公开(公告)号：US06346098B1

公开(公告)日：2002-02-12

申请号：US09519950

申请日：2000-03-07

申请人： Paul G. Yock ,  Ali H. Hassan ,  Alan Ching Yeun Yeung ,  Andrew Carter ,  Mehrdad Rezaee ,  Niall Herity ,  Sidney Lo ,  Peter J. Fitzgerald

发明人： Paul G. Yock ,  Ali H. Hassan ,  Alan Ching Yeun Yeung ,  Andrew Carter ,  Mehrdad Rezaee ,  Niall Herity ,  Sidney Lo ,  Peter J. Fitzgerald

IPC分类号： A61M2500

CPC分类号： A61K48/00 ,  A61K38/00 ,  A61M37/00

摘要： Methods are provided for locally administering an agent to a host. Specifically, the subject methods provide for the local administration of an agent to an interstitial space of a host. In the subject methods, an agent is retroinfused into a vessel of a host, typically a vein, under conditions sufficient for the agent to enter an interstitial space of the host proximal to the vessel location into which the agent is retroinfused. In practicing the subject methods, the agent is administered to the host in combination with the production of vascular stress at the site of administration, where the vascular tissue stress is sufficient to provide for transport of the agent from the vascular site of deposition into the target interstitial space. In a preferred embodiment, the agent is retroinfused at a pressure sufficient to provide for mechanical stress on the vessel proximal to the target interstitial space. Also provided are kits for use in practicing the subject methods. The subject invention finds use in the local administration of a variety of different agents for treatment of a variety of different disease or other conditions.

摘要翻译： 提供用于向宿主局部施用药剂的方法。 具体地，主题方法提供了代理人对主机的间隙空间的本地管理。 在本发明的方法中，在足以使试剂进入宿主的间隙空间的条件下，将试剂逆向灌注到宿主（通常为静脉）的血管中，所述间质空间靠近所述药剂被回输入其中的血管位置。 在实施本发明方法中，将药剂与给药部位的血管应激的产生相结合地施用于宿主，其中血管组织应激足以提供将药物从血管沉积部位输送到靶 间隙空间 在优选的实施方案中，所述试剂在足以在靠近所述靶间质空间的血管上提供机械应力的压力下进行回灌。 还提供了用于实践主题方法的套件。 本发明用于局部施用各种不同的药剂以治疗各种不同的疾病或其他病症。