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公开(公告)号：US07772386B1
公开(公告)日：2010-08-10
申请号：US09890339
申请日：2000-01-28
申请人： Peter Jungblut , Stefan H. E. Kaufmann , Ulrich Schaible , Hans Mollenkopf , Bärbel Raupach , Ursula Zimny-Arndt , Stephanie Lamer , Jens Mattow
发明人： Peter Jungblut , Stefan H. E. Kaufmann , Ulrich Schaible , Hans Mollenkopf , Bärbel Raupach , Ursula Zimny-Arndt , Stephanie Lamer , Jens Mattow
CPC分类号： A61K39/04 , A61K2039/53 , C07K14/35 , C07K2319/00
摘要： The present invention relates to compositions useful in immunization against pathogenic organisms of the genus Mycobacterium and for diagnostic purposes. In particular, the present invention relates to a composition comprising at least one protein which is differentially expressed in a virulent strain as compared to an avirulent strain of Mycobacteria. Furthermore, the invention relates to compositions comprising fusion proteins, antigenic fragments, nucleic acid molecules encoding the aforementioned proteinaceous compounds and/or antibodies thereto. Additionally, the invention relates to pharmaceutical and diagnostic compositions comprising or employing compounds of the invention. In addition, the present invention relates to the use of the compounds of the invention for the treatment of Mycobacterium induced diseases and/or for the preparation of a vaccine for vaccination against Mycobacterium induced diseases.
摘要翻译： 本发明涉及可用于针对分枝杆菌属的病原微生物免疫的组合物和用于诊断目的。 特别地，本发明涉及一种组合物，其包含至少一种与分枝杆菌的无毒力菌株相比在毒力菌株中差异表达的蛋白质。 此外，本发明涉及包含融合蛋白，抗原性片段，编码上述蛋白质化合物的核酸分子和/或其抗体的组合物。 另外，本发明涉及包含或使用本发明化合物的药物和诊断组合物。 此外，本发明涉及本发明化合物用于治疗分枝杆菌诱导的疾病和/或用于制备针对分枝杆菌诱导的疾病的疫苗接种的用途。
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公开(公告)号：US07988980B2
公开(公告)日：2011-08-02
申请号：US10554408
申请日：2004-04-23
CPC分类号： C07K14/35 , A61K39/00 , C07K14/195 , C07K2319/00
摘要： The present invention relates to novel recombinant vaccines providing protective immunity against tuberculosis. Further, the present invention refers to novel recombinant nucleic acid molecules, vectors containing said nucleic acid molecules, cells transformed with said nucleic acid molecules and polypeptides encoded by said nucleic acid molecules.
摘要翻译： 本发明涉及提供针对结核病的保护性免疫的新型重组疫苗。 此外，本发明涉及新型重组核酸分子，含有所述核酸分子的载体，用所述核酸分子转化的细胞和由所述核酸分子编码的多肽。
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公开(公告)号：US06673353B1
公开(公告)日：2004-01-06
申请号：US09485717
申请日：2000-02-22
申请人： Stefan H. E. Kaufmann , Jürgen Hess
发明人： Stefan H. E. Kaufmann , Jürgen Hess
IPC分类号： A61K3902
CPC分类号： C07K14/195 , A61K38/00 , C07K14/35 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N15/62
摘要： The present invention relates to novel recombinant vaccines providing protective immunity against tuberculosis. Further, the present invention refers to novel recombinant nucleic acid molecules, vectors containing said nucleic acid molecules, cells transformed with said nucleic acid molecules and polypeptides encoded by said nucleic acid molecules.
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公开(公告)号：US08906389B2
公开(公告)日：2014-12-09
申请号：US13996832
申请日：2011-12-21
CPC分类号： G01N33/6869 , A61K39/04 , G01N33/505 , G01N33/5091 , G01N2333/35 , G01N2800/52
摘要： The invention relates to methods and reagents for determining efficacy of vaccine, particularly of a tuberculosis vaccine.
摘要翻译： 本发明涉及用于确定疫苗，特别是结核病疫苗的功效的方法和试剂。
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公开(公告)号：US08545854B2
公开(公告)日：2013-10-01
申请号：US13165904
申请日：2011-06-22
CPC分类号： C07K14/35 , A61K39/00 , C07K14/195 , C07K2319/00
摘要： The present invention relates to novel recombinant vaccines providing protective immunity against tuberculosis. Further, the present invention refers to novel recombinant nucleic acid molecules, vectors containing said nucleic acid molecules, cells transformed with said nucleic acid molecules and polypeptides encoded by said nucleic acid molecules.
摘要翻译： 本发明涉及提供针对结核病的保护性免疫的新型重组疫苗。 此外，本发明涉及新型重组核酸分子，含有所述核酸分子的载体，用所述核酸分子转化的细胞和由所述核酸分子编码的多肽。
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公开(公告)号：US06776993B2
公开(公告)日：2004-08-17
申请号：US09948722
申请日：2001-09-10
申请人： Stefan H. E. Kaufmann , Jürgen Hess
发明人： Stefan H. E. Kaufmann , Jürgen Hess
IPC分类号： A61K3902
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/523 , A61K2039/53 , C07K14/195 , C07K2319/00
摘要： The present invention relates to novel recombinant vaccines providing protective immunity against tuberculosis. Further, the present invention refers to novel recombinant nucleic acid molecules, vectors containing said nucleic acid molecules, cells transformed with said nucleic acid molecules and polypeptides encoded by said nucleic acid molecules.
摘要翻译： 本发明涉及提供针对结核病的保护性免疫的新型重组疫苗。 此外，本发明涉及新型重组核酸分子，含有所述核酸分子的载体，用所述核酸分子转化的细胞和由所述核酸分子编码的多肽。
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公开(公告)号：US09328350B2
公开(公告)日：2016-05-03
申请号：US13996802
申请日：2011-12-21
IPC分类号： A61K39/02 , A61K39/04 , A61K39/00 , A61K39/38 , A61K45/00 , C12N1/20 , C12N1/12 , C12N15/74 , C07K14/35 , A61K38/00
CPC分类号： C12N15/74 , A61K38/00 , A61K39/0241 , A61K39/04 , A61K2039/52 , A61K2039/522 , A61K2039/523 , A61K2039/57 , C07K14/35 , G01N33/505 , G01N33/5091 , G01N2333/35 , G01N2800/52
摘要： The invention relates to a recombinant Mycobacterium cell for use as a vaccine.
摘要翻译： 本发明涉及用作疫苗的重组分枝杆菌细胞。
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公开(公告)号：US20080280848A1
公开(公告)日：2008-11-13
申请号：US12091937
申请日：2006-10-27
IPC分类号： A61K31/7088 , C07H21/02 , C12Q1/68 , A61P43/00 , C12P19/34
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/50 , G16B15/00
摘要： The present invention relates to methods and compositions for modulating RNA silencing efficiency by providing selective RISC (RNA-induced silencing complex) formation. The present invention also relates to methods for identifying nucleic acids and/or determining their structures.
摘要翻译： 本发明涉及通过提供选择性RISC（RNA诱导的沉默复合物）形成来调节RNA沉默效率的方法和组合物。 本发明还涉及用于鉴定核酸和/或确定其结构的方法。
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