公开(公告)号：US20070207160A1

公开(公告)日：2007-09-06

申请号：US11705956

申请日：2007-02-14

申请人： Peter Krammer ,  Michael Westendorp ,  Klaus Schulze-Osthoff ,  Klaus-Michael Debatin ,  Rainer Frank ,  Jens Dhein ,  Henning Walczak ,  Eckart Knipping ,  Kirstin Stricker

发明人： Peter Krammer ,  Michael Westendorp ,  Klaus Schulze-Osthoff ,  Klaus-Michael Debatin ,  Rainer Frank ,  Jens Dhein ,  Henning Walczak ,  Eckart Knipping ,  Kirstin Stricker

IPC分类号： A61K39/00

CPC分类号： C07K16/2878 ,  A61K38/55 ,  A61K2039/505 ,  C07K14/70578 ,  C07K2317/54 ,  C07K2319/00 ,  C07K2319/30

摘要： This invention relates to compositions for inhibiting apoptosis, containing one to all components of: (a) an APO-1-inhibiting compound; (b) a compound inhibiting and catching, respectively, the APO-1 ligand; and (c) a compound inhibiting the intracellular APO-1 signalling pathway, the component(s) being not considered foreign in an individual, as well as conventional excipients. Furthermore, this invention relates to compounds suitable for inhibiting apoptosis and having at least one extracellular APO-1 domain and a carrier, the domain(s) and the carrier being not considered foreign in an individual.

摘要翻译： 本发明涉及抑制细胞凋亡的组合物，其含有以下组分之一：（a）APO-1抑制化合物; （b）分别抑制和捕获APO-1配体的化合物; 和（c）抑制细胞内APO-1信号传导途径的化合物，所述组分在个体中不被认为是外源的，以及常规的赋形剂。 此外，本发明涉及适用于抑制凋亡并具有至少一个细胞外APO-1结构域和载体的化合物，所述结构域和载体在个体中不被认为是外源的。

公开(公告)号：US20070243577A1

公开(公告)日：2007-10-18

申请号：US11598199

申请日：2006-11-13

申请人： Marek Los ,  Andrea Renz ,  Klaus Schulze-Osthoff ,  Wolfgang Berdel

发明人： Marek Los ,  Andrea Renz ,  Klaus Schulze-Osthoff ,  Wolfgang Berdel

IPC分类号： C12Q1/18 ,  C12N5/00

CPC分类号： C12N9/0006 ,  A61K38/00 ,  C07K14/80 ,  G01N33/573 ,  G01N33/6896 ,  G01N2333/80 ,  G01N2333/904

摘要： A method for the detection of apoptosis by determining presence, amount, or activity of apoptosis-specific markers released from at least one cell undergoing apoptosis into an extracellular medium through cellular release mechanisms is disclosed. The extracellular medium includes body fluids, in particular urine, inflammatory fluid, serum, liquor, or cell culture medium, wherein samples are preferably taken from humans or animals. The method can be used for the diagnosis and/or for therapy control of diseases and/or processes associated with increased apoptosis. It can also be used for therapy control of diseases associated with decreased apoptosis. Additionally, a method is disclosed for the identification of apoptosis-modulating substances, characterized in that apoptosis-specific markers released from a cell culture sample into an extracellular cell culture medium through cellular release mechanisms are determined. The invention also concerns the use of an apoptosis detection kit for determining extracellular apoptosis-specific markers. It further relates to the use of cytochrome c and/or peptides derived thereof as a medicament, pharmaceutical compositions comprising cytochrome c and/or peptides derived thereof, and optionally a pharmaceutically acceptable carrier, and the use of cytochrome c and/or peptides derived thereof, for the preparation of a medicament for the treatment of diseases with inflammatory manifestation.

摘要翻译： 公开了一种通过将细胞释放机制从至少一个经历细胞凋亡的细胞释放的细胞凋亡特异性标记物的存在，量或活性测定来检测细胞凋亡的方法。 细胞外培养基包括体液，特别是尿液，炎性液体，血清，液体或细胞培养基，其中样品优选取自人或动物。 该方法可用于与增加的凋亡相关的疾病和/或过程的诊断和/或治疗控制。 它也可用于与凋亡减少相关的疾病的治疗控制。 此外，公开了用于鉴定凋亡调节物质的方法，其特征在于确定通过细胞释放机制从细胞培养物样品释放到细胞外细胞培养基中的凋亡特异性标记。 本发明还涉及凋亡检测试剂盒用于测定细胞外凋亡特异性标记物的用途。 它还涉及使用其衍生的细胞色素c和/或肽作为药物，包含衍生自其的细胞色素c和/或肽的药物组合物，以及任选的药学上可接受的载体，以及衍生自其的细胞色素c和/或肽的用途 ，用于制备用于治疗具有炎性表现的疾病的药物。