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    Method and device for producing pharmaceutical formulations containing an extract
    2.
    发明授权
    Method and device for producing pharmaceutical formulations containing an extract 失效
    用于制备含有提取物的药物制剂的方法和装置

    公开(公告)号：US06468563B1

    公开(公告)日：2002-10-22

    申请号：US09581684

    申请日：2000-08-28

    申请人： Peter C. Schmidt ,  Karin Rocksloh ,  Wolfgang Müller ,  Markus Reher ,  Salah Abu Abed

    发明人： Peter C. Schmidt ,  Karin Rocksloh ,  Wolfgang Müller ,  Markus Reher ,  Salah Abu Abed

    IPC分类号： A61K3578

    CPC分类号： A61K9/2077

    摘要： A process for producing rapidly disintegrating pharmaceutical formulations containing an extract is provided. The process comprises providing a dry powdered extract and a lubricant, compacting the powdered extract with the lubricant, using between about 0.5-10% lubricant by weight. The compacting is done using a device that yields flakes. The flakes are then crushed into granules, and the granules are compressed with conventional excipients such as bulking agents, glidants, disintegrants, flow regulators and other additives into pharmaceutical formulations.

    摘要翻译： 提供了一种生产含有提取物的快速崩解药物制剂的方法。 该方法包括提供干粉末提取物和润滑剂，使用约0.5-10重量％的润滑剂，用润滑剂压实粉末状提取物。 压实使用产生薄片的装置完成。 然后将薄片粉碎成颗粒，并将颗粒用常规赋形剂如填充剂，助流剂，崩解剂，流动调节剂和其它添加剂压制成药物制剂。

    Pharmaceutical preparation with an active substance of low solubility in water and gastric juices
    4.
    发明授权
    Pharmaceutical preparation with an active substance of low solubility in water and gastric juices 失效
    具有在水和胃液中溶解度低的活性物质的药物制剂

    公开(公告)号：US4727109A

    公开(公告)日：1988-02-23

    申请号：US814483

    申请日：1985-12-30

    申请人： Peter C. Schmidt ,  Bernd Stockebrand ,  Gerhard Fischer

    发明人： Peter C. Schmidt ,  Bernd Stockebrand ,  Gerhard Fischer

    IPC分类号： A61K9/48 ,  A61K9/66 ,  A61K9/00

    CPC分类号： A61K9/4866 ,  A61K9/4858

    摘要： A pharmaceutical preparation having an active substance of low solubility in water and gastric juices that has an initially liquid carrier system consisting of a hydrophilic component, a hydrophobic component and a solubilizer. The solvent mixture contains 9 to 90 parts by weight of solubilizer and 90 to 5 parts by weight of a hydropholic component, such as polyethylene glykol, 1,2-propylene glykol, 1,3-butanediol, 1,4-butanediol, 1,2-propanediol, glycerol, mannitol, sorbitol or polyoxyethylene polyoxypropylene copolymerisate or mixtures of such substances, and 40 to 1 parts by weight of an oleophilic component, such as natural and/or semisynthetic vegetable or animal oils or synthetic oils, such as neutral oil or waxes. The active substance is dissolved in the carrier system or dispersed in a stable way and for an oral application, is filled into drug capsules made of gelatine. In order to achieve a delayed release of the active substance (delayed-action effect), an adjuvant that is soluble in the carrier system is also added to the carrier system in the amount of up to 10 parts by weight, preferably 2 to 5 parts by weight that, after the dissolving of the capsule wall, develops in contact with the gastric juices a renewing permeable membrane. Suitable adjuvants are ethylcellulose, cellulose acetate phthalate, hydroxypropylmethylcellulose phthalate and vinylacetate crotonic acid copolymers or mixtures thereof.

    摘要翻译： 一种具有在水中溶解度低的活性物质和胃液的药物制剂，其具有由亲水组分，疏水组分和增溶剂组成的初始液体载体体系。 溶剂混合物含有9至90重量份的增溶剂和90至5重量份的疏水性组分，例如聚乙二醇，1,2-丙二醇，1,3-丁二醇，1,4-丁二醇， 2-丙二醇，甘油，甘露糖醇，山梨糖醇或聚氧乙烯聚氧丙烯共聚物或这些物质的混合物，以及40至1重量份的亲油组分，例如天然和/或半合成植物油或动物油或合成油，例如中性油 或蜡。 将活性物质溶解在载体体系中或以稳定的方式分散并作为口服应用，将其填充到由明胶制成的药物胶囊中。 为了实现活性物质的延迟释放（延迟作用效果），也可以在载体体系中添加可溶于载体体系的佐剂，其量最多为10重量份，优选为2至5重量份 ，使得在胶囊壁溶解之后，与胃液接触形成更新的渗透膜。 合适的佐剂是乙基纤维素，邻苯二甲酸乙酸纤维素酯，邻苯二甲酸羟丙基甲基纤维素和乙酸乙烯酯巴豆酸共聚物或其混合物。

    Separation of reacted hydrocarbons and catalyst in fluidized catalytic cracking
    5.
    发明授权
    Separation of reacted hydrocarbons and catalyst in fluidized catalytic cracking 失效
    反应的烃和催化剂在流化催化裂化中的分离

