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公开(公告)号：US06875742B2
公开(公告)日：2005-04-05
申请号：US09971902
申请日：2001-10-05
IPC分类号： A61K38/10 , C07K14/435
CPC分类号： A61K38/10 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y10S514/893 , Y10S514/894 , Y10S514/937
摘要： A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
摘要翻译： 通过向哺乳动物施用化合物D SEQ ID NO：1来调节细胞因子介导的肝损伤的方法。 在生理上可接受的制剂中，化合物浓度在约0.5mg / kg至约20mg / kg的范围内阻断细胞因子级联。 因此公开了调节细胞因子介导的急性炎症，创伤诱导和毒素诱导的肝损伤的治疗方法，特别是通过肿瘤坏死因子调节。
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2.发明授权Method for treating a viral infection related or a chemical toxin related hepatic injury with deltorphin D 失效用deltorphin D治疗病毒感染或化学毒素相关肝损伤的方法公开(公告)号：US07335642B2
公开(公告)日：2008-02-26
申请号：US11085919
申请日：2005-03-22
IPC分类号： A61K38/10 , C07K14/435
CPC分类号： A61K38/10 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y10S514/893 , Y10S514/894 , Y10S514/937
摘要： A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
摘要翻译： 通过向哺乳动物施用化合物D SEQ ID NO：1来调节细胞因子介导的肝损伤的方法。 在生理上可接受的制剂中，化合物浓度在约0.5mg / kg至约20mg / kg的范围内阻断细胞因子级联。 因此公开了调节细胞因子介导的急性炎症，创伤诱导和毒素诱导的肝损伤的治疗方法，特别是通过肿瘤坏死因子调节。
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公开(公告)号：US06380164B1
公开(公告)日：2002-04-30
申请号：US09767657
申请日：2001-01-23
IPC分类号： A61K3808
CPC分类号： A61K38/08 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y10S514/893 , Y10S514/894 , Y10S514/937
摘要： A method of modulating cytokine mediated hepatic injury by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, deltorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade in a murine model of septic shock. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
摘要翻译： 通过向哺乳动物施用deltorphins来调节细胞因子介导的肝损伤的方法。 Deltorphin I SEQ ID NO：1，deltorphin II SEQ ID NO：2或deltorphins I SEQ ID NO：1和II SEQ ID NO：2的组合可以施用。 在生理上可接受的制剂中，约0.5mg / kg至约20mg / kg范围内的delphphin浓度阻断脓毒性休克鼠模型中的细胞因子级联。 因此公开了调节细胞因子介导的急性炎症，创伤诱导和毒素诱导的肝损伤的治疗方法，特别是通过肿瘤坏死因子调节。
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公开(公告)号：US06645938B2
公开(公告)日：2003-11-11
申请号：US09757860
申请日：2001-01-10
IPC分类号： A61K3800
摘要： A compound and method for using compound-D SEQ ID NO:1 to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
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公开(公告)号：US06316411B1
公开(公告)日：2001-11-13
申请号：US09477100
申请日：2000-01-04
IPC分类号： A61K3800
摘要： A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
摘要翻译： 使用该化合物以减少与哺乳动物器官如心脏的缺血和再灌注相关的损伤的化合物和方法。 该化合物可以作为预处理策略的一部分施用，其减少损伤的程度并且在停止和恢复血流之后改善器官功能。 该化合物可用于准备计划的缺血或以预防方式预期进一步的缺血事件。
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公开(公告)号：US06294519B1
公开(公告)日：2001-09-25
申请号：US09702305
申请日：2000-10-31
申请人： Peter R. Oeltgen , Mark S. Kindy , Paul D. Bishop
发明人： Peter R. Oeltgen , Mark S. Kindy , Paul D. Bishop
IPC分类号： A01N3718
摘要： A method for treating ischemia by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, delntorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration of about 0.5-20 mg/kg body weight, or alternatively a lower concentration of about 1-1000 &mgr;g/kg body weight of the mammal in a physiologically acceptable formulation is administered up to four hours after an ischemic episode. Deltorphins may also be administered prior to or concurrently with onset of ischemia. Cerebral or spinal cord ischemia or ischemic heart disease may be treated using the method of the invention.
摘要翻译： 一种通过向哺乳动物施用去铁蛋白来治疗缺血的方法。 可以给予Deltorphin I SEQ ID NO：1，delntorphin II SEQ ID NO：2或deltorphins I SEQ ID NO：1和II SEQ ID NO：2的组合。 在缺血发作后4小时内给药约0.5-20mg / kg体重的滴度，或者在生理上可接受的制剂中哺乳动物的约1-1000μg/ kg体重的较低浓度。 去头痛也可以在缺血发作之前或同时发生。 可以使用本发明的方法治疗脑或脊髓缺血或缺血性心脏病。
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公开(公告)号：US07060792B2
公开(公告)日：2006-06-13
申请号：US11141670
申请日：2005-05-31
IPC分类号： A61K38/00
摘要： A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound, either Deltorphin A and/or Dermorphin H, may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
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公开(公告)号：US06900178B2
公开(公告)日：2005-05-31
申请号：US09947656
申请日：2001-09-06
摘要： A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound, either Deltorphin A and/or Dermorphin H, may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
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公开(公告)号：US07208578B2
公开(公告)日：2007-04-24
申请号：US11133823
申请日：2005-05-20
IPC分类号： C07K14/00
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to polynucleotide and polypeptide molecules for zacrp2, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. The polypeptides and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp2 polypeptides.
摘要翻译： 本发明涉及用于zacrp2的多核苷酸和多肽分子，其是具有胶原样结构域和C1q结构域的蛋白家族的新成员。 编码它们的多肽和多核苷酸参与二聚化或低聚反应，并可用于其研究。 本发明还包括针对zacrp2多肽的抗体。
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公开(公告)号：US07179787B2
公开(公告)日：2007-02-20
申请号：US10990246
申请日：2004-11-16
申请人： Paul O. Sheppard , Paul D. Bishop
发明人： Paul O. Sheppard , Paul D. Bishop
CPC分类号： C07K14/52 , A61K38/00 , C07K14/4702 , C07K2319/00 , C12Q1/6888 , C12Q2600/158
摘要： The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1–3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
摘要翻译： 本发明提供新的用途，称为“Zven”的新家族人类蛋白质的两个成员，作为刺激胃肠收缩力，胃排空，肠道运输和治疗胃轻瘫的药物。位于人染色体3p21.1中的Zven1基因 -3p14.3，表达于睾丸组织和外周血淋巴细胞。
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