公开(公告)号：US07992314B2

公开(公告)日：2011-08-09

申请号：US12313061

申请日：2008-11-17

申请人： Peter Strack ,  Jens Stockburger ,  Zoran Ostric

发明人： Peter Strack ,  Jens Stockburger ,  Zoran Ostric

IPC分类号： G05B19/42 ,  G01B5/02 ,  G01B5/004

CPC分类号： G05B19/42 ,  G01B5/061 ,  Y02P90/265

摘要： An elevation measuring device comprises a measuring column at which a vertically movable measuring slide is supported, so it can be moved by hand and also by a drive motor through a clutch device. The measuring slide supports a scan head, which imparts a constant measuring force onto the measuring location at the work piece, which is generated by the drive motor and the clutch device. A measuring system detects the elevation coordinate of the scan head and hands said elevation coordinate to a control device for further processing and evaluation. The control device comprises logic for automating the measuring process. This logic automatically detects a positioning of the scan head in a certain direction, which is manually performed by the operator, subsequently controls the drive motor in a suitable manner in order to cause a scanning of the work piece and determines the measurement values.

摘要翻译： 仰角测量装置包括测量柱，支撑可垂直移动的测量滑块，因此可以通过手动以及驱动马达通过离合器装置来移动。 测量滑块支撑扫描头，该扫描头在工件的测量位置上施加恒定的测量力，该测量力由驱动电机和离合器装置产生。 测量系统检测扫描头的仰角坐标，将手的仰角坐标检测到控制装置，以进行进一步的处理和评估。 控制装置包括用于使测量过程自动化的逻辑。 该逻辑自动检测扫描头在由操作者手动执行的特定方向上的定位，随后以合适的方式控制驱动马达，以便对工件进行扫描并确定测量值。

公开(公告)号：US20090071024A1

公开(公告)日：2009-03-19

申请号：US12313061

申请日：2008-11-17

申请人： Peter Strack ,  Jens Stockburger ,  Zoran Ostric

发明人： Peter Strack ,  Jens Stockburger ,  Zoran Ostric

IPC分类号： G01B5/02

CPC分类号： G05B19/42 ,  G01B5/061 ,  Y02P90/265

摘要： An elevation measuring device (1) comprises a measuring column (3) at which a vertically movable measuring slide (4) is supported, so it can be moved by hand and also by a drive motor (14) through a clutch device (15). The measuring slide (4) supports a scan head (8), which imparts a constant measuring force onto the measuring location at the work piece, which is generated by the drive motor (14) and the clutch device (15). A measuring system (19) detects the elevation coordinate of the scan head (8) and hands said elevation coordinate to a control device (21) for further processing and evaluation. The control device (21) comprises logic (33) for automating the measuring process. This logic automatically detects a positioning of the scan head (8) in a certain direction, which is manually performed by the operator, subsequently controls the drive motor (14) in a suitable manner in order to cause a scanning of the work piece and determines the measurement values, which are relevant for the respective measurement, from the signals of the measuring system (19). The control device (21) can be configured to fully automatically detect the intention of the operator to measure either on a plane or in a bore hole or on a shaft, in one direction or in the opposite direction, and to independently initiate the intended measuring function.

摘要翻译： 仰角测量装置（1）包括测量柱（3），在该测量柱（3）上支撑有可垂直移动的测量滑块（4），从而可以通过手动以及驱动马达（14）通过离合器装置（15）移动， 。 测量滑块（4）支撑扫描头（8），该扫描头（8）对由驱动电机（14）和离合器装置（15）产生的工件上的测量位置施加恒定的测量力。 测量系统（19）检测扫描头（8）的仰角坐标，并将所述高程坐标指向控制装置（21），用于进一步的处理和评估。 控制装置（21）包括用于使测量过程自动化的逻辑（33）。 该逻辑自动检测扫描头（8）在由操作者手动执行的特定方向上的定位，随后以合适的方式控制驱动马达（14），以便对工件进行扫描并确定 与测量系统（19）的信号相关的测量值。 控制装置（21）可以被配置为完全自动地检测操作者在一个方向或相反方向上在平面或钻孔中或在轴上测量的意图，并且独立地启动预期的测量 功能。

公开(公告)号：US06700391B2

公开(公告)日：2004-03-02

申请号：US10088641

申请日：2002-03-20

申请人： Peter Strack ,  Christian Steiner

发明人： Peter Strack ,  Christian Steiner

IPC分类号： G01R2726

CPC分类号： G01D5/2412

摘要： A distance measuring system (1) is provided with a capacitive sensor (7a, 7b), designed in the form of a differential capacitor (18), for which the partial capacitors (C1, C2 have capacitances that depend on the position to be determined. The system also includes a processing device (5) for determining the desired distance that contains, for example, a sigma/delta demodulator. The partial capacitors (C1, C2) are triggered periodically with binary signals, wherein the trigger signals from the one partial capacitor (C1) are transmitted with a phase offset to the signals from the other partial capacitor (C2). The processing device (5) determines which trigger signals must be used for the evaluation. Within time windows that are synchronized with the edges of the trigger signals, a switch unit (22) allows the associated receiving signals to pass through to the processing unit (5) and blanks out all other signals. The distance measuring system (1) makes it possible to have a low number of interpolation errors with high resolution and long interpolation periods. The distance measuring system (1) can be expanded by adding two essentially independent, parallel-operating relative measuring systems to form an absolute distance measuring system, which determines the absolute position solely from the current measuring values. A nearly optional enlargement of the measuring range is possible by adding further relative measuring systems.

