公开(公告)号：US20110229439A1

公开(公告)日：2011-09-22

申请号：US13063604

申请日：2009-09-11

申请人： Peter Humphries ,  Marian Humphries ,  Matthew Campbell ,  Paul Kenna ,  Lawrence Chi Shing Tam ,  Gwenyth Jane Farrar ,  Anna-Sophia Kiang

发明人： Peter Humphries ,  Marian Humphries ,  Matthew Campbell ,  Paul Kenna ,  Lawrence Chi Shing Tam ,  Gwenyth Jane Farrar ,  Anna-Sophia Kiang

IPC分类号： A61K35/76 ,  C07K14/435 ,  A61K38/16 ,  G01N33/53 ,  A61P27/02

CPC分类号： A61K38/1725

摘要： The present invention relates to classical pathway complement proteins and their use in the prognosis and prevention of diseases involving cone photoreceptor degeneration. Specifically, the present invention is directed to the use of one or more classical pathway complement proteins, preferably involved in the recognition phase, in the maintenance of cone photoreceptor cell viability in a degenerating retina. The invention is also directed to a method for determining the susceptibility, risk of development and/or progression of diseases involving cone photoreceptor degeneration in a subject.

摘要翻译： 本发明涉及经典途径补体蛋白及其在预后和预防涉及锥体感光器变性的疾病中的应用。 具体而言，本发明涉及一种或多种经典途径补体蛋白（优选参与识别阶段）在维持视网膜退行性视网膜中的锥体感光细胞活力的用途。 本发明还涉及用于确定受试者中涉及锥体感光器变性的疾病的易感性，发展风险和/或进展的方法。