公开(公告)号：US09157906B2

公开(公告)日：2015-10-13

申请号：US12951775

申请日：2010-11-22

申请人： Paul Greengard ,  David Repaske ,  Gretchen Snyder

发明人： Paul Greengard ,  David Repaske ,  Gretchen Snyder

IPC分类号： C12Q1/00 ,  G01N33/573 ,  G01N33/50 ,  C12Q1/44 ,  G01N33/94 ,  A61K31/00 ,  A61K31/137 ,  A61K31/55 ,  A61K49/00

CPC分类号： G01N33/5041 ,  A61K31/00 ,  A61K31/137 ,  A61K31/55 ,  A61K49/0008 ,  C12Q1/44 ,  G01N33/9413 ,  G01N2333/916 ,  G01N2500/04 ,  G01N2800/2835

摘要： The present invention provides methods and compositions for modulating the activity of phosphodiesterase 1B (PDE1B) in intracellular signaling pathways, including but not limited to, dopamine D1 intracellular signaling pathways. The invention also provides methods and compositions for modulating the activities of intracellular signaling molecules, including, but not limited to, DARPP-32 and GluR1 AMPA receptor, via modulation of PDE1B. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate PDE1B activity. The invention also provides methods of treating or ameliorating the symptoms of a disorder, including but not limited to a PDE1B-related disorder or a dopamine D1 receptor intracellular signaling pathway disorder, by administering a modulator of PDE1B, preferably, but not limited to, an inhibitor of PDE1B or an agent that decreases the production of PDE1B.

公开(公告)号：US20080176961A1

公开(公告)日：2008-07-24

申请号：US11801400

申请日：2007-05-08

申请人： Paul Greengard ,  David Repaske ,  Gretchen Snyder

发明人： Paul Greengard ,  David Repaske ,  Gretchen Snyder

IPC分类号： A61K35/00 ,  C12N5/06 ,  A61P25/16 ,  C12Q1/44

CPC分类号： G01N33/5041 ,  A61K31/00 ,  A61K31/137 ,  A61K31/55 ,  A61K49/0008 ,  C12Q1/44 ,  G01N33/9413 ,  G01N2333/916 ,  G01N2500/04 ,  G01N2800/2835

摘要： The present invention provides methods and compositions for modulating the activity of phosphodiesterase 1B (PDE1B) in intracellular signaling pathways, including but not limited to, dopamine D1 intracellular signaling pathways. The invention also provides methods and compositions for modulating the activities of intracellular signaling molecules, including, but not limited to, DARPP-32 and GluR1 AMPA receptor, via modulation of PDE1B. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate PDE1B activity. The invention also provides methods of treating or ameliorating the symptoms of a disorder, including but not limited to a PDE1B-related disorder or a dopamine D1 receptor intracellular signaling pathway disorder, by administering a modulator of PDE1B, preferably, but not limited to, an inhibitor of PDE1B or an agent that decreases the production of PDE1B.

摘要翻译： 本发明提供用于调节磷酸二酯酶1B（PDE1B）在细胞内信号传导途径中的活性的方法和组合物，包括但不限于多巴胺D1细胞内信号通路。 本发明还提供了通过PDE1B的调节来调节细胞内信号分子活性的方法和组合物，包括但不限于DARPP-32和GluR1 AMPA受体。 本发明还提供了用于筛选调节PDE1B活性的化合物的药物组合物和方法。 本发明还提供了通过施用PDE1B的调节剂来治疗或改善病症症状（包括但不限于PDE1B相关病症或多巴胺D1受体细胞内信号传导途径障碍）的方法，优选但不限于， PDE1B抑制剂或降低PDE1B生产的试剂。

公开(公告)号：US20130239234A1

公开(公告)日：2013-09-12

申请号：US12951775

申请日：2010-11-22

申请人： Paul Greengard ,  David Repaske ,  Gretchen Snyder

发明人： Paul Greengard ,  David Repaske ,  Gretchen Snyder

IPC分类号： G01N33/50 ,  A61K31/55 ,  A61K49/00

CPC分类号： G01N33/5041 ,  A61K31/00 ,  A61K31/137 ,  A61K31/55 ,  A61K49/0008 ,  C12Q1/44 ,  G01N33/9413 ,  G01N2333/916 ,  G01N2500/04 ,  G01N2800/2835

摘要： The present invention provides methods and compositions for modulating the activity of phosphodiesterase 1B (PDE1B) in intracellular signaling pathways, including but not limited to, dopamine D1 intracellular signaling pathways. The invention also provides methods and compositions for modulating the activities of intracellular signaling molecules, including, but not limited to, DARPP-32 and GluR1 AMPA receptor, via modulation of PDE1B. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate PDE1B activity. The invention also provides methods of treating or ameliorating the symptoms of a disorder, including but not limited to a PDE1B-related disorder or a dopamine D1 receptor intracellular signaling pathway disorder, by administering a modulator of PDE1B, preferably, but not limited to, an inhibitor of PDE1B or an agent that decreases the production of PDE1B.

摘要翻译： 本发明提供用于调节磷酸二酯酶1B（PDE1B）在细胞内信号传导途径中的活性的方法和组合物，包括但不限于多巴胺D1细胞内信号通路。 本发明还提供了通过PDE1B的调节来调节细胞内信号分子活性的方法和组合物，包括但不限于DARPP-32和GluR1 AMPA受体。 本发明还提供了用于筛选调节PDE1B活性的化合物的药物组合物和方法。 本发明还提供了通过施用PDE1B的调节剂来治疗或改善病症症状（包括但不限于PDE1B相关病症或多巴胺D1受体细胞内信号传导途径障碍）的方法，优选但不限于， PDE1B抑制剂或降低PDE1B生产的试剂。