摘要翻译： 距离测量系统（1）设置有以差分电容器（18）的形式设计的电容式传感器（7a，7b），部分电容器（C1，C2）具有取决于要确定的位置的电容 该系统还包括用于确定包含例如Σ/Δ解调器的期望距离的处理设备（5），部分电容器（C1，C2）用二进制信号周期性触发，其中来自一个 部分电容器（C1）以相位偏移方式传输到来自另一部分电容器（C2）的信号，处理装置（5）确定哪些触发信号必须用于评估，在与 触发信号，开关单元（22）允许相关联的接收信号通过处理单元（5）并消除所有其它信号，距离测量系统（1）使得可以具有低数量的i 具有高分辨率和长内插周期的插值误差。 距离测量系统（1）可以通过添加两个基本上独立的并行操作的相对测量系统来扩展，以形成绝对距离测量系统，其仅从当前测量值确定绝对位置。 通过添加进一步的相对测量系统，可以几乎可选地扩大测量范围。

公开(公告)号：US20110166028A1

公开(公告)日：2011-07-07

申请号：US12674981

申请日：2008-08-22

申请人： Donald Bergstrom ,  Xudong Dai ,  James Hardwick ,  Cole Liberator ,  A. Thomas Look ,  Jennifer O'Neil ,  Sudhir Rao ,  Peter Strack ,  Christopher Winter ,  Theresa Zhang

发明人： Donald Bergstrom ,  Xudong Dai ,  James Hardwick ,  Cole Liberator ,  A. Thomas Look ,  Jennifer O'Neil ,  Sudhir Rao ,  Peter Strack ,  Christopher Winter ,  Theresa Zhang

IPC分类号： C40B30/00 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6886 ,  C12Q2600/106

摘要： The invention relates to the identification and use of gene expression profiles with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. The same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. The methods may further comprise selecting a treatment based on the classifying step.

摘要翻译： 本发明涉及鉴定和使用与细胞增殖性疾病的治疗有关的基因表达谱，特别是使用Notch信号传导抑制剂由异常Notch信号转导介导的基因表达谱。 特别地，本发明提供基因的身份，其个体或累积表达模式可用于各种测定。 基因表达谱，无论是体现在核酸表达，蛋白质表达或其他表达形式中，都可用于选择患有Notch介导的癌症的受试者，其可能对用γ-分泌酶抑制剂或另一种Notch抑制剂治疗有反应。 在用其他Notch抑制剂治疗的患者的分类中可以使用相同的标记。 该方法还可以包括基于分类步骤提供诊断，预测或预测信息。 所述方法可以进一步包括基于分类步骤来选择治疗。

公开(公告)号：US5461320A

公开(公告)日：1995-10-24

申请号：US231259

申请日：1994-04-22

申请人： Peter Strack ,  Andreas Kaiser

发明人： Peter Strack ,  Andreas Kaiser

IPC分类号： G01B7/00 ,  G01D5/241 ,  G01R27/26 ,  G08C19/10

CPC分类号： G01D5/2415

摘要： A capacitive measuring device or apparatus; in particular, a length-measuring apparatus, which incorporates a scale portion and a scanning unit which is movable relative to the former and which supports transmitting electrodes and at least one receiving electrode. Herein, a transmission circuit applies transmitting signals at a basic frequency to the transmitting electrodes, and with the receiving electrode being connected to a reception circuit, to the output side of which there is connected an evaluating circuit for the receiving signals. The transmitting signals are applied to the transmitting electrodes through a pulse width modulator and a synchronous modulator and the receiving signal is conducted through a demodulator. The synchronous modulator and demodulator operate at the same modulation frequency, which is higher than the basic or basic frequency; and when the scanning unit is at a standstill relative to the scale portion, the base frequency of the receiving signal is equal to the base frequency of the transmitting signals, and upon movement of the scanning unit relative to the scale portion the basic frequency of the receiving signals changes in conformance with the speed of movement relative to the basic frequency of the transmitting signals, whereby a change in frequency is evaluated by the evaluating circuit so as to display the length or extent of the movement.

摘要翻译： 电容测量装置或装置; 特别是长度测量装置，其包括刻度部分和扫描单元，扫描单元可相对于前者移动并且支撑发射电极和至少一个接收电极。 这里，发送电路将基本频率的发送信号施加到发送电极，并且接收电极与接收电路连接，其输出侧连接有用于接收信号的评估电路。 发射信号通过脉宽调制器和同步调制器施加到发射电极，接收信号通过解调器传导。 同步调制器和解调器工作在相同的调制频率，高于基本或基本频率; 并且当扫描单元相对于标尺部分处于停止状态时，接收信号的基本频率等于发送信号的基本频率，并且当扫描单元相对于刻度部分移动时，基本频率为 接收信号相对于发送信号的基本频率的移动速度变化，由评估电路评估频率变化，以显示移动的长度或程度。