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1.发明授权Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics 失效对免疫球蛋白E特异性的核酸配体及其作为特应性疾病治疗剂的用途公开(公告)号：US07579450B2
公开(公告)日：2009-08-25
申请号：US11115780
申请日：2005-04-26
申请人： Paula Burmeister , Sharon Cload , John L. Diener , Anthony Dominic Keefe , Sara Chesworth Keene , Markus Kurz , H. A. Daniel Lagassé , Harold Nicholas Marsh , Pooja Sawhney , Chunhua Wang
发明人： Paula Burmeister , Sharon Cload , John L. Diener , Anthony Dominic Keefe , Sara Chesworth Keene , Markus Kurz , H. A. Daniel Lagassé , Harold Nicholas Marsh , Pooja Sawhney , Chunhua Wang
IPC分类号： C07H21/04
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/331 , C12N2310/336 , C12N2310/351 , C12N2310/3521
摘要： The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.
摘要翻译： 本发明公开了能够结合免疫球蛋白E（“IgE”）的适体，其可用作特应性疾病和/或其中涉及IgE的其它疾病或病症的治疗剂和诊断。 本发明还涉及用于施用能够结合IgE的适体的材料和方法。
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2.发明授权Materials and methods for the generation of transcripts comprising modified nucleotides 有权用于产生包含修饰的核苷酸的转录物的材料和方法公开(公告)号：US08101385B2
公开(公告)日：2012-01-24
申请号：US12004626
申请日：2007-12-21
CPC分类号： C12N9/1247 , C12P19/34
摘要： Materials and methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence.
摘要翻译： 提供材料和方法用于产生具有掺入其序列的修饰的三磷酸核苷酸的适体治疗剂。
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3.发明申请Materials and methods for the generation of transcripts comprising modified nucleotides 有权用于产生包含修饰的核苷酸的转录物的材料和方法公开(公告)号：US20100120024A1
公开(公告)日：2010-05-13
申请号：US12004626
申请日：2007-12-21
CPC分类号： C12N9/1247 , C12P19/34
摘要： Materials and Methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence.
摘要翻译： 提供材料和方法用于产生具有掺入其序列的修饰的三磷酸核苷酸的适体治疗剂。
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4.发明授权Materials and methods for the generation of fully 2′-modified nucleic acid transcripts 有权用于产生完全2'-修饰的核酸转录物的材料和方法公开(公告)号：US08105813B2
公开(公告)日：2012-01-31
申请号：US11480188
申请日：2006-06-30
IPC分类号： C12N9/12
CPC分类号： C12N15/1048 , C12N9/1247 , C12N15/115 , C12N2310/16 , C12N2310/321 , C12N2330/30 , C12Q1/6846 , C12Q1/6865 , G01N2333/9125 , C12Q2525/117 , C12Q2521/119 , C12N2310/3521
摘要： Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.
摘要翻译： 提供材料和方法用于产生具有并入其序列的完全修饰的三磷酸核苷酸的适体治疗剂。
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公开(公告)号：US20090081679A1
公开(公告)日：2009-03-26
申请号：US12220327
申请日：2008-07-21
IPC分类号： C12Q1/68
CPC分类号： C12N15/1048
摘要： The invention describes methods for the in vivo selection of oligonucleotides, preferably aptamers, that persist in biological compartments. In one embodiment, the biological compartment comprises at least one tissue which, in a preferred embodiment, is the blood within the circulatory system of a living mammal. The invention also contemplates oligonucleotides, preferably aptamers, selected through in vivo SELEX that may be linked to therapeutic or diagnostic compositions including other oligonucleotides.
摘要翻译： 本发明描述了用于体内选择存在于生物室中的寡核苷酸，优选适体的方法。 在一个实施方案中，生物室包含至少一个组织，其在优选的实施方案中是活的哺乳动物的循环系统内的血液。 本发明还考虑通过体内SELEX选择的寡核苷酸，优选适配体，其可以与包括其它寡核苷酸的治疗或诊断组合物连接。
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公开(公告)号：US20080214489A1
公开(公告)日：2008-09-04
申请号：US12075696
申请日：2008-03-12
IPC分类号： A61K31/70
CPC分类号： C12N15/1135 , A61K2039/5256 , C12N15/111 , C12N15/1137 , C12N15/1138 , C12N15/87 , C12N2310/14 , C12N2310/16 , C12N2310/315 , C12N2310/317 , C12N2310/322 , C12N2310/332 , C12N2310/3519 , C12N2320/32 , C12Y207/11013
摘要： Compositions and methods to mediate the intracellular and sub-cellular delivery of therapeutic, diagnostic and imaging agents, such as oligonucleotides. The compositions of the invention include nucleic acid conjugates comprising a delivery aptamer that is connected to an oligonucleotide. The delivery aptamer may be connected directly to the oligonucleotide, or may be connected indirectly to the oligonucleotide, such as through a linker. The oligonucleotide may be either a therapeutic, diagnostic or imaging oligonucleotide. The methods of the invention are used to increase potency, or alter distribution, half-life, metabolic fate, toxicity and other characteristics.
摘要翻译： 介导治疗，诊断和显像剂如寡核苷酸的细胞内和亚细胞递送的组合物和方法。 本发明的组合物包括包含与寡核苷酸连接的递送适体的核酸缀合物。 递送适体可以直接连接到寡核苷酸，或者可以间接连接到寡核苷酸，例如通过接头。 寡核苷酸可以是治疗性的，诊断性的或成像的寡核苷酸。 本发明的方法用于增加效力或改变分布，半衰期，代谢命运，毒性等特征。
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