公开(公告)号：US20050187176A1

公开(公告)日：2005-08-25

申请号：US10961479

申请日：2004-10-08

申请人： Paula Bates ,  Allicia Girvan ,  Shirish Barve

发明人： Paula Bates ,  Allicia Girvan ,  Shirish Barve

IPC分类号： A61K48/00 ,  C12N15/115 ,  G01N33/50

CPC分类号： C12N15/115 ,  A61K48/00 ,  C12N2310/16 ,  C12N2310/18

摘要： Methods of treating inflammation in a patient comprise administering to the patient a composition comprising a GRO.

摘要翻译： 治疗患者炎症的方法包括向患者施用包含GRO的组合物。

公开(公告)号：US20050164942A1

公开(公告)日：2005-07-28

申请号：US11085919

申请日：2005-03-22

申请人： Peter Oeltgen ,  Paul Bishop ,  Craig McClain ,  Shirish Barve

发明人： Peter Oeltgen ,  Paul Bishop ,  Craig McClain ,  Shirish Barve

IPC分类号： A61K38/10

CPC分类号： A61K38/10 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  Y10S514/893 ,  Y10S514/894 ,  Y10S514/937

摘要： A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.

公开(公告)号：US06875742B2

公开(公告)日：2005-04-05

申请号：US09971902

申请日：2001-10-05

申请人： Peter R. Oeltgen ,  Paul D. Bishop ,  Craig J. McClain ,  Shirish Barve

发明人： Peter R. Oeltgen ,  Paul D. Bishop ,  Craig J. McClain ,  Shirish Barve

IPC分类号： A61K38/10 ,  C07K14/435

CPC分类号： A61K38/10 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  Y10S514/893 ,  Y10S514/894 ,  Y10S514/937

摘要： A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.

摘要翻译： 通过向哺乳动物施用化合物D SEQ ID NO：1来调节细胞因子介导的肝损伤的方法。 在生理上可接受的制剂中，化合物浓度在约0.5mg / kg至约20mg / kg的范围内阻断细胞因子级联。 因此公开了调节细胞因子介导的急性炎症，创伤诱导和毒素诱导的肝损伤的治疗方法，特别是通过肿瘤坏死因子调节。

公开(公告)号：US07335642B2

公开(公告)日：2008-02-26

申请号：US11085919

申请日：2005-03-22

申请人： Peter R. Oeltgen ,  Paul D. Bishop ,  Craig J. McClain ,  Shirish Barve

发明人： Peter R. Oeltgen ,  Paul D. Bishop ,  Craig J. McClain ,  Shirish Barve

IPC分类号： A61K38/10 ,  C07K14/435

CPC分类号： A61K38/10 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  Y10S514/893 ,  Y10S514/894 ,  Y10S514/937

摘要： A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.

摘要翻译： 通过向哺乳动物施用化合物D SEQ ID NO：1来调节细胞因子介导的肝损伤的方法。 在生理上可接受的制剂中，化合物浓度在约0.5mg / kg至约20mg / kg的范围内阻断细胞因子级联。 因此公开了调节细胞因子介导的急性炎症，创伤诱导和毒素诱导的肝损伤的治疗方法，特别是通过肿瘤坏死因子调节。

公开(公告)号：US06380164B1

公开(公告)日：2002-04-30

申请号：US09767657

申请日：2001-01-23

申请人： Peter R. Oeltgen ,  Craig J. McClain ,  Shirish Barve ,  Paul D. Bishop

发明人： Peter R. Oeltgen ,  Craig J. McClain ,  Shirish Barve ,  Paul D. Bishop

IPC分类号： A61K3808

CPC分类号： A61K38/08 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  Y10S514/893 ,  Y10S514/894 ,  Y10S514/937

摘要： A method of modulating cytokine mediated hepatic injury by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, deltorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade in a murine model of septic shock. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.

摘要翻译： 通过向哺乳动物施用deltorphins来调节细胞因子介导的肝损伤的方法。 Deltorphin I SEQ ID NO：1，deltorphin II SEQ ID NO：2或deltorphins I SEQ ID NO：1和II SEQ ID NO：2的组合可以施用。 在生理上可接受的制剂中，约0.5mg / kg至约20mg / kg范围内的delphphin浓度阻断脓毒性休克鼠模型中的细胞因子级联。 因此公开了调节细胞因子介导的急性炎症，创伤诱导和毒素诱导的肝损伤的治疗方法，特别是通过肿瘤坏死因子调节。