公开(公告)号：US06358527B1

公开(公告)日：2002-03-19

申请号：US09585122

申请日：2000-06-01

申请人： Paul Marie Victor Gilis ,  Valentin Florent Victor De Condé

发明人： Paul Marie Victor Gilis ,  Valentin Florent Victor De Condé

IPC分类号： A61K920

CPC分类号： A61K9/2054 ,  A61K9/2018 ,  A61K9/2027 ,  A61K31/55 ,  Y10S514/813 ,  Y10S514/879 ,  Y10S514/96

摘要： The present invention is concerned with a fast-dissolving tablet for oral administration comprising as an active ingredient a therapeutically effective amount of galanthamine hydrobromide (1:1) and a pharmaceutically acceptable carrier, characterized in that said carrier comprises a spray dried mixture of lactose monohydrate and microcrystalline cellulose (75:25) as a diluent, and a disintegrant; and with a direct compression process of preparing such fast-dissolving tablets.

摘要翻译： 本发明涉及用于口服给药的快速溶解片剂，其包含治疗有效量的加兰他敏氢溴酸盐（1:1）和药学上可接受的载体作为活性成分，其特征在于所述载体包含喷雾干燥的乳糖一水合物 和微晶纤维素（75:25）作为稀释剂，和崩解剂; 并通过制备这种快速溶解片的直接压制方法。