公开(公告)号：US06262242B1

公开(公告)日：2001-07-17

申请号：US08791115

申请日：1997-01-30

申请人： Peter Steck ,  Mark A. Pershouse ,  Samar A. Jasser ,  W. K. Alfred Yung ,  Sean V. Tavtigian

发明人： Peter Steck ,  Mark A. Pershouse ,  Samar A. Jasser ,  W. K. Alfred Yung ,  Sean V. Tavtigian

IPC分类号： C07H204

CPC分类号： C12N9/16 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4703 ,  C12N2799/021

摘要： A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.

摘要翻译： 染色体10的特定区域（10q23.3）已被一系列研究涉及到包含参与神经胶质瘤的肿瘤抑制基因以及许多其他人类癌症。 鉴定出该区域内的一个基因，该基因的相应编码区代表一种新的47kD蛋白。 该产品的结构域与蛋白酪氨酸磷酸酶的保守催化结构域完全一致，表明在磷酸化事件中可能发挥功能作用。 序列分析表明，在用于定义10q23.3区域的肿瘤细胞系中，该基因的多个外显子被缺失，导致该基因作为肿瘤抑制基因的分类。 进一步的分析已经证明在神经胶质瘤和前列腺癌细胞中基因中存在许多突变。 还公开了用于诊断和治疗与该肿瘤抑制因子相关的癌症的方法，称为TS10q23.3。

公开(公告)号：US07354582B2

公开(公告)日：2008-04-08

申请号：US11373462

申请日：2006-03-10

申请人： W. K. Alfred Yung ,  Candelaria Gomez-Manzano ,  Juan Fueyo ,  Jesse M. Cedarbaum ,  Jocelyn Holash

发明人： W. K. Alfred Yung ,  Candelaria Gomez-Manzano ,  Juan Fueyo ,  Jesse M. Cedarbaum ,  Jocelyn Holash

IPC分类号： A61K38/18 ,  C07K14/71 ,  C12N15/62

CPC分类号： A61K38/179 ,  C07K2319/30

摘要： Methods for treating a human patient suffering from a brain tumor, including glioblastoma, by administering an effective amount of a vascular endothelial growth factor (VEGF) inhibitor to the human patient. The VEGF inhibitor is a VEGF antagonist protein comprising a dimeric protein having two fusion polypeptides having the sequence of SEQ ID NO:2.

摘要翻译： 通过向人类患者施用有效量的血管内皮生长因子（VEGF）抑制剂来治疗患有脑肿瘤的人类患者，包括成胶质细胞瘤的方法。 VEGF抑制剂是包含具有两个具有SEQ ID NO：2的序列的融合多肽的二聚体蛋白质的VEGF拮抗剂蛋白质。