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11 条记录 (耗时 0.012 秒)

    Bioadhesive solid dosage form
    2.
    发明授权
    Bioadhesive solid dosage form 失效
    生物粘合剂固体剂型

    公开(公告)号：US06303147B1

    公开(公告)日：2001-10-16

    申请号：US09091685

    申请日：1998-06-19

    申请人： Paul Marie Victor Gilis

    发明人： Paul Marie Victor Gilis

    IPC分类号： A61K902

    CPC分类号： A61K9/006 ,  A61K9/2013

    摘要： The present invention is concerned with bioadhesive pharmaceutical compositions comprising a pharmaceutically effective amount of an active ingredient, from 80% to 98.8% (w/w/) pre-gelatinized starch, and from 1% to 10% (w/w) of a hydrophilic matrix forming polymer, characterized in that the composition further comprises from 0.2% to 5% (w/w) alkaliC16-22alkyl fumarate as a lubricant; solid dosage forms such as tablets which are suitable for oral, nasal, rectal and vaginal administration; processes of preparing the compositions and solid dosage forms.

    摘要翻译： 本发明涉及生物粘附性药物组合物，其包含药学有效量的活性成分，80-98.8％（w / w）预胶化淀粉和1％至10％（w / w） 亲水性基质形成聚合物，其特征在于所述组合物还包含0.2％至5％（w / w）碱性C16-22烷基富马酸酯作为润滑剂; 固体剂型，例如适于口服，鼻，直肠和阴道给药的片剂; 制备组合物和固体剂型的方法。

    Fast-dissolving galanthamine hydrobromide tablet
    8.
    发明授权
    Fast-dissolving galanthamine hydrobromide tablet 有权
    快速溶解雪花胺氢溴酸盐片

    公开(公告)号：US06358527B1

    公开(公告)日：2002-03-19

    申请号：US09585122

    申请日：2000-06-01

    申请人： Paul Marie Victor Gilis ,  Valentin Florent Victor De Condé

    发明人： Paul Marie Victor Gilis ,  Valentin Florent Victor De Condé

    IPC分类号： A61K920

    CPC分类号： A61K9/2054 ,  A61K9/2018 ,  A61K9/2027 ,  A61K31/55 ,  Y10S514/813 ,  Y10S514/879 ,  Y10S514/96

    摘要： The present invention is concerned with a fast-dissolving tablet for oral administration comprising as an active ingredient a therapeutically effective amount of galanthamine hydrobromide (1:1) and a pharmaceutically acceptable carrier, characterized in that said carrier comprises a spray dried mixture of lactose monohydrate and microcrystalline cellulose (75:25) as a diluent, and a disintegrant; and with a direct compression process of preparing such fast-dissolving tablets.

    摘要翻译： 本发明涉及用于口服给药的快速溶解片剂，其包含治疗有效量的加兰他敏氢溴酸盐（1:1）和药学上可接受的载体作为活性成分，其特征在于所述载体包含喷雾干燥的乳糖一水合物 和微晶纤维素（75:25）作为稀释剂，和崩解剂; 并通过制备这种快速溶解片的直接压制方法。