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    Water guns
    1.
    发明申请
    Water guns 失效
    水枪

    公开(公告)号：US20060226262A1

    公开(公告)日：2006-10-12

    申请号：US11366087

    申请日：2006-03-01

    申请人： Peter Chuang ,  George Eden ,  Kevin Hou ,  Francis Ponton ,  Chiu Wong

    发明人： Peter Chuang ,  George Eden ,  Kevin Hou ,  Francis Ponton ,  Chiu Wong

    IPC分类号： B05B1/32 ,  B05B9/01 ,  B05B7/02

    CPC分类号： B05B9/01 ,  B05B9/0426 ,  B05B9/085 ,  F04B9/14 ,  F41B9/0037

    摘要： A water gun may comprise a body having a front surface, a nozzle mounted on and extending from the body, an actuator, at least one fluid reservoir, and a pump. The nozzle may have at least a nozzle portion adapted to move between an extended position spaced away from the front surface and a retracted position closer to the front surface than the extended position. The actuator may be adapted to be moved relative to the body, and mechanically coupled to the nozzle for moving the nozzle between the retracted and extended positions when the actuator is moved between first and second positions. The fluid reservoir may comprise first and second end portions and a generally uniform elongate intermediate portion extending between the first and second end portions, which may have volumes that are larger than the volume of the intermediate portion. The pump may be fluidly coupled to the at least one reservoir and the nozzle, with the pump being operable to discharge fluid received from the at least one reservoir through the a nozzle.

    摘要翻译： 水枪可以包括具有前表面的主体，安装在主体上并且从主体延伸的喷嘴，致动器，至少一个流体储存器和泵。 喷嘴可以具有至少一个适于在与前表面间隔开的延伸位置和比伸出位置更靠近前表面的缩回位置之间移动的喷嘴部分。 致动器可以适于相对于主体移动，并且机械地联接到喷嘴，用于当致动器在第一和第二位置之间移动时，在缩回位置和伸出位置之间移动喷嘴。 流体储存器可以包括第一和第二端部以及在第一和第二端部之间延伸的大致均匀的细长的中间部分，其可以具有大于中间部分的体积的体积。 泵可以流体地联接到至少一个储存器和喷嘴，其中泵可操作以将通过喷嘴从至少一个储存器接收的流体排出。

    Water guns
    4.
    发明授权
    Water guns 失效
    水枪

    公开(公告)号：US07731064B2

    公开(公告)日：2010-06-08

    申请号：US11366087

    申请日：2006-03-01

    申请人： Peter Chuang ,  George Eden ,  Kevin Hou ,  Francis Ponton ,  Chiu Wah Wong

    发明人： Peter Chuang ,  George Eden ,  Kevin Hou ,  Francis Ponton ,  Chiu Wah Wong

    IPC分类号： B65D88/54

    CPC分类号： B05B9/01 ,  B05B9/0426 ,  B05B9/085 ,  F04B9/14 ,  F41B9/0037

    摘要： A water gun may comprise a body having a front surface, a nozzle mounted on and extending from the body, an actuator, at least one fluid reservoir, and a pump. The nozzle may have at least a nozzle portion adapted to move between an extended position spaced away from the front surface and a retracted position closer to the front surface than the extended position. The actuator may be adapted to be moved relative to the body, and mechanically coupled to the nozzle for moving the nozzle between the retracted and extended positions when the actuator is moved between first and second positions. The fluid reservoir may comprise first and second end portions and a generally uniform elongate intermediate portion extending between the first and second end portions, which may have volumes that are larger than the volume of the intermediate portion. The pump may be fluidly coupled to the at least one reservoir and the nozzle, with the pump being operable to discharge fluid received from the at least one reservoir through the a nozzle.

