公开(公告)号：US08021883B2

公开(公告)日：2011-09-20

申请号：US11912172

申请日：2006-05-11

Applicant: Per Strøman

Inventor： Per Strøman

IPC: C12N15/01

CPC classification number: A23C9/1234 ,  A23L29/065 ,  A23L33/135 ,  A61K35/745 ,  C12N1/20 ,  C12N15/01 ,  C12R1/01

Abstract: Many probiotic Bifidobacteriacea contains an active tetW that renders the cells resistant to tetracycline. This may present a risk of a horizontal transfer of functional antibiotic genes. The present invention relates to a method of obtaining novel tetracycline-sensitive strains of the genus of Bifidobacteriacea (Bifidobacterium sp.). In particular, the present invention relates to novel antibiotic-sensitive strains obtained from antibiotic-resistant probiotic strains and the use of such novel strains for the preparation of a food or feed product or a dosage form comprising viable organisms.

Abstract translation: 许多益生菌双歧杆菌含有使细胞对四环素具有抗性的活性tetW。 这可能会导致功能性抗生素基因水平转移的风险。 本发明涉及获得双歧杆菌属（双歧杆菌属）新型四环素敏感菌株的方法。 特别地，本发明涉及由抗生素抗性益生菌菌株获得的新型抗生素敏感菌株，以及这种新型菌株用于制备食品或饲料产品或包含活生物体的剂型的用途。

公开(公告)号：US08440450B2

公开(公告)日：2013-05-14

申请号：US13233507

申请日：2011-09-15

Applicant: Per Strøman

Inventor： Per Strøman

IPC: C12N1/21

CPC classification number: A23C9/1234 ,  A23L29/065 ,  A23L33/135 ,  A61K35/745 ,  C12N1/20 ,  C12N15/01 ,  C12R1/01

Abstract: Many probiotic Bifidobacteriaceacontains an active tetW that renders the cells resistant to tetracycline. This may present a risk of a horizontal transfer of functional antibiotic genes. The present invention relates to a method of obtaining novel tetracycline-sensitive strains of the genus of Bifidobacteriacea (Bifidobacterium sp.). In particular, the present invention relates to novel antibiotic-sensitive strains obtained from antibiotic-resistant probiotic strains and the use of such novel strains for the preparation of a food or feed product or a dosage form comprising viable organisms.

Abstract translation: 许多益生菌双歧杆菌具有使细胞对四环素具有抗性的活性tetW。 这可能会导致功能性抗生素基因水平转移的风险。 本发明涉及获得双歧杆菌属（双歧杆菌属）新型四环素敏感菌株的方法。 特别地，本发明涉及由抗生素抗性益生菌菌株获得的新型抗生素敏感菌株，以及这种新型菌株用于制备食品或饲料产品或包含活生物体的剂型的用途。