公开(公告)号：US07772386B1

公开(公告)日：2010-08-10

申请号：US09890339

申请日：2000-01-28

申请人： Peter Jungblut ,  Stefan H. E. Kaufmann ,  Ulrich Schaible ,  Hans Mollenkopf ,  Bärbel Raupach ,  Ursula Zimny-Arndt ,  Stephanie Lamer ,  Jens Mattow

发明人： Peter Jungblut ,  Stefan H. E. Kaufmann ,  Ulrich Schaible ,  Hans Mollenkopf ,  Bärbel Raupach ,  Ursula Zimny-Arndt ,  Stephanie Lamer ,  Jens Mattow

IPC分类号： C07H21/04 ,  A61K39/04

CPC分类号： A61K39/04 ,  A61K2039/53 ,  C07K14/35 ,  C07K2319/00

摘要： The present invention relates to compositions useful in immunization against pathogenic organisms of the genus Mycobacterium and for diagnostic purposes. In particular, the present invention relates to a composition comprising at least one protein which is differentially expressed in a virulent strain as compared to an avirulent strain of Mycobacteria. Furthermore, the invention relates to compositions comprising fusion proteins, antigenic fragments, nucleic acid molecules encoding the aforementioned proteinaceous compounds and/or antibodies thereto. Additionally, the invention relates to pharmaceutical and diagnostic compositions comprising or employing compounds of the invention. In addition, the present invention relates to the use of the compounds of the invention for the treatment of Mycobacterium induced diseases and/or for the preparation of a vaccine for vaccination against Mycobacterium induced diseases.

摘要翻译： 本发明涉及可用于针对分枝杆菌属的病原微生物免疫的组合物和用于诊断目的。 特别地，本发明涉及一种组合物，其包含至少一种与分枝杆菌的无毒力菌株相比在毒力菌株中差异表达的蛋白质。 此外，本发明涉及包含融合蛋白，抗原性片段，编码上述蛋白质化合物的核酸分子和/或其抗体的组合物。 另外，本发明涉及包含或使用本发明化合物的药物和诊断组合物。 此外，本发明涉及本发明化合物用于治疗分枝杆菌诱导的疾病和/或用于制备针对分枝杆菌诱导的疾病的疫苗接种的用途。