公开(公告)号：US06468563B1

公开(公告)日：2002-10-22

申请号：US09581684

申请日：2000-08-28

申请人： Peter C. Schmidt ,  Karin Rocksloh ,  Wolfgang Müller ,  Markus Reher ,  Salah Abu Abed

发明人： Peter C. Schmidt ,  Karin Rocksloh ,  Wolfgang Müller ,  Markus Reher ,  Salah Abu Abed

IPC分类号： A61K3578

CPC分类号： A61K9/2077

摘要： A process for producing rapidly disintegrating pharmaceutical formulations containing an extract is provided. The process comprises providing a dry powdered extract and a lubricant, compacting the powdered extract with the lubricant, using between about 0.5-10% lubricant by weight. The compacting is done using a device that yields flakes. The flakes are then crushed into granules, and the granules are compressed with conventional excipients such as bulking agents, glidants, disintegrants, flow regulators and other additives into pharmaceutical formulations.

摘要翻译： 提供了一种生产含有提取物的快速崩解药物制剂的方法。 该方法包括提供干粉末提取物和润滑剂，使用约0.5-10重量％的润滑剂，用润滑剂压实粉末状提取物。 压实使用产生薄片的装置完成。 然后将薄片粉碎成颗粒，并将颗粒用常规赋形剂如填充剂，助流剂，崩解剂，流动调节剂和其它添加剂压制成药物制剂。