the second reluctance is lower than the first reluctance to facilitate a high fidelity magnetic field and high fidelity field free line.

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