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公开(公告)号:US09040050B2
公开(公告)日:2015-05-26
申请号:US12442808
申请日:2007-09-26
申请人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
发明人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
IPC分类号: A61K39/395 , C07K16/28 , A61K45/06 , A61K39/00
CPC分类号: C07K16/2896 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/34 , A61K2300/00
摘要: The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non-corticosteroid chemotherapeutic agent.
摘要翻译: 本发明涉及使用包含结合CD38的抗体,皮质类固醇和非皮质类固醇化学治疗剂的组合疗法治疗癌症的新方法。
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公开(公告)号:US20100092489A1
公开(公告)日:2010-04-15
申请号:US12442808
申请日:2007-09-26
申请人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
发明人: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
IPC分类号: A61K39/395 , A61P35/00
CPC分类号: C07K16/2896 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/34 , A61K2300/00
摘要: The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non- corticosteroid chemotherapeutic agent.
摘要翻译: 本发明涉及使用包含结合CD38的抗体,皮质类固醇和非皮质类固醇化学治疗剂的组合疗法治疗癌症的新方法。
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公开(公告)号:US20090148449A1
公开(公告)日:2009-06-11
申请号:US11886932
申请日:2006-03-23
申请人: Michel De Weers , Yvo Graus , Judith Oprins , Paul Parren , Jan Van De Winkel , Martine Van Vugt
发明人: Michel De Weers , Yvo Graus , Judith Oprins , Paul Parren , Jan Van De Winkel , Martine Van Vugt
IPC分类号: A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06 , G01N33/574 , A61K31/7088 , C12N1/21 , A01K67/027 , A01H5/00
CPC分类号: C07K16/40 , A61K39/3955 , A61K45/06 , A61K49/0004 , A61K2039/505 , C07K14/70596 , C07K16/2896 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/566 , G01N2333/70596
摘要: Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译: 公开了与人CD38结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含人抗体的药物组合物,以及使用人抗体的治疗和诊断方法。
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公开(公告)号:US07829673B2
公开(公告)日:2010-11-09
申请号:US11886932
申请日:2006-03-23
申请人: Michel De Weers , Yvo Graus , Judith Oprins , Paul Parren , Jan Van De Winkel , Martine Van Vugt
发明人: Michel De Weers , Yvo Graus , Judith Oprins , Paul Parren , Jan Van De Winkel , Martine Van Vugt
CPC分类号: C07K16/40 , A61K39/3955 , A61K45/06 , A61K49/0004 , A61K2039/505 , C07K14/70596 , C07K16/2896 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/566 , G01N2333/70596
摘要: Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译: 公开了与人CD38结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含人抗体的药物组合物,以及使用人抗体的治疗和诊断方法。
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公开(公告)号:US20090076249A1
公开(公告)日:2009-03-19
申请号:US11901953
申请日:2007-09-19
申请人: Michel De Weers , Yvo Graus , Judith Oprins , Paul Parren , Jan Van De Winkel , Martine Van Vugt
发明人: Michel De Weers , Yvo Graus , Judith Oprins , Paul Parren , Jan Van De Winkel , Martine Van Vugt
IPC分类号: C07K16/18
CPC分类号: C07K16/2896 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/92
摘要: Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译: 公开了与人CD38结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含人抗体的药物组合物,以及使用人抗体的治疗和诊断方法。
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公开(公告)号:US09187565B2
公开(公告)日:2015-11-17
申请号:US12886930
申请日:2010-09-21
申请人: Michel De Weers , Yvo Graus , Judith Oprins , Paul Parren , Jan Van De Winkel , Martine Van Vugt
发明人: Michel De Weers , Yvo Graus , Judith Oprins , Paul Parren , Jan Van De Winkel , Martine Van Vugt
IPC分类号: A61K38/00 , C07K16/28 , C07K14/705 , A61K39/00
CPC分类号: C07K16/40 , A61K39/3955 , A61K45/06 , A61K49/0004 , A61K2039/505 , C07K14/70596 , C07K16/2896 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/566 , G01N2333/70596
摘要: Isolated human monoclonal antibodies which bind to human CD38, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号:US20130209355A1
公开(公告)日:2013-08-15
申请号:US13702857
申请日:2011-06-08
申请人: Michel De Weers , Tim Walseth , Jan Van De Winkel , Tom Vink , Paul Parren
发明人: Michel De Weers , Tim Walseth , Jan Van De Winkel , Tom Vink , Paul Parren
IPC分类号: C07K16/28 , A61K45/06 , A61K39/395
CPC分类号: C07K16/2878 , A61K39/3955 , A61K45/06 , C07K16/2896 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/76 , G01N33/573 , G01N2333/91148
摘要: Isolated monoclonal antibodies which bind to human CD38 and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies.
摘要翻译: 公开了结合人CD38和相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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