公开(公告)号：US5929251A

公开(公告)日：1999-07-27

申请号：US565

申请日：1997-12-30

申请人： Peter Pochlauer ,  Wolfram Hendel ,  Christian Burger ,  Anita Lamplmayr ,  Harald Poschko ,  Antonia Praus ,  Gerald Summer

发明人： Peter Pochlauer ,  Wolfram Hendel ,  Christian Burger ,  Anita Lamplmayr ,  Harald Poschko ,  Antonia Praus ,  Gerald Summer

IPC分类号： B01J23/04 ,  B01J27/232 ,  B01J31/02 ,  C07B61/00 ,  C07D207/46 ,  C07D207/12

CPC分类号： C07D207/46

摘要： Process for the preparation of carboxylic acid succinimidyl esters by reaction of N-hydroxysuccinimide with a carboxylic acid and a halophosphoric acid ester of the formula ##STR1## in which R.sub.1 and R.sub.2 are identical or different and are a C.sub.2 - to C.sub.6 -alkyl radical or a phenyl radical, or R.sub.1 and R.sub.2 together form a C.sub.6 -aryl radical, in the presence of a base in a diluent at a temperature of 0.degree. C. up to 100.degree. C. and isolation of the corresponding carboxylic acid succinimidyl ester.

摘要翻译： 通过N-羟基琥珀酰亚胺与羧酸和下式的卤代磷酸酯的反应制备羧酸琥珀酰亚胺酯的方法，其中R 1和R 2相同或不同，并且是C 2 -C 6烷基或苯基 或者R1和R2一起形成C 6 - 芳基，在碱存在下，在稀释剂中，在0℃至100℃的温度下，分离相应的羧酸琥珀酰亚胺酯。

公开(公告)号：US5734064A

公开(公告)日：1998-03-31

申请号：US833120

申请日：1997-04-04

申请人： Peter Pochlauer ,  Wolfram Hendel ,  Christian Burger ,  Anita Lamplmayr ,  Harald Poschko ,  Antonia Praus ,  Gerald Summer

发明人： Peter Pochlauer ,  Wolfram Hendel ,  Christian Burger ,  Anita Lamplmayr ,  Harald Poschko ,  Antonia Praus ,  Gerald Summer

IPC分类号： B01J23/04 ,  B01J27/232 ,  B01J31/02 ,  C07B61/00 ,  C07D207/46

CPC分类号： C07D207/46

摘要： A process for the preparation of carboxylic acid succinimidyl esters by reaction of N-hydroxysuccinimide with a carboxylic acid and a halophosphoric acid ester of the formula ##STR1## is desired, in which R.sub.1 and R.sub.2 are identical or different and are a C.sub.2 - to C.sub.6 -alkyl radical or a phenyl radical, or R.sub.1 and R.sub.2 The process is carried out in the presence of a base in a diluent at a temperature of 0.degree. C. up to 100.degree. C. with isolation of the corresponding carboxylic acid succinimidyl ester.

摘要翻译： 需要通过N-羟基琥珀酰亚胺与羧酸和式I的卤代磷酸酯反应来制备羧酸琥珀酰亚胺酯的方法，其中R1和R2相同或不同，为C2- C 6 - 烷基或苯基，或R 1和R 2。该方法在碱存在下，在稀释剂中，在0℃至100℃的温度下进行，分离相应的羧酸琥珀酰亚胺酯 。