    摘要翻译： 水枪可以包括具有前表面的主体，安装在主体上并且从主体延伸的喷嘴，致动器，至少一个流体储存器和泵。 喷嘴可以具有至少一个适于在与前表面间隔开的延伸位置和比伸出位置更靠近前表面的缩回位置之间移动的喷嘴部分。 致动器可以适于相对于主体移动，并且机械地联接到喷嘴，用于当致动器在第一和第二位置之间移动时，在缩回位置和伸出位置之间移动喷嘴。 流体储存器可以包括第一和第二端部以及在第一和第二端部之间延伸的大致均匀的细长的中间部分，其可以具有大于中间部分的体积的体积。 泵可以流体地联接到至少一个储存器和喷嘴，其中泵可操作以将通过喷嘴从至少一个储存器接收的流体排出。

    Essential and important genes of Pseudomonas aeruginosa and the use thereof to design or identify antibacterial agents
    6.
    发明申请
    Essential and important genes of Pseudomonas aeruginosa and the use thereof to design or identify antibacterial agents 失效
    铜绿假单胞菌的基本重要基因及其用于设计或鉴定抗菌剂的用途

    公开(公告)号：US20070196829A1

    公开(公告)日：2007-08-23

    申请号：US11246458

    申请日：2005-10-11

    申请人： Kim Bruce ,  Paul Warrener ,  Kevin Hou

    发明人： Kim Bruce ,  Paul Warrener ,  Kevin Hou

    IPC分类号： C12Q1/68 ,  C12Q1/18

    CPC分类号： C07K14/21 ,  A61K38/00 ,  Y02A50/473

    摘要： The invention includes a database of candidate essential genes in Pseudomonas aeruginosa, as well as other important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and mutants of such genes are important for identifying antibacterial agents suitable for treating and preventing Pseudomonas aeruginosa infections. The invention includes methods for confirming the essentiality or importance of candidate genes, as well as methods for utilizing those genes to screen for new antibacterial drugs. The invention also includes the antibacterial agents identified using the disclosed methods, as well as methods of using the same for treating and preventing Pseudomonas infection.

    摘要翻译： 本发明包括铜绿假单胞菌中候选必需基因的数据库，以及突变时导致生长减弱表型的其他重要基因。 这些基因和这些基因的突变体对于鉴定适于治疗和预防铜绿假单胞菌感染的抗菌剂是重要的。 本发明包括确认候选基因的重要性或重要性的方法，以及利用这些基因筛选新的抗菌药物的方法。 本发明还包括使用所公开的方法鉴定的抗菌剂，以及使用该抗菌剂治疗和预防假单胞菌感染的方法。

    Random transposon insertion in Staphylococcus aureus and use thereof to identify essential genes
    7.
    发明授权
    Random transposon insertion in Staphylococcus aureus and use thereof to identify essential genes 失效
    金黄色葡萄球菌中的随机转座子插入及其用于鉴定必需基因

    公开(公告)号：US08173363B2

    公开(公告)日：2012-05-08

    申请号：US10525062

    申请日：2003-08-20

    申请人： Kim Folger Bruce ,  Paul Warrener ,  Jennifer McLarnan ,  Kevin Hou

    发明人： Kim Folger Bruce ,  Paul Warrener ,  Jennifer McLarnan ,  Kevin Hou

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  G01N33/48

    CPC分类号： C12N15/1082 ,  A61K38/00 ,  C07K14/31 ,  C12N15/1034

    摘要： The invention provides a method for generating a database of candidate essential genes in Staphylococcus aureus, as well as otherwise important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and mutants of such genes are important for identifying antibacterial agents suitable for treating and preventing S. aureus infections. The invention includes methods for confirming the essentiality or importance of candidate genes, as well as methods for utilizing those genes to screen for new antibacterial drugs. The invention also includes the antibacterial agents identified using the disclosed methods, as well as methods of using the same for treating and preventing Staphylococcus infection.

