公开(公告)号：US20190249197A1

公开(公告)日：2019-08-15

申请号：US16399919

申请日：2019-04-30

申请人： MD HEALTHCARE INC.

发明人： Yoon-Keun KIM

IPC分类号： C12N15/88 ,  C12R1/01 ,  A61K9/127 ,  C12Q1/686 ,  C12Q1/6886 ,  C12Q1/06

CPC分类号： C12N15/88 ,  A61K9/1271 ,  C12Q1/06 ,  C12Q1/686 ,  C12Q1/6886 ,  C12R1/01

摘要： The present invention relates to vesicles derived from genus Morganella bacteria and a use thereof, the present inventors experimentally confirmed that the vesicles were significantly decreased in clinical samples derived from patients with a malignant disease such as gastric cancer, colorectal cancer, pancreatic cancer, bile duct cancer, breast cancer, ovarian cancer, bladder cancer, prostate cancer and lymphoma, a cardiovascular disease such as myocardial infarction, cardiomyopathy, atrial fibrillation, variant angina, and stroke, diabetes mellitus, and Parkinson's disease as compared to normal persons, and the vesicles suppressed the secretion of inflammatory mediators by pathogenic vesicles and suppressed the occurrence of cancer, so that the vesicles derived from genus Morganella bacteria may be usefully used for the purpose of developing a method for diagnosing a malignant disease such as gastric cancer, colorectal cancer, pancreatic cancer, bile duct cancer, breast cancer, ovarian cancer, bladder cancer, prostate cancer and lymphoma, a cardiovascular disease such as myocardial infarction, cardiomyopathy, atrial fibrillation, variant angina, and stroke, diabetes mellitus, and Parkinson's disease, and a composition for preventing or treating the diseases or an inflammatory disease

公开(公告)号：US20190216864A1

公开(公告)日：2019-07-18

申请号：US16368655

申请日：2019-03-28

申请人： PROBIOTICAL S.P.A.

发明人： Giovanni MOGNA ,  Gian Paolo STROZZI ,  Luca MOGNA

IPC分类号： A61K35/745 ,  A23L33/135 ,  C12R1/01

CPC分类号： A61K35/745 ,  A23L33/135 ,  A61K35/74 ,  C12R1/01 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/481

摘要： Selection of probiotic strains belonging to the genus Bifidobacterium and to a symbiotic composition containing the same for use of feeding infants, is described.

公开(公告)号：US20190192584A1

公开(公告)日：2019-06-27

申请号：US16290581

申请日：2019-03-01

申请人： KIRIN HOLDINGS KABUSHIKI KAISHA

发明人： Daisuke FUJIWARA ,  Kenta Jonai ,  Tetsu Sugimura

IPC分类号： A61K35/744 ,  A23L33/135 ,  A23C19/032 ,  A23C9/123 ,  G01N33/68 ,  A61K35/747 ,  A61K31/711 ,  C12Q1/6809 ,  C12N15/74 ,  A23C19/06 ,  C12R1/01 ,  A61K9/00 ,  C12N1/20

CPC分类号： A61K35/744 ,  A23C9/123 ,  A23C9/1236 ,  A23C19/0323 ,  A23C19/062 ,  A23L33/135 ,  A23Y2240/41 ,  A61K9/0053 ,  A61K31/711 ,  A61K35/747 ,  C12N1/20 ,  C12N15/746 ,  C12Q1/6809 ,  C12R1/01 ,  G01N33/6866

摘要： This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp. lactis JCM20101, Leuconostoc lactis NBRC12455, Leuconostoc lactis NRIC1540, Pediococcus damnosus JCM5886, or Streptococcus thermophilus TA-45.

公开(公告)号：US20190183943A1

公开(公告)日：2019-06-20

申请号：US16329186

申请日：2017-06-09

申请人： COENBIO CO., LTD.

