公开(公告)号：US20240199542A1

公开(公告)日：2024-06-20

申请号：US18551766

申请日：2022-03-18

Applicant: Bayer Aktiengesellschaft

Inventor： Lars ARVE ,  Jens FRACKENPOHL ,  Hansjörg DIETRICH ,  Ines HEINEMANN ,  Jan DITTGEN ,  Dirk SCHMUTZLER ,  Elmar GATZWEILER ,  Anna Maria REINGRUBER ,  Birgit BOLLENBACH-WAHL

IPC: C07D207/46 ,  A01N43/36 ,  A01N43/40 ,  A01N43/653 ,  A01N43/82 ,  A01P13/00 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D207/46 ,  A01N43/36 ,  A01N43/40 ,  A01N43/653 ,  A01N43/82 ,  A01P13/00 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to substituted pyrrolidin-2-ones of the general formula (I) or salts thereof,




where the radicals in the general formula (I) correspond to the definitions given in the description, and to their use as herbicides, in particular for controlling broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants.

公开(公告)号：US20230406822A1

公开(公告)日：2023-12-21

申请号：US18209583

申请日：2023-06-14

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Sunhye HWANG ,  Sunggi KIM ,  Yeonghun KIM ,  Gyunsang LEE ,  Jihyun LEE ,  Gyuhee PARK ,  Seung SON ,  Younjoung CHO ,  Byungkeun HWANG

IPC: C07D207/46 ,  C07D265/32 ,  C07D403/12 ,  H01L21/02

CPC classification number: C07D207/46 ,  C07D265/32 ,  C07D403/12 ,  H01L21/0214 ,  H01L21/02219 ,  H01L21/02216 ,  H01L21/0228

Abstract: A silicon compound, a composition, and associated methods, the silicon compound being represented by Chemical Formula (1):


R1m(OR2)n(OR3)3-m-nSi—O—SiR4p(OR5)q(OR6)3-p-q,  Chemical Formula (1)



wherein, in Chemical Formula (1), m, n, p, and q are each independently an integer of 0 to 3, and satisfy the following relations m+p≥1, m+n≤3, and p+q≤3, R1 is a heterocyclic group, R4 is a heterocyclic group, a carbon saturated group, or a carbon unsaturated group, and R2, R3, R5, and R6 are each independently a hydrogen atom, a C1-C7 alkyl group, a C2-C7 alkenyl group, a C3-C7 cycloalkyl group, or a C3-C7 cycloalkenyl group.

公开(公告)号：US20230295077A1

公开(公告)日：2023-09-21

申请号：US17995857

申请日：2021-04-09

Applicant: FRESENIUS KABI ONCOLOGY LIMITED

Inventor： Maneesh Kumar PANDEY ,  Sonu Prasad SHUKLA ,  Sachin NAIN ,  Sandeep SANDEEP ,  Sridhar MALE ,  Sarbjot Singh SOKHI ,  Govind SINGH ,  Saswata LAHIRI ,  Walter CABRI

IPC: C07C269/06 ,  C07C231/02 ,  C07C231/12 ,  C07D207/46 ,  C07D249/18

CPC classification number: C07C269/06 ,  C07C231/02 ,  C07C231/12 ,  C07D207/46 ,  C07D249/18

Abstract: The present invention relates to an improved process for the preparation of a compound of Formula (1), The invention also provides improved processes for the preparation of intermediates used in the synthesis of Formula (1). The compound of Formula (1) is used in the synthesis of Semaglutide.

公开(公告)号：US20180339968A1

公开(公告)日：2018-11-29

申请号：US16049434

申请日：2018-07-30

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D211/78 ,  C07D223/10 ,  C07D309/04 ,  C07D207/16 ,  C07D211/60 ,  C07D211/90 ,  C07D207/277 ,  C07D207/273 ,  C07D207/267 ,  C07D309/30 ,  C07D211/96 ,  C07D211/94 ,  C07D211/88 ,  C07D211/76 ,  C07D211/38 ,  C07D211/34 ,  C07D211/22 ,  C07D211/18 ,  C07D211/16 ,  C07D207/46 ,  C07D207/27 ,  C07D207/263 ,  C07D207/26 ,  C07D207/10 ,  C07D207/08 ,  C07D265/30 ,  C07D207/06 ,  C07D241/52 ,  C07D241/08 ,  C07D241/04 ,  C07D223/04 ,  C07D265/32

CPC classification number: C07D211/78 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/16 ,  C07D207/26 ,  C07D207/263 ,  C07D207/267 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/60 ,  C07D211/76 ,  C07D211/88 ,  C07D211/90 ,  C07D211/94 ,  C07D211/96 ,  C07D223/04 ,  C07D223/10 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D265/30 ,  C07D265/32 ,  C07D309/04 ,  C07D309/30

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US20180297947A1

公开(公告)日：2018-10-18

申请号：US15912121

申请日：2018-03-05

Applicant: Johnny Russo ,  Gerald M. Rosen ,  David I. Bigio

Inventor： Johnny Russo ,  Gerald M. Rosen ,  David I. Bigio

IPC: C07D207/46 ,  H01L31/04 ,  G21H1/02 ,  C07B59/00

CPC classification number: C07D207/46 ,  C07B59/002 ,  C07B2200/05 ,  C08F38/00 ,  G21H1/02 ,  G21H1/06 ,  H01L31/04 ,  H02J7/0052

Abstract: Long-term and high-density energy sources are described that utilize radioisotope batteries that provide a tritium (3H)-based direct energy conversion system. The beta radiation source is a nitroxide compound with a synthetic yield near 100%. The nitroxide compound can be molded into flexible films to cover multiple structures, and has a specific activity and gravimetric density (wt % 3H) comparable to that of tritiated hydrides. A carrier system based on such tritiated nitroxides can be scaled up without significant beta self-absorption, permitting the energy source to have higher specific volume power densities than current radioisotope batteries. Such a carrier can be applied directly to a semiconductor array (such as an integrated circuit) in order to provide electrical power or, alternatively, be prepared with a phosphor and applied to a photovoltaic cell.

