公开(公告)号：US20070207160A1

公开(公告)日：2007-09-06

申请号：US11705956

申请日：2007-02-14

申请人： Peter Krammer ,  Michael Westendorp ,  Klaus Schulze-Osthoff ,  Klaus-Michael Debatin ,  Rainer Frank ,  Jens Dhein ,  Henning Walczak ,  Eckart Knipping ,  Kirstin Stricker

发明人： Peter Krammer ,  Michael Westendorp ,  Klaus Schulze-Osthoff ,  Klaus-Michael Debatin ,  Rainer Frank ,  Jens Dhein ,  Henning Walczak ,  Eckart Knipping ,  Kirstin Stricker

IPC分类号： A61K39/00

CPC分类号： C07K16/2878 ,  A61K38/55 ,  A61K2039/505 ,  C07K14/70578 ,  C07K2317/54 ,  C07K2319/00 ,  C07K2319/30

摘要： This invention relates to compositions for inhibiting apoptosis, containing one to all components of: (a) an APO-1-inhibiting compound; (b) a compound inhibiting and catching, respectively, the APO-1 ligand; and (c) a compound inhibiting the intracellular APO-1 signalling pathway, the component(s) being not considered foreign in an individual, as well as conventional excipients. Furthermore, this invention relates to compounds suitable for inhibiting apoptosis and having at least one extracellular APO-1 domain and a carrier, the domain(s) and the carrier being not considered foreign in an individual.

摘要翻译： 本发明涉及抑制细胞凋亡的组合物，其含有以下组分之一：（a）APO-1抑制化合物; （b）分别抑制和捕获APO-1配体的化合物; 和（c）抑制细胞内APO-1信号传导途径的化合物，所述组分在个体中不被认为是外源的，以及常规的赋形剂。 此外，本发明涉及适用于抑制凋亡并具有至少一个细胞外APO-1结构域和载体的化合物，所述结构域和载体在个体中不被认为是外源的。