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公开(公告)号：US07354582B2
公开(公告)日：2008-04-08
申请号：US11373462
申请日：2006-03-10
申请人： W. K. Alfred Yung , Candelaria Gomez-Manzano , Juan Fueyo , Jesse M. Cedarbaum , Jocelyn Holash
发明人： W. K. Alfred Yung , Candelaria Gomez-Manzano , Juan Fueyo , Jesse M. Cedarbaum , Jocelyn Holash
CPC分类号： A61K38/179 , C07K2319/30
摘要： Methods for treating a human patient suffering from a brain tumor, including glioblastoma, by administering an effective amount of a vascular endothelial growth factor (VEGF) inhibitor to the human patient. The VEGF inhibitor is a VEGF antagonist protein comprising a dimeric protein having two fusion polypeptides having the sequence of SEQ ID NO:2.
摘要翻译： 通过向人类患者施用有效量的血管内皮生长因子（VEGF）抑制剂来治疗患有脑肿瘤的人类患者，包括成胶质细胞瘤的方法。 VEGF抑制剂是包含具有两个具有SEQ ID NO：2的序列的融合多肽的二聚体蛋白质的VEGF拮抗剂蛋白质。
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公开(公告)号：US20070212354A1
公开(公告)日：2007-09-13
申请号：US11373462
申请日：2006-03-10
IPC分类号： A61K39/395 , A61K38/18
CPC分类号： A61K38/179 , C07K2319/30
摘要： Methods for treating a human patient suffering from a brain tumor, including glioblastoma, by administering an effective amount of a vascular endothelial growth factor (VEGF) inhibitor to the human patient. The VEGF inhibitor is a VEGF antagonist protein comprising a dimeric protein having two fusion polypeptides having the sequence of SEQ ID NO:2.
摘要翻译： 通过向人类患者施用有效量的血管内皮生长因子（VEGF）抑制剂来治疗患有脑肿瘤的人类患者，包括成胶质细胞瘤的方法。 VEGF抑制剂是包含具有两个具有SEQ ID NO：2的序列的融合多肽的二聚体蛋白质的VEGF拮抗剂蛋白质。
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3.发明授权Antitumor combinations containing a VEGF-inhibiting agent and 5FU or a derivative thereof 有权含有VEGF抑制剂和5FU或其衍生物的抗肿瘤组合公开(公告)号：US08388963B2
公开(公告)日：2013-03-05
申请号：US12508834
申请日：2009-07-24
申请人： Patricia Vrignaud , Marielle Chiron-Blondel , Marie-Christine Bissery , Eric Furfine , Jocelyn Holash , Jesse M. Cedarbaum
发明人： Patricia Vrignaud , Marielle Chiron-Blondel , Marie-Christine Bissery , Eric Furfine , Jocelyn Holash , Jesse M. Cedarbaum
CPC分类号： A61K31/513 , A61K31/505 , A61K31/519 , A61K31/7068 , A61K38/179 , A61K38/18 , A61K45/00 , A61K2300/00
摘要： This invention relates to antitumor combinations comprising a VEGF inhibitor combined with 5-fluorouracil or with a 5-fluoropyrimidine derivative that are therapeutically useful in the treatment of neoplastic diseases, and pharmaceutical compositions comprising such combinations.
摘要翻译： 本发明涉及包含与5-氟尿嘧啶组合的VEGF抑制剂或可用于治疗肿瘤性疾病的5-氟嘧啶衍生物的抗肿瘤组合物，以及包含这些组合的药物组合物。
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4.发明授权公开(公告)号：US07449182B2
公开(公告)日：2008-11-11
申请号：US12002115
申请日：2007-12-14
申请人： Jesse M. Cedarbaum , Jocelyn Holash
发明人： Jesse M. Cedarbaum , Jocelyn Holash
CPC分类号： C07K14/71 , A61K31/138 , A61K31/355 , A61K31/401 , A61K31/403 , A61K31/553 , A61K38/00 , A61K38/17 , A61K45/06 , C07K2319/30 , A61K2300/00
摘要： Disclosed are compositions and methods for treating a disease or condition related to angiogenesis with a vascular endothelial growth factor (VEGF) inhibitor and one or more anti-hypertensive agent(s). The method of the invention is useful for preventing the development of hypertension and/or reducing hypertension in a subject treated with a VEGF inhibitor.
摘要翻译： 公开了用血管内皮生长因子（VEGF）抑制剂和一种或多种抗高血压药物治疗与血管发生相关的疾病或病症的组合物和方法。 本发明的方法可用于预防用VEGF抑制剂治疗的受试者的高血压和/或降低高血压的发展。
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5.发明授权Methods of treating anemia by inhibition of vascular endothelial growth factor (VEGF) 有权通过抑制血管内皮生长因子（VEGF）治疗贫血的方法公开(公告)号：US07351411B2
公开(公告)日：2008-04-01
申请号：US11373358
申请日：2006-03-10
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/30
摘要： Methods of treating anemic disorders in human subjects comprising administering a VEGF antagonist comprising a fusion polypeptide having an immunoglobulin-like (Ig) domain 2 of the VEGF receptor Flt1 and Ig domain 3 of the VEGF receptor Flk1 or Flt4, and a multimerizing component. Further included are methods of preventing anemia, increasing hematocrit levels, and increasing or stimulating erythropoietin, particularly in subjects being treated for cancer with chemotherapeutic agents and/or radiation.
