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公开(公告)号:US09040050B2
公开(公告)日:2015-05-26
申请号:US12442808
申请日:2007-09-26
申请人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
发明人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
IPC分类号: A61K39/395 , C07K16/28 , A61K45/06 , A61K39/00
CPC分类号: C07K16/2896 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/34 , A61K2300/00
摘要: The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non-corticosteroid chemotherapeutic agent.
摘要翻译: 本发明涉及使用包含结合CD38的抗体,皮质类固醇和非皮质类固醇化学治疗剂的组合疗法治疗癌症的新方法。
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公开(公告)号:US20100092489A1
公开(公告)日:2010-04-15
申请号:US12442808
申请日:2007-09-26
申请人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
发明人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
IPC分类号: A61K39/395 , A61P35/00
CPC分类号: C07K16/2896 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/34 , A61K2300/00
摘要: The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non- corticosteroid chemotherapeutic agent.
摘要翻译: 本发明涉及使用包含结合CD38的抗体,皮质类固醇和非皮质类固醇化学治疗剂的组合疗法治疗癌症的新方法。
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公开(公告)号:US20130004480A1
公开(公告)日:2013-01-03
申请号:US12308836
申请日:2007-07-04
申请人: Paul Parren , Steen Lisby , Ole Baadsgaard
发明人: Paul Parren , Steen Lisby , Ole Baadsgaard
IPC分类号: A61K39/395 , A61P11/00
CPC分类号: C07K16/2887 , A61K2039/505 , C07K2317/21
摘要: Use of CD20 binding molecules, such as anti-CD20 antibodies, for the treatment of chronic obstructive pulmonary disease (COPD).
摘要翻译: 使用CD20结合分子,如抗CD20抗体,用于治疗慢性阻塞性肺疾病(COPD)。
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4.
公开(公告)号:US09428582B2
公开(公告)日:2016-08-30
申请号:US12306436
申请日:2007-07-03
申请人: Klaus Edvardsen , Steen Lisby , Ole Baadsgaard
发明人: Klaus Edvardsen , Steen Lisby , Ole Baadsgaard
IPC分类号: A61K31/495 , A61K39/395 , C07K16/28 , A61K45/06 , C07K16/24 , A61K39/00
CPC分类号: C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/507 , C07K16/244 , A61K2300/00
摘要: The invention relates to a method for the treatment of a disease susceptible to anti-EGFR treatment, comprising the step of administering, to a human being in nee thereof, a combination of an anti-EGFR agent and an anti-neutrophil-chemoattracta agent, wherein said anti-neutrophil-chemoattractant agent is administered in a dosage regimen that is sufficient to reduce one or more undesired dermatological side-effects the anti-EGFR agent. In one embodiment, the anti-EGFR agent is an anti-EGF antibody and the anti-neutrophil-chemoattractant agent is an anti-IL-8 antibody.
摘要翻译: 本发明涉及一种治疗易受抗EGFR治疗的疾病的方法,包括向其中的人施用抗EGFR药物和抗中性粒细胞 - 化学吸收剂的组合的步骤, 其中所述抗嗜中性粒细胞趋化剂以足以减少抗EGFR药物的一种或多种非期望的皮肤病学副作用的剂量方案给药。 在一个实施方案中,抗EGFR剂为抗EGF抗体,抗中性粒细胞趋化剂为抗IL-8抗体。
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公开(公告)号:US20100150936A1
公开(公告)日:2010-06-17
申请号:US12306436
申请日:2007-07-03
申请人: Klaus Edvardsen , Steen Lisby , Ole Baadsgaard
发明人: Klaus Edvardsen , Steen Lisby , Ole Baadsgaard
IPC分类号: A61K39/395 , A61P37/06
CPC分类号: C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/507 , C07K16/244 , A61K2300/00
摘要: The invention relates to a method for the treatment of a disease susceptible to anti-EGFR treatment, comprising the step of administering, to a human being in nee thereof, a combination of an anti-EGFR agent and an anti-neutrophil-chemoattracta agent, wherein said anti-neutrophil-chemoattractant agent is administered in a dosage regimen that is sufficient to reduce one or more undesired dermatological side-effects the anti-EGFR agent. In one embodiment, the anti-EGFR agent is an anti-EGF antibody and the anti-neutrophil-chemoattractant agent is an anti-IL-8 antibody.
摘要翻译: 本发明涉及一种治疗易受抗EGFR治疗的疾病的方法,包括向其中的人施用抗EGFR药物和抗中性粒细胞 - 化学吸收剂的组合的步骤, 其中所述抗嗜中性粒细胞趋化剂以足以减少抗EGFR药物的一种或多种非期望的皮肤病学副作用的剂量方案给药。 在一个实施方案中,抗EGFR剂为抗EGF抗体,抗中性粒细胞趋化剂为抗IL-8抗体。
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公开(公告)号:US20130171148A1
公开(公告)日:2013-07-04
申请号:US13700246
申请日:2011-05-27
申请人: Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
发明人: Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
IPC分类号: C07K16/30
CPC分类号: C07K16/30 , A61K2039/505 , C07K16/32 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/472
摘要: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
摘要翻译: 公开了与人表皮生长因子受体2(HER2)结合的分离的单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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公开(公告)号:US07282568B2
公开(公告)日:2007-10-16
申请号:US10738120
申请日:2003-12-16
申请人: Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jørgen Petersen
发明人: Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jørgen Petersen
IPC分类号: A61K39/395
CPC分类号: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
摘要: Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译: 公开了与IL-8结合的分离的人单克隆抗体(例如人IL-8)。 人抗体可以通过进行V-D-J重组和同种型转换,在能够产生人单克隆抗体多重同种型的杂交瘤,转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体,非人转基因动物,杂交瘤和产生人抗体的转染瘤的药物组合物,以及使用人抗体的治疗和诊断方法。
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公开(公告)号:US09714294B2
公开(公告)日:2017-07-25
申请号:US13700246
申请日:2011-05-27
申请人: Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
发明人: Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
IPC分类号: C07K16/30 , A61K39/395 , C07K16/32 , A61K39/00
CPC分类号: C07K16/30 , A61K2039/505 , C07K16/32 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/472
摘要: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号:US20080118517A1
公开(公告)日:2008-05-22
申请号:US11823481
申请日:2007-06-27
申请人: Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
发明人: Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
IPC分类号: A61K39/395 , C07K16/24
CPC分类号: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
摘要: Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译: 公开了与IL-8结合的分离的人单克隆抗体(例如人IL-8)。 人抗体可以通过进行V-D-J重组和同种型转换,在能够产生人单克隆抗体多重同种型的杂交瘤,转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体,非人转基因动物,杂交瘤和产生人抗体的转染瘤的药物组合物,以及使用人抗体的治疗和诊断方法。
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10.
公开(公告)号:US09150658B2
公开(公告)日:2015-10-06
申请号:US13133811
申请日:2009-12-09
申请人: Sandra Verploegen , David P. E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
发明人: Sandra Verploegen , David P. E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
IPC分类号: C07K16/36 , A61K39/395
CPC分类号: C07K16/36 , A61K39/395 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要: Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
摘要翻译: 公开了结合人TF和相关的基于抗体的组合物和分子的分离的人单克隆抗体。 还公开了包含抗体的药物组合物,以及使用抗体的治疗和诊断方法。
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