发明人： Kyu Jin YUM

IPC分类号： A61K35/744 ,  A23L33/135 ,  A61Q7/00 ,  A61K9/00 ,  A61K8/99 ,  A61K35/747 ,  A61K35/745 ,  A61P3/06 ,  A61P15/10 ,  C12R1/01 ,  A61P17/14

CPC分类号： A61K35/744 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/35 ,  A23Y2260/35 ,  A61K8/99 ,  A61K9/00 ,  A61K9/0029 ,  A61K9/0053 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K2035/115 ,  A61P3/06 ,  A61P15/10 ,  A61P17/14 ,  A61Q7/00 ,  C12N1/20 ,  C12R1/01

摘要： The present invention relates to a novel Leuconostoc holzapfelii Ceb-kc-003 (deposited as Korea Accession Number accession KCCM11830P) strain and a composition comprising the same. The novel strain has abilities of preventing hair loss, promoting hair growth, or improving sexual function.

公开(公告)号：US20180303963A1

公开(公告)日：2018-10-25

申请号：US16021570

申请日：2018-06-28

申请人： Hyundai Motor Company

发明人： So Yoon Park ,  Tae Hee Lee ,  Ji Wan Kim ,  Ki Young Yoon

IPC分类号： A61L9/01 ,  B01D53/84 ,  C12N1/20

CPC分类号： A61L9/01 ,  B01D53/84 ,  B01D2251/95 ,  B01D2257/91 ,  B60H3/00 ,  C12N1/20 ,  C12R1/01 ,  F25B39/02 ,  Y02A50/2358

摘要： Disclosed is a coating composition for preventing odor. The coating composition may include one or more types of odorless microorganisms selected from the group consisting of Caulobacter vibrioides, Bradyrhizobium diazoefficiens, Bradyrhizobium daqingense and Methylobacterium brachiatum or a culture solution thereof. Further provided is a method for preventing odor, and the method may include applying the coating composition for preventing odor. When a biofilm is formed from the microorganisms in the coating composition by coating an object on which an odor-causing microorganism can live, the inflow and the inhabitation of external microorganisms generating odor may be significantly blocked, thereby enabling odor to be effectively prevented.

公开(公告)号：US20180282825A1

公开(公告)日：2018-10-04

申请号：US15936661

申请日：2018-03-27

申请人： Alimentary Health Ltd.

发明人： Liam O'MAHONY ,  Barry KIELY ,  John Francis CRYAN ,  Timothy DINAN ,  Eileen Frances MURPHY

IPC分类号： C12R1/01 ,  A23L33/135 ,  C12N1/20 ,  A23G9/36 ,  A23C9/123 ,  A61K35/745

CPC分类号： C12R1/01 ,  A23C9/1234 ,  A23G9/363 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2300/55 ,  A61K35/745 ,  C12N1/20 ,  Y02A50/473 ,  A23V2200/3204 ,  A23V2200/324

摘要： Probiotic Bifidobacterium strain AH1714 is significantly immunomodulatory following oral consumption. The strain is useful as an immunomodulatory biotherapeutic agent.

公开(公告)号：US20180274036A1

公开(公告)日：2018-09-27

申请号：US15756845

申请日：2016-09-02

申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER

发明人： Marcel Van Den Brink ,  Robert Jenq ,  Jonathan U. Peled

IPC分类号： C12Q1/6886 ,  A23L33/135 ,  A61K35/741 ,  A61K9/00 ,  A61P35/00 ,  A61K38/16 ,  A61K45/06

CPC分类号： C12Q1/6886 ,  A23L33/135 ,  A23V2002/00 ,  A61K9/0031 ,  A61K9/0043 ,  A61K9/0053 ,  A61K35/28 ,  A61K35/74 ,  A61K35/741 ,  A61K38/164 ,  A61K45/06 ,  A61P35/00 ,  C12N1/20 ,  C12Q1/689 ,  C12Q2600/158 ,  C12R1/01