    摘要翻译： 本发明提供了一种在金黄色葡萄球菌中产生候选必需基因数据库的方法，以及突变时导致生长减弱表型的其他重要基因。 这些基因和这些基因的突变体对于鉴定适用于治疗和预防金黄色葡萄球菌感染的抗菌剂是重要的。 本发明包括确认候选基因的重要性或重要性的方法，以及利用这些基因筛选新的抗菌药物的方法。 本发明还包括使用所公开的方法鉴定的抗菌剂，以及其用于治疗和预防葡萄球菌感染的方法。

    Random transposon insertion in staphylococcus aureus and use thereof to identify essential genes
    8.
    发明申请
    Random transposon insertion in staphylococcus aureus and use thereof to identify essential genes 失效
    在金黄色葡萄球菌中随机转座子插入，并用于鉴定必需基因

    公开(公告)号：US20060234233A1

    公开(公告)日：2006-10-19

    申请号：US10525062

    申请日：2003-08-20

    申请人： Kim Bruce ,  Paul Warrener ,  Jennifer McLarnan ,  Kevin Hou

    发明人： Kim Bruce ,  Paul Warrener ,  Jennifer McLarnan ,  Kevin Hou

    IPC分类号： C40B40/08 ,  C12Q1/68 ,  G01N33/554 ,  C07H21/04 ,  C12P21/06 ,  C12N15/74 ,  C07K14/31 ,  G01N33/569

    CPC分类号： C12N15/1082 ,  A61K38/00 ,  C07K14/31 ,  C12N15/1034

    摘要： The invention provides a method for generating a database of candidate essential genes in Staphylococcus aureus, as well as otherwise important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and mutants of such genes are important for identifying antibacterial agents suitable for treating and preventing S. aureus infections. The invention includes methods for confirming the essentiality or importance of candidate genes, as well as methods for utilizing those genes to screen for new antibacterial drugs. The invention also includes the antibacterial agents identified using the disclosed methods, as well as methods of using the same for treating and preventing Staphylococcus infection.

    摘要翻译： 本发明提供了一种在金黄色葡萄球菌中产生候选必需基因数据库的方法，以及突变时导致生长减弱表型的其他重要基因。 这些基因和这些基因的突变体对于鉴定适用于治疗和预防金黄色葡萄球菌感染的抗菌剂是重要的。 本发明包括确认候选基因的重要性或重要性的方法，以及利用这些基因筛选新的抗菌药物的方法。 本发明还包括使用所公开的方法鉴定的抗菌剂，以及其用于治疗和预防葡萄球菌感染的方法。

    Essential and important genes of Pseudomonas aeruginosa and the use thereof to design or identify antibacterial agents
    9.
    发明授权
    Essential and important genes of Pseudomonas aeruginosa and the use thereof to design or identify antibacterial agents 失效
    铜绿假单胞菌的基本重要基因及其用于设计或鉴定抗菌剂的用途

    公开(公告)号：US07629141B2

    公开(公告)日：2009-12-08

    申请号：US11246458

    申请日：2005-10-11

    申请人： Kim Folger Bruce ,  Paul Warrener ,  Kevin Hou

    发明人： Kim Folger Bruce ,  Paul Warrener ,  Kevin Hou

    IPC分类号： C12Q1/18

    CPC分类号： C07K14/21 ,  A61K38/00 ,  Y02A50/473

    摘要： The invention includes a database of candidate essential genes in Pseudomonas aeruginosa, as well as other important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and mutants of such genes are important for identifying antibacterial agents suitable for treating and preventing Pseudomonas aeruginosa infections. The invention includes methods for confirming the essentiality or importance of candidate genes, as well as methods for utilizing those genes to screen for new antibacterial drugs. The invention also includes the antibacterial agents identified using the disclosed methods, as well as methods of using the same for treating and preventing Pseudomonas infection.

    摘要翻译： 本发明包括铜绿假单胞菌中候选必需基因的数据库，以及突变时导致生长减弱表型的其他重要基因。 这些基因和这些基因的突变体对于鉴定适于治疗和预防铜绿假单胞菌感染的抗菌剂是重要的。 本发明包括确认候选基因的重要性或重要性的方法，以及利用这些基因筛选新的抗菌药物的方法。 本发明还包括使用所公开的方法鉴定的抗菌剂，以及使用该抗菌剂治疗和预防假单胞菌感染的方法。