公开(公告)号：US20180274025A1

公开(公告)日：2018-09-27

申请号：US15928562

申请日：2018-03-22

Applicant: Intelligent BioSystems, Inc.

Inventor： Mong Sano Marma ,  Jerzy Olejnik ,  Ilia Korboukh

IPC: C12Q1/6869

CPC classification number: C07H19/10 ,  C07C323/12 ,  C07C323/60 ,  C07C2603/18 ,  C07D207/46 ,  C07F7/1804 ,  C07H19/14 ,  C09B1/00 ,  C09B5/2436 ,  C09B11/24 ,  C09B23/083 ,  C09B23/166 ,  C12Q1/6811 ,  C12Q1/6869 ,  C12Q1/6876 ,  Y02P20/55

Abstract: The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

公开(公告)号：US10077463B2

公开(公告)日：2018-09-18

申请号：US14995716

申请日：2016-01-14

Applicant: President and Fellows of Harvard College

Inventor： Adam E. Cohen ,  Miao-Ping Chien

IPC: C12N5/00 ,  C12Q1/24 ,  C07D207/46 ,  C07D495/04 ,  G01N21/64 ,  G01N33/58 ,  C09B23/00 ,  G01N33/50

CPC classification number: C12Q1/24 ,  C07D207/46 ,  C07D495/04 ,  C09B23/00 ,  C09B23/06 ,  C09B23/083 ,  C12N5/0006 ,  C12N5/0081 ,  G01N21/6428 ,  G01N33/5026 ,  G01N33/582 ,  G01N2021/6439

Abstract: Provided herein are photochemical crosslinkers and photocleavable crosslinkers and their uses in methods for cell selection from cell cultures. The photochemical crosslinkers comprise a fluorescent dye and a radical generator. The photocleavable crosslinkers comprise a photocleavable linker linking two electrophilic groups to each other. Also provided are systems for imaging cells comprising a plurality of cells crosslinked to extracellular matrix proteins using a crosslinker as described, an imaging apparatus, an illuminating apparatus, and software for image processing.

公开(公告)号：US10071163B2

公开(公告)日：2018-09-11

申请号：US14949490

申请日：2015-11-23

Applicant: nLife Therapeutics, S.L.

Inventor： Andrés Pablo Montefeltro ,  Gabriel Alvarado Urbina ,  Analia Bortolozzi Biassoni ,  Francesc Artigas Pérez ,  Miquel Vila Bover ,  Maria del Carmen Carmona Orozco

IPC: C07H21/04 ,  A61K47/48 ,  A61K49/00 ,  C12N15/11 ,  C12N15/113 ,  A61K31/135 ,  A61K31/472 ,  A61K31/7105 ,  A61K31/713 ,  C07D207/46 ,  C07D217/04 ,  A61K47/60 ,  A61K47/54 ,  A61K47/55

CPC classification number: A61K47/54 ,  A61K31/135 ,  A61K31/472 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/543 ,  A61K47/549 ,  A61K47/55 ,  A61K47/60 ,  A61K49/0002 ,  C07D207/46 ,  C07D217/04 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/32 ,  C12N2310/3521

Abstract: The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a neurotransmitter transporter. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interests and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of imaging agents to the cells for diagnostic purposes.

公开(公告)号：US20180251815A1

公开(公告)日：2018-09-06

申请号：US15756843

申请日：2016-09-02

Applicant: THE UNIVERSITY OF TOKYO

Inventor： Akimitsu OKAMOTO ,  Taku MATSUSHITA

IPC: C12Q1/6806 ,  C12Q1/6869

CPC classification number: C12Q1/6806 ,  C07D207/46 ,  C07D211/94 ,  C07D451/14 ,  C12N15/09 ,  C12Q1/6869 ,  C12Q2523/113 ,  C12Q2523/125

Abstract: The purpose of the present invention is to develop and provide a less expensive and novel oxidizing agent for 5-hydroxymethylcytosine, which can selectively oxidize 5-hydroxymethylcytosine on DNA into 5-formylcytosine while preventing the DNA structure from destabilization and suppressing side reactions, and a method for detecting a demethylation site at a high accuracy in demethylation of DNA with the use of the aforesaid oxidizing agent.Provided is an oxidizing agent for 5-hydroxymethylcytosine that comprises a nitroxyl radical molecule and a copper salt or a copper complex, and/or a nitroxyl radical molecule-copper complex.

公开(公告)号：US10053423B2

公开(公告)日：2018-08-21

申请号：US15109608

申请日：2015-01-02

Applicant: NUtech Ventures

Inventor： Stephen DiMagno ,  Bao Hu

IPC: C07D251/08 ,  C07D207/404 ,  C07D207/46 ,  C07C227/16 ,  C07D207/40 ,  A61K51/04 ,  C07D231/12

CPC classification number: C07D207/40 ,  A61K51/04 ,  C07C227/16 ,  C07D207/404 ,  C07D207/46 ,  C07D231/12 ,  C07D251/08

Abstract: This disclosure relates to reagents and methods useful in the synthesis of aryl iodines, for example, in the preparation of iodine labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.