    公开(公告)号：US4721603A

    公开(公告)日：1988-01-26

    申请号：US689956

    申请日：1985-01-09

    申请人： Russell R. Krug ,  Peter C. Schmidt

    发明人： Russell R. Krug ,  Peter C. Schmidt

    IPC分类号： B01J8/00 ,  C10G11/18 ,  B01J8/18

    CPC分类号： B01J8/005 ,  C10G11/18

    摘要： A specific baffle arrangement within a catalytic reactor improves separation of gaseous hydrocarbon reaction products from catalyst within the reactor vessel of a fluidized catalytic cracker unit. The catalytic reactor vessel includes an outer generally cylindrical shell having a stripping zone arranged at the lower end of the vessel. An inlet riser conduit forming a primary reaction zone extends generally within the shell from the lower end of the vessel to a location near the top of the vessel. A shroud surrounds the upper end of the riser conduit and forms an annular outlet for downwardly discharging a mixtrue of hydrocarbon and catalyst. An annular catalyst disengaging riser baffle for deflecting the mixture from the outlet toward the wall of the vessel is arranged on the outside of the riser conduit below the annular outlet and above the stripping zone. Still further, an annular catalyst disengaging wall baffle is arranged on the inside of the shell for again deflecting the mixture, now mostly catalyst, generally downwardly and toward the stripping zone of the vessel. Preferably, the riser baffle and the wall baffle are arrnaged within the shell such that the baffles in concert with the annular discharge outlet form a partial cyclone separating zone between the baffles to thereby improve the separation of hydrocarbon vapors from the catalyst. This cyclone action promotes early disengagement of hydrocarbon vapor from the catalyst and reduces undesirable catalyst carryover in the vapor to conventional cyclones through which the hydrocarbon products are recovered. At the same time, undesirable secondary cracking reactions in the dilute phase are minimized by lowering the concentration of spent catalyst in the dilute phase.

    摘要翻译： 催化反应器内的特定的挡板装置改善气态烃反应产物与流化催化裂化装置的反应器容器内的催化剂的分离。 催化反应器容器包括外部大致圆柱形的外壳，其具有布置在容器下端的剥离区。 形成初级反应区的入口提升管通常在壳体内从容器的下端延伸到靠近容器顶部的位置。 护罩围绕提升管道的上端并形成用于向下排出烃和催化剂混合物的环形出口。 将环形催化剂脱离提升管挡板用于将混合物从出口朝向容器的壁偏转设置在提升管道的外部，在环形出口下方和汽提区域之上。 此外，环形催化剂分离壁挡板布置在壳体的内部，用于再次使混合物（现在主要是催化剂）大体向下并且朝向容器的汽提区域偏转。 优选地，提升板挡板和壁挡板在壳体内被布置，使得与环形排出口一致的挡板在挡板之间形成部分旋风分离区，从而改进烃蒸气与催化剂的分离。 这种旋风作用促进了烃蒸气从催化剂的早期脱离，并减少了蒸气中不期望的催化剂在常规旋流器中的滞留，通过这些旋风分离器回收烃产物。 同时，通过降低稀释相中废催化剂的浓度，使稀相中不期望的二次裂化反应最小化。

    Separation of reacted hydrocarbons and catalyst in fluidized catalytic cracking
    6.
    发明授权
    Separation of reacted hydrocarbons and catalyst in fluidized catalytic cracking 失效
    反应的烃和催化剂在流化催化裂化中的分离

    公开(公告)号：US4500423A

    公开(公告)日：1985-02-19

    申请号：US503781

    申请日：1983-06-13

    申请人： Russell R. Krug ,  Peter C. Schmidt

    发明人： Russell R. Krug ,  Peter C. Schmidt

    IPC分类号： B01J8/00 ,  C10G11/18

    CPC分类号： C10G11/18 ,  B01J8/005

    摘要： The present invention relates to a baffle arrangement that improves separation of gaseous hydrocarbon reaction products from catalyst within the reactor vessel of a fluidized catalytic cracker unit. The catalytic reactor vessel includes an outer generally cylindrical shell having a stripping zone arranged at the lower end of the vessel. An inlet riser conduit forming a primary reaction zone extends generally within the shell from the lower end of the vessel to a location near the top of the vessel. A shroud surrounds the upper end of the riser conduit and forms an annular outlet for downwardly discharging a mixture of hydrocarbon and catalyst. According to the present invention, an annular catalyst disengaging riser baffle for deflecting the mixture from the outlet toward the wall of the vessel is arranged on the outside of the riser conduit below the annular outlet and above the stripping zone. Still further, in the preferred embodiment an annular catalyst disengaging wall baffle is arranged on the inside of the shell for again deflecting the mixture, now mostly catalyst, generally downwardly and toward the stripping zone of the vessel. Preferably, the riser baffle and the wall baffle are arranged within the shell such that the baffles in concert with the annular discharge outlet form a partial cyclone separating zone. This cyclone action promotes early disengagement of hydrocarbon vapor from the catalyst and reduces undesirable catalyst carryover in the vapor to conventional cyclones through which the hydrocarbon products are recovered.

    摘要翻译： 本发明涉及一种改进气态烃反应产物与流化催化裂化装置的反应容器内的催化剂分离的挡板装置。 催化反应器容器包括外部大致圆柱形的外壳，其具有布置在容器下端的剥离区。 形成初级反应区的入口提升管通常在壳体内从容器的下端延伸到靠近容器顶部的位置。 护罩围绕提升管道的上端并形成用于向下排出烃和催化剂混合物的环形出口。 根据本发明，在环形出口下方和汽提区上方的提升管道的外侧设置有用于将混合物从出口向容器的壁偏转的环形催化剂分离提升管挡板。 此外，在优选实施例中，环形催化剂分离壁挡板布置在壳体的内部，用于再次使混合物（现在主要是催化剂）大体向下并且朝向容器的汽提区域偏转。 优选地，提升板挡板和壁挡板布置在壳体内，使得与环形排出口一致的挡板形成部分旋风分离区。 这种旋风作用促进了烃蒸气从催化剂的早期脱离，并减少了蒸气中不期望的催化剂在常规旋流器中的滞留，通过这些旋风分离器回收烃产物。