摘要： The present invention relates to methods and compositions for reducing the risk of cancer relapse in a subject who has received cancer treatment. It is based, at least in part, on the discovery that a restricted fraction of the gut microbiota, including the bacteria Streptococcus anginosus, Parvimonas micra, Acidaminococcus intestini, Eubacterium limosum, Clostridium glycyrrhizinilyticum, Desulfosporosinus lacus, Eubacterium biforme, Anaerofustis stercorihominis, Pseudoramibacter alactolyticus, Peptococcus niger, Armatimonas rosea, Saccharofermentans acetigenes, Finegoldia magna, Levyella massiliensis, Gallicola barnesae, Murdochiella asaccharolytica, and Eubacterium brachy are associated with a reduced risk of cancer relapse.

公开(公告)号：US20180249716A1

公开(公告)日：2018-09-06

申请号：US15829844

申请日：2017-12-01

申请人： Indigo Ag, Inc.

发明人： Raymond Riley

IPC分类号： A01N63/04 ,  C12N1/14 ,  C12N15/82 ,  A01H3/00 ,  A01H5/02 ,  A01H5/04 ,  A01H5/06 ,  A01H5/10 ,  A01C1/06

CPC分类号： A01N63/04 ,  A01C1/06 ,  A01H3/00 ,  A01H5/02 ,  A01H5/04 ,  A01H5/06 ,  A01H5/10 ,  A01H17/00 ,  A01N63/00 ,  C12N1/14 ,  C12N1/20 ,  C12N15/8261 ,  C12Q1/689 ,  C12Q1/6895 ,  C12R1/01 ,  C12R1/645 ,  C12R1/66

摘要： This invention relates to methods and materials for modulating the characteristics of a plant, said plant having been heterologously disposed to an endophyte or a plurality of endophytes, or derived from a plant reproductive element heterologously disposed to an endophyte or a plurality of endophytes.

公开(公告)号：US10059968B2

公开(公告)日：2018-08-28

申请号：US15314227

申请日：2015-05-28

申请人： Reliance Industries Limited

发明人： Gautam Das ,  Santanu Dasgupta ,  Venkatesh Prasad ,  Vinodhkumar Vijayakumar ,  Pranali Deore ,  Kannadasan Kaliyamoorthy ,  Sujata Kumari

IPC分类号： C12N1/12 ,  C12N15/82 ,  C12P7/64 ,  C12N15/10 ,  C11C3/00 ,  C12P7/00

CPC分类号： C12P7/6463 ,  C11C3/00 ,  C12N1/12 ,  C12N9/1007 ,  C12N9/1029 ,  C12N15/102 ,  C12N15/65 ,  C12N15/74 ,  C12P7/00 ,  C12R1/01 ,  C12Y201/01037 ,  C12Y203/01031

摘要： The present disclosure relates to a method for increasing lipid content in microorganisms. The method comprises decreasing the expression of molecules involved in the protein synthesis to decrease protein synthesis and thereby increase lipid synthesis in the microorganisms. The present disclosure also provides a modified microorganism having increased lipid content.

公开(公告)号：US10058574B2

公开(公告)日：2018-08-28

申请号：US15592178

申请日：2017-05-10

申请人： 4D Pharma Research Limited

发明人： George Grant ,  Angela Margaret Patterson ,  Imke Mulder ,  Seanin McCluskey ,  Emma Raftis

IPC分类号： A01N63/00 ,  A61K35/74 ,  C12R1/01 ,  A23L33/135 ,  A23C9/12 ,  A61K9/19 ,  A61K39/02 ,  A61K39/00

CPC分类号： A61K35/74 ,  A23C9/12 ,  A23L33/135 ,  A23V2002/00 ,  A61K9/19 ,  A61K39/0216 ,  A61K2039/52 ,  A61K2039/545 ,  A61K2039/58 ,  C12R1/01

摘要： The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.