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1.APTAMER THERAPEUTICS USEFUL IN THE TREATMENT OF COMPLEMENT-RELATED DISORDERS 有权
标题翻译: APTAMER治疗有效治疗补充相关疾病公开(公告)号:US20120322860A1
公开(公告)日:2012-12-20
申请号:US13525680
申请日:2012-06-18
申请人: CLAUDE BENEDICT , DAVID EPSTEIN , CHARLES WILSON , DILARA MCCAULEY , JEFFREY KURZ , MARKUS KURZ , THOMAS GREENE MCCAULEY , JAMES ROTTMAN
发明人: CLAUDE BENEDICT , DAVID EPSTEIN , CHARLES WILSON , DILARA MCCAULEY , JEFFREY KURZ , MARKUS KURZ , THOMAS GREENE MCCAULEY , JAMES ROTTMAN
CPC分类号: C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
摘要翻译: 本发明提供了使用这些核酸治疗剂治疗补体相关疾病的核酸治疗剂和方法。
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公开(公告)号:US07790421B2
公开(公告)日:2010-09-07
申请号:US11483495
申请日:2006-07-10
申请人: Markus Kurz , Peter Lohse , Richard W. Wagner
发明人: Markus Kurz , Peter Lohse , Richard W. Wagner
IPC分类号: C12P19/34
CPC分类号: C12P19/34 , C07K1/1077 , C07K17/02 , C12N15/1006 , C12N15/1062 , C12N15/1075 , C12N15/11
摘要: Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products.
摘要翻译: 本文描述了用于将肽受体与RNA连接的方法和试剂,以及RNA-肽受体产物。
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3.Multivalent aptamer therapeutics with improved pharmacodynamic properties and methods of making and using the same 审中-公开
标题翻译: 具有改善的药效学性质的多价适体治疗剂及其制备和使用方法公开(公告)号:US20070009476A1
公开(公告)日:2007-01-11
申请号:US11482671
申请日:2006-07-06
申请人: Charles Wilson , David Epstein , Jeffrey Kurz , Markus Kurz
发明人: Charles Wilson , David Epstein , Jeffrey Kurz , Markus Kurz
IPC分类号: A61K38/22 , A61K31/785 , C08G63/91
CPC分类号: C12N15/115 , C07H21/04 , C12N2310/16 , C12N2310/3183
摘要: Materials and methods are provided for producing aptamer therapeutics having improved pharmacokinetic and pharmacodymanic properties, as well as increased target valency. The aptamers produced by the methods of the invention are useful as therapeutics for treating disease.
摘要翻译: 提供材料和方法用于生产具有改善的药代动力学和药效学性质的适配剂治疗剂以及提高的目标化合价。 通过本发明的方法产生的适体可用作治疗疾病的治疗剂。
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公开(公告)号:US20060018871A1
公开(公告)日:2006-01-26
申请号:US11058134
申请日:2005-02-14
申请人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
发明人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
CPC分类号: C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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5.Aptamer therapeutics useful in the treatment of complement-related disorders 有权
标题翻译: 适用于治疗补体相关疾病的适体药物公开(公告)号:US07803931B2
公开(公告)日:2010-09-28
申请号:US11058134
申请日:2005-02-14
申请人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Chesworth Keene , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna J. Zoltoski
发明人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Chesworth Keene , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna J. Zoltoski
IPC分类号: C07H21/04
CPC分类号: C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
摘要翻译: 本发明提供了使用这些核酸治疗剂治疗补体相关疾病的核酸治疗剂和方法。
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公开(公告)号:US07538211B2
公开(公告)日:2009-05-26
申请号:US11318227
申请日:2005-12-22
申请人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Chesworth Keene , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna J. Zoltoski
发明人: Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Chesworth Keene , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna J. Zoltoski
IPC分类号: C07H21/04 , G01N33/551
CPC分类号: C12N15/115 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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公开(公告)号:US20070066551A1
公开(公告)日:2007-03-22
申请号:US11222466
申请日:2005-09-07
申请人: Anthony Keefe , Charles Wilson , John Diener , Markus Kurz
发明人: Anthony Keefe , Charles Wilson , John Diener , Markus Kurz
CPC分类号: C12N15/115 , C12N15/111 , C12N2310/16 , C12N2310/313 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/331 , C12N2310/333 , C12N2310/3341 , C12N2310/335 , C12N2310/336 , C12N2310/351 , C12N2320/13 , C12N2330/30 , C12N2310/3521
摘要: The invention relates generally to the field of nucleic acids and more particularly to aptamers useful as therapeutics, diagnostics and in research such as for target validation. The invention further relates to materials and methods for enhancing aptamers for use in therapeutics, diagnostics and research.
摘要翻译: 本发明一般涉及核酸领域,更具体地涉及可用作治疗,诊断和研究的适体,例如用于目标验证。 本发明还涉及用于增强用于治疗,诊断和研究的适体的材料和方法。
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8.Aptamer therapeutics useful in the treatment of complement-related disorders 有权
标题翻译: 适用于治疗补体相关疾病的适体药物公开(公告)号:US20070048248A1
公开(公告)日:2007-03-01
申请号:US11354657
申请日:2006-02-14
申请人: Claude Benedict , David Epstein , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Charles Wilson
发明人: Claude Benedict , David Epstein , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Charles Wilson
IPC分类号: A61K48/00
CPC分类号: C12N15/115 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
摘要翻译: 本发明提供了使用这些核酸治疗剂治疗补体相关疾病的核酸治疗剂和方法。
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9.Controlled modulation of the pharmacokinetics and biodistribution of aptamer therapeutics 审中-公开
标题翻译: 受体调节适体药物的药代动力学和生物分布公开(公告)号:US20060030535A1
公开(公告)日:2006-02-09
申请号:US11075648
申请日:2005-03-07
申请人: Judith Healy , Markus Kurz , Thomas McCauley , Kristin Thompson , Charles Wilson , Dorothy Margolskee
发明人: Judith Healy , Markus Kurz , Thomas McCauley , Kristin Thompson , Charles Wilson , Dorothy Margolskee
CPC分类号: C12N15/115 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2320/50 , C12N2310/3521
摘要: Materials and methods are provided to modulate, in a controlled manner, the pharmacokinetic and biodistribution properties of nucleic acid aptamers, and to enhance their safety and efficacy properties as therapeutic agents.
摘要翻译: 提供材料和方法以受控的方式调节核酸适配体的药代动力学和生物分布性质,并且增强其作为治疗剂的安全性和功效性质。
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公开(公告)号:US06416950B1
公开(公告)日:2002-07-09
申请号:US09453190
申请日:1999-12-02
申请人: Peter Lohse , Markus Kurz
发明人: Peter Lohse , Markus Kurz
IPC分类号: C12Q168
CPC分类号: C12N15/1096 , C07B2200/11 , C07H19/20 , C07H21/00 , C07K14/00 , C12N15/1062 , C12N15/1075 , C40B30/04 , C40B40/00 , C40B40/08 , C40B40/10 , C40B50/14
摘要: Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.
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