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公开(公告)号：US20080020984A1
公开(公告)日：2008-01-24
申请号：US11781738
申请日：2007-07-23
申请人： Peter Kuhn , Anand Kolatkar , Alexei Brooun , Jill Chrencik , Michelle Kraus
发明人： Peter Kuhn , Anand Kolatkar , Alexei Brooun , Jill Chrencik , Michelle Kraus
CPC分类号： C07K14/715 , C07K2299/00 , G01N2333/91215 , G01N2500/00 , G16B15/00
摘要： The invention relates to the three-dimensional structure of a crystal of an EphB4 receptor complexed with a ligand. The three-dimensional structure of a Receptor-Ligand Complex is disclosed. The receptor-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug screening and drug design processes. Thus, the invention also relates to methods for utilizing the crystal structure of the Receptor-Ligand Complex for identifying, designing, selecting, or testing inhibitors of the EphB4 receptor protein, such inhibitors being useful as therapeutics for the treatment or modulation of i) diseases; ii) disease symptoms; or iii) the effect of other physiological events mediated by the receptor.
摘要翻译： 本发明涉及与配体络合的EphB4受体的晶体的三维结构。 公开了受体配体复合物的三维结构。 受体 - 配体晶体结构，其中配体是抑制剂分子，可用于提供可被整合到药物筛选和药物设计过程中的结构信息。 因此，本发明还涉及利用受体配体复合物的晶体结构鉴定，设计，选择或测试EphB4受体蛋白质的抑制剂的方法，所述抑制剂可用作治疗或调节i）疾病 ; ii）疾病症状; 或iii）由受体介导的其它生理事件的作用。
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公开(公告)号：US20080064052A1
公开(公告)日：2008-03-13
申请号：US11622785
申请日：2007-01-12
申请人： Peter Kuhn , Anand Kolaktar , Alexei Brooun , Jill Chrencik , Michelle Kraus
发明人： Peter Kuhn , Anand Kolaktar , Alexei Brooun , Jill Chrencik , Michelle Kraus
摘要： The invention relates to the three-dimensional structure of a crystal of an EphB4 receptor complexed with a ligand. The three-dimensional structure of a Receptor-Ligand Complex is disclosed. The receptor-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug screening and drug design processes. Thus, the invention also relates to methods for utilizing the crystal structure of the Receptor-Ligand Complex for identifying, designing, selecting, or testing inhibitors of the EphB4 receptor protein, such inhibitors being useful as therapeutics for the treatment or modulation of i) diseases; ii) disease symptoms; or iii) the effect of other physiological events mediated by the receptor.
摘要翻译： 本发明涉及与配体络合的EphB4受体的晶体的三维结构。 公开了受体配体复合物的三维结构。 受体 - 配体晶体结构，其中配体是抑制剂分子，可用于提供可被整合到药物筛选和药物设计过程中的结构信息。 因此，本发明还涉及利用受体配体复合物的晶体结构鉴定，设计，选择或测试EphB4受体蛋白质的抑制剂的方法，所述抑制剂可用作治疗或调节i）疾病 ; ii）疾病症状; 或iii）由受体介导的其它生理事件的作用。
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