公开(公告)号：US07045124B1

公开(公告)日：2006-05-16

申请号：US09480260

申请日：2000-01-11

申请人： Pavel Hamet ,  Johannes Tremblay ,  Christine Desrosier ,  Huifang Chen

发明人： Pavel Hamet ,  Johannes Tremblay ,  Christine Desrosier ,  Huifang Chen

IPC分类号： A01N63/00

CPC分类号： A61M1/3681 ,  A61M1/32 ,  A61M1/3683 ,  A61M1/3687 ,  A61M1/369 ,  A61M2202/0216 ,  A61M2205/053 ,  A61N2005/0661

摘要： Apoptosis and/or necrosis related disorders in the mammalian body, namely radiation exposure disorders, chemical exposure and ingestion disorders, neurological disorders and physical trauma disorders, are treated, and their onset is counteracted by preconditioning, by extracting from the mammalian body an aliquot of blood, subjecting the extracted aliquot, ex vivo, to an oxidative stressor such as exposure to ozone gas, a temperature stressor, i.e. temperatures above or below body temperatures, and ultraviolet light, and re-injecting the treated blood aliquot into the mammalian body. The treatment ha the effect of decreasing apoptosis/necrosis in the body, and of pre-conditioning the body better to withstand subsequently encountered apoptosis-inducing events.

摘要翻译： 治疗哺乳动物体内的细胞凋亡和/或坏死相关疾病，即放射线暴露障碍，化学暴露和摄取障碍，神经系统疾病和身体创伤障碍，并通过预处理抵消其发作，通过从哺乳动物体内提取等分试样 血液，将提取的等分试样离体处理到氧化应激源，例如暴露于臭氧气体，温度应激器，即高于或低于体温的温度和紫外线，并将经处理的血液等分试样重新注射到哺乳动物体内。 这种治疗方法是减少身体凋亡/坏死的作用，并且更好地预处理身体，以抵御随后遇到的凋亡诱导事件。