摘要翻译： 治疗人受试者中贫血障碍的方法包括给予包含融合多肽的VEGF拮抗剂，所述融合多肽具有VEGF受体Flt1的免疫球蛋白样（Ig）结构域2和VEGF受体Flk1或Flt4的Ig结构域3和多聚化成分。 还包括预防贫血，增加血细胞比容水平以及增加或刺激促红细胞生成素的方法，特别是在用化学治疗剂和/或辐射治疗癌症的受试者中。
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公开(公告)号：US07354581B2
公开(公告)日：2008-04-08
申请号：US11350145
申请日：2006-02-08
申请人： Jesse M. Cedarbaum , Jocelyn Holash
发明人： Jesse M. Cedarbaum , Jocelyn Holash
CPC分类号： C07K14/71 , A61K31/138 , A61K31/355 , A61K31/401 , A61K31/403 , A61K31/553 , A61K38/00 , A61K38/17 , A61K45/06 , C07K2319/30 , A61K2300/00
摘要： Disclosed are compositions and methods for treating a disease or condition related to angiogenesis with a vascular endothelial growth factor (VEGF) inhibitor and one or more anti-hypertensive agent(s). The method of the invention is useful for preventing the development of hypertension and/or reducing hypertension in a subject treated with a VEGF inhibitor.
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公开(公告)号：US20080145363A1
公开(公告)日：2008-06-19
申请号：US12002115
申请日：2007-12-14
申请人： Jesse M. Cedarbaum , Jocelyn Holash
发明人： Jesse M. Cedarbaum , Jocelyn Holash
CPC分类号： C07K14/71 , A61K31/138 , A61K31/355 , A61K31/401 , A61K31/403 , A61K31/553 , A61K38/00 , A61K38/17 , A61K45/06 , C07K2319/30 , A61K2300/00
摘要： Disclosed are compositions and methods for treating a disease or condition related to angiogenesis with a vascular endothelial growth factor (VEGF) inhibitor and one or more anti-hypertensive agent(s). The method of the invention is useful for preventing the development of hypertension and/or reducing hypertension in a subject treated with a VEGF inhibitor.
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8.发明授权Method of treating cancer with a VEGF antagonist and an anti-proliferative agent 有权用VEGF拮抗剂和抗增殖剂治疗癌症的方法公开(公告)号：US07354579B2
公开(公告)日：2008-04-08
申请号：US10897802
申请日：2004-07-23
申请人： Jocelyn Holash , Robert Jaffe , Limin Hu , George D. Yancopoulos
发明人： Jocelyn Holash , Robert Jaffe , Limin Hu , George D. Yancopoulos
CPC分类号： A61K45/06 , A61K31/337 , A61K31/555 , A61K33/24 , A61K38/179 , A61K2300/00
摘要： Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth factor (VEGF) antagonist, such as a VEGF trap, an anti-proliferative agent, such as taxol, and a pharmaceutically acceptable carrier.
摘要翻译： 在有需要的受试者中治疗癌症和/或减少或抑制肿瘤生长的方法，包括给予包含血管内皮细胞生长因子（VEGF）拮抗剂如VEGF陷阱，抗增殖剂如紫杉醇的药物组合物 ，和药学上可接受的载体。
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公开(公告)号：US20050032699A1
公开(公告)日：2005-02-10
申请号：US10897802
申请日：2004-07-23
申请人： Jocelyn Holash , Robert Jaffe , Limin Hu , George Yancopoulos
发明人： Jocelyn Holash , Robert Jaffe , Limin Hu , George Yancopoulos
IPC分类号： A61K31/337 , A61K31/555 , A61K33/24 , A61K38/17 , A61K39/395 , A61K45/06 , A61P35/00
CPC分类号： A61K45/06 , A61K31/337 , A61K31/555 , A61K33/24 , A61K38/179 , A61K2300/00
摘要： Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth factor (VEGF) antagonist, such as a VEGF trap, an anti-proliferative agent, such as taxol, and a pharmaceutically acceptable carrier.
摘要翻译： 在有需要的受试者中治疗癌症和/或减少或抑制肿瘤生长的方法，包括给予包含血管内皮细胞生长因子（VEGF）拮抗剂如VEGF陷阱，抗增殖剂如紫杉醇的药物组合物 ，和药学上可接受的载体。
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10.发明申请公开(公告)号：US20060178305A1
公开(公告)日：2006-08-10
申请号：US11293761
申请日：2005-12-02
申请人： Patricia Vrignaud , Marielle Chiron-Blondel , Marie-Christine Bissery , Eric Furfine , Jocelyn Holash , Jesse Cedarbaum
发明人： Patricia Vrignaud , Marielle Chiron-Blondel , Marie-Christine Bissery , Eric Furfine , Jocelyn Holash , Jesse Cedarbaum
IPC分类号： A61K38/17 , A61K31/7072 , A61K31/513 , A61K31/525
CPC分类号： A61K31/513 , A61K31/505 , A61K31/519 , A61K31/7068 , A61K38/179 , A61K38/18 , A61K45/00 , A61K2300/00
摘要： This invention relates to antitumor combinations comprising a VEGF inhibitor combined with 5-fluorouracil or with a 5-fluoropyrimidine derivative that are therapeutically useful in the treatment of neoplastic diseases, and pharmaceutical compositions comprising such combinations.
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