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公开(公告)号：US08933228B2
公开(公告)日：2015-01-13
申请号：US13805471
申请日：2011-06-17
IPC分类号： A61K31/50 , C07D515/02 , C07D471/00 , C07D471/04 , A61K31/437 , A61K31/4985 , C07D487/04 , C07D473/30 , C07D475/02 , A61K9/00
CPC分类号： C07D471/04 , A61K9/0075 , A61K31/437 , A61K31/4985 , C07D473/30 , C07D475/02 , C07D487/04 , Y10T428/2982
摘要： The present invention relates to respiratory formulations comprising a compound of formula (I): and use of said compounds and compositions in treatment, for example in the treatment of an inflammatory disease or a respiratory disorder, in particular an inflammatory mediated and/or virally mediated respiratory disorder such as asthma and COPD or the treatment or prevention of viral infection, for example infection by influenza virus, rhinovirus or RSV. The invention also extends to certain novel compounds of formula (I).
摘要翻译： 本发明涉及包含式（I）化合物的呼吸制剂：以及所述化合物和组合物在治疗中的用途，例如治疗炎性疾病或呼吸障碍，特别是炎性介导和/或病毒介导的 呼吸障碍如哮喘和COPD或治疗或预防病毒感染，例如流感病毒，鼻病毒或RSV感染。 本发明还延伸到某些新的式（I）化合物。
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公开(公告)号：US08299074B2
公开(公告)日：2012-10-30
申请号：US13139010
申请日：2009-12-11
申请人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
发明人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
IPC分类号： A61K31/5377 , A61K31/505 , A61K31/445 , A61K31/4427 , C07D413/14 , C07D403/02 , C07D213/02 , C07D211/06
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present disclosure relates to compounds of formula (I): which are inhibitors of p38 mitogen-activated protein kinase enzymes, particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.
摘要翻译： 本公开涉及式（I）化合物：其是p38丝裂原活化蛋白激酶的抑制剂，特别是其α和γ激酶亚型的抑制剂及其在治疗中的用途，包括在药物组合中，特别是在治疗中 的炎性疾病，包括肺的炎性疾病，如COPD。
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公开(公告)号：US20110312963A1
公开(公告)日：2011-12-22
申请号：US13139010
申请日：2009-12-11
申请人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
发明人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
IPC分类号： A61K31/4439 , C07D405/14 , C07D413/14 , C07D401/14 , C07D403/12 , A61K31/5377 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61P11/00 , A61P11/06 , A61P17/00 , A61P37/08 , A61P11/02 , A61P27/02 , A61P27/14 , A61P17/06 , A61P1/04 , A61P29/00 , A61P19/02 , A61P1/18 , A61P3/00 , A61P35/00 , A61P35/04 , C07D401/12
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present disclosure relates to compounds of formula (I): which are inhibitors of p38 mitogen-activated protein kinase enzymes, particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD
摘要翻译： 本公开涉及式（I）化合物：其是p38丝裂原活化蛋白激酶的抑制剂，特别是其α和γ激酶亚型的抑制剂及其在治疗中的用途，包括在药物组合中，特别是在治疗中 的炎性疾病，包括肺的炎性疾病，如COPD
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公开(公告)号：US20130156826A1
公开(公告)日：2013-06-20
申请号：US13805471
申请日：2011-06-17
IPC分类号： C07D471/04 , C07D475/02 , C07D473/30
CPC分类号： C07D471/04 , A61K9/0075 , A61K31/437 , A61K31/4985 , C07D473/30 , C07D475/02 , C07D487/04 , Y10T428/2982
摘要： The present invention relates to respiratory formulations comprising a compound of formula (I): and use of said compounds and compositions in treatment, for example in the treatment of an inflammatory disease or a respiratory disorder, in particular an inflammatory mediated and/or virally mediated respiratory disorder such as asthma and COPD or the treatment or prevention of viral infection, for example infection by influenza virus, rhinovirus or RSV. The invention also extends to certain novel compounds of formula (I).
摘要翻译： 本发明涉及包含式（I）化合物的呼吸制剂：以及所述化合物和组合物在治疗中的用途，例如治疗炎性疾病或呼吸障碍，特别是炎性介导和/或病毒介导的 呼吸障碍如哮喘和COPD或治疗或预防病毒感染，例如流感病毒，鼻病毒或RSV感染。 本发明还延伸到某些新的式（I）化合物。
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