公开(公告)号：US20210308358A1

公开(公告)日：2021-10-07

申请号：US17352596

申请日：2021-06-21

Applicant: PENUMBRA, INC.

Inventor： Karthik Raman ,  Colin Yee ,  Chia-Hung Sze ,  Arthur John Lockhart ,  David Barry

IPC: A61M1/36 ,  B01J39/04 ,  B01J39/26

Abstract: Doxorubicin is extracted from blood using anionic material, such as a resin comprising sulfonated polystyrene divinylbenzene beads, and polyethersulfone membrane, or both. After exposing the resin and/or membrane to blood in order to remove doxorubicin therefrom, the doxorubicin maybe extracted from the resin and/or membrane by exposing the material to an extraction solution, sonicating the extraction solution to enhance release of the doxorubicin, and repeating the exposure and sonication in order to remove substantially all of doxorubicin from the resin.

公开(公告)号：US11071812B2

公开(公告)日：2021-07-27

申请号：US15608023

申请日：2017-05-30

Applicant: Penumbra, Inc.

Inventor： Karthik Raman ,  Colin Yee ,  Chia-Hung Sze ,  Arthur John Lockhart ,  David Barry

IPC: A61M1/36 ,  B01J39/26 ,  B01J39/04

Abstract: Doxorubicin is extracted from blood using anionic material, such as a resin comprising sulfonated polystyrene divinylbenzene beads, and polyethersulfone membrane, or both. After exposing the resin and/or membrane to blood in order to remove doxorubicin therefrom, the doxorubicin maybe extracted from the resin and/or membrane by exposing the material to an extraction solution, sonicating the extraction solution to enhance release of the doxorubicin, and repeating the exposure and sonication in order to remove substantially all of doxorubicin from the resin.

公开(公告)号：US20170340797A1

公开(公告)日：2017-11-30

申请号：US15608023

申请日：2017-05-30

Applicant: Penumbra, Inc.

Inventor： Karthik Raman ,  Colin Yee ,  Chia-Hung Sze ,  Arthur John Lockhart ,  David Barry

IPC: A61M1/36 ,  A61M25/10 ,  A61F2/01 ,  B01J39/26 ,  B01J39/04

CPC classification number: A61M1/3615 ,  A61M1/3679 ,  B01J39/04 ,  B01J39/26

Abstract: Doxorubicin is extracted from blood using anionic material, such as a resin comprising sulfonated polystyrene divinylbenzene beads, and polyethersulfone membrane, or both. After exposing the resin and/or membrane to blood in order to remove doxorubicin therefrom, the doxorubicin maybe extracted from the resin and/or membrane by exposing the material to an extraction solution, sonicating the extraction solution to enhance release of the doxorubicin, and repeating the exposure and sonication in order to remove substantially all of doxorubicin from the resin.