公开(公告)号：US07122027B2

公开(公告)日：2006-10-17

申请号：US10155296

申请日：2002-05-23

申请人： Paul V. Trescony ,  Kenneth E. Rohly ,  James R. Keogh ,  Darrell F. Untereker ,  Naim S. Istephanous

发明人： Paul V. Trescony ,  Kenneth E. Rohly ,  James R. Keogh ,  Darrell F. Untereker ,  Naim S. Istephanous

IPC分类号： A61M37/00

CPC分类号： A61K9/0024 ,  A61K9/0009 ,  A61K33/00 ,  A61K33/40

摘要： The present invention generally relates to medical devices. Specifically, the invention pertains to implantable medical devices that produces gaseous agents from precursors and releases them into the body. More specifically, the invention provides for the controlled release of the gaseous agent to the body to produce a local or systemic therapeutic effect.

公开(公告)号：US20120123338A1

公开(公告)日：2012-05-17

申请号：US13387071

申请日：2011-06-16

申请人： Jeffrey P. Rouleau ,  Kenneth E. Rohly ,  Timothy J. Denison

发明人： Jeffrey P. Rouleau ,  Kenneth E. Rohly ,  Timothy J. Denison

IPC分类号： A61M5/142

CPC分类号： A61M5/14244 ,  A61M2005/14264 ,  A61M2205/332 ,  A61M2205/3368 ,  A61M2230/63

摘要： The invention relates to systems and methods for stabilizing therapeutic formulations used in medical devices. In particular, the invention relates to systems designed to inhibit the aggregation of therapeutic molecules such as polypeptides stored within a medication delivery device, for example polypeptide aggregation that can result from jostling the medication within a fluid medication reservoir. In embodiments of the invention, a damping system is operably connected to a fluid medication reservoir that is disposed within the housing of a device so as to inhibit the agitation of a fluid medication. Typically the damping system comprises one or more energy absorbing materials.

摘要翻译： 本发明涉及用于稳定医疗器械中使用的治疗剂型的系统和方法。 特别地，本发明涉及被设计用于抑制治疗分子（例如存储在药物递送装置内的多肽）的聚集的系统，例如可能由于在流体药物储存器内推挤药物而导致的多肽聚集。 在本发明的实施例中，阻尼系统可操作地连接到设置在装置的壳体内的流体药物储存器，以便抑制流体药物的搅动。 通常，阻尼系统包括一种或多种能